DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip75B and ppardb

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_571543.1	Gene:	ppardb / 30754	ZFINID:	ZDB-GENE-000112-47	Length:	517	Species:	Danio rerio

Alignment Length:	486	Identity:	146/486 - (30%)
Similarity:	229/486 - (47%)	Gaps:	63/486 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 ASVSSSSSSSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVM---RPPPPPPP 411
            |....|:||...|:.............|..|.:|::...:.....:.|.|.:..   |.|...||
Zfish    45 AQEGESASSDCGGTSDLQEPSSVSGEEVEGSETSDITGLEASPGSKGSWGGNQQNGDRTPQESPP 109

  Fly   412 PKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPD-LEFD-------GTTVLCRVCGDKASGF 468
            |           ||.:..|..:.|... :.||.|:.| |...       |..|.||:||||||||
Zfish   110 P-----------NSETPVTAGAFSDPL-QVPSLSLSDQLRLGREDPNKLGLNVECRICGDKASGF 162

  Fly   469 HYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGR 533
            |||||:||||||||||:|:.|::|..|  .:.|.:.:.:||:|||||.:||:|:|||.||:|:||
Zfish   163 HYGVHACEGCKGFFRRTIRMKLEYERC--ERACKVQKKSRNKCQYCRFQKCLALGMSHDAIRYGR 225

  Fly   534 VPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDC 598
            :|:.||.:::|.:......:....|      |...|...|..|:|.....||:|..::......|
Zfish   226 MPEAEKKKLVAGLLAGENPQSSSGA------DLKTLAKHVNTAYLRNLNMTKKKARSILTGKTSC 284

  Fly   599 PS----YSMPTLLAC-------PLNPAPELQSEQEFSQRFAHV-----------IRGVIDFAGMI 641
            .:    :.|.:|...       .||.||   ..:|..   .||           :|.:.:||..|
Zfish   285 TAPFVIHDMDSLWQAENGLVWNQLNGAP---LNKEIG---VHVFYRCQCTTVETVRELTEFAKNI 343

  Fly   642 PGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARF--LVDS 704
            |||..|..:|:.||||.|:.:|:|..|..:.:.  :.::..||:..............|  :::.
Zfish   344 PGFVDLFLNDQVTLLKYGVHEAIFAMLPSLMNK--DGLLVANGKGFVTREFLRSLRKPFSEIMEP 406

  Fly   705 TFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEF 769
            .|.||.:.|::.|.|:::.||.|.:::..|||||.|::.:|::...:...|...:..:.||....
Zfish   407 KFEFAVKFNALELDDSDLALFVAAIILCGDRPGLMNVKQVEQIQDGILQALDQHLQVHHPDSSHL 471

  Fly   770 LAKLLETMPDLRTLSTLHTEKLVVFRTEHKE 800
            ..|||:.|.|||.|.|.:.:.:.:.:....|
Zfish   472 FPKLLQKMADLRQLVTENAQLVQMIKKTESE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	53/87 (61%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	55/206 (27%)
ppardb	NP_571543.1	NR_DBD_Ppar	151..234	CDD:143523	51/84 (61%)
ppardb	NP_571543.1	NR_LBD_PPAR	250..516	CDD:132730	68/267 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26498
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010