DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip75B and Thrb

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	XP_006251771.1	Gene:	Thrb / 24831	RGDID:	3858	Length:	514	Species:	Rattus norvegicus

Alignment Length:	437	Identity:	126/437 - (28%)
Similarity:	199/437 - (45%)	Gaps:	68/437 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 SSSSNMHHQQQQQQQQSSLGNSVMRPPPPPPPPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSS 444
            |..|::.....|..|.:.|       |...|.|:|:               :...|...|..||.
  Rat   111 SKDSDLDMALSQYSQPAHL-------PEEKPFPQVR---------------SPPHSHKKGYIPSY 153

  Fly   445 SIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKI--QYRPCTKNQQCSILRIN 507
            ...|       .||.||||||:|:||...:||||||||||:||:.:  .| .|....:|.|.::.
  Rat   154 LDKD-------ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSY-SCKYEGKCIIDKVT 210

  Fly   508 RNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATEL--------- 563
            ||:||.||.||||.|||:.|.|       .:.::.||..:...:||.::|  ..||
  Rat   211 RNQCQECRFKKCIYVGMATDLV-------LDDSKRLAKRKLIEENREKRR--REELQKSIGHKPE 266

  Fly   564 --DDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPE-----LQSEQ 621
              |::..|:..|..||:.    |..:.|..:|:.:..|.    .:...|:..|||     |::..
  Rat   267 PTDEEWELIKTVTEAHVA----TNAQGSHWKQKRKFLPE----DIGQAPIVNAPEGGKVDLEAFS 323

  Fly   622 EFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQV 686
            .|::.....|..|:|||..:|.|..|..:|:..|||....:.:.:|....:|.. :..:.|||::
  Rat   324 HFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPD-SETLTLNGEM 387

  Fly   687 -MRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSR 750
             :.|..::|| ....:.|:.|:....::|.||.|.|:.|..|::|::.|||||..:|.|||....
  Rat   388 AVTRGQLKNG-GLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDS 451

  Fly   751 LKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTE 797
            .....::.:...:.....|..|||..:.|||.:...|..:.:..:.|
  Rat   452 FLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	42/89 (47%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	53/192 (28%)
Thrb	XP_006251771.1	NR_DBD_TR	159..245	CDD:143519	44/93 (47%)
Thrb	XP_006251771.1	NR_LBD_TR	269..511	CDD:132733	63/240 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010