DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip75B and Rarb

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_001276689.1	Gene:	Rarb / 218772	MGIID:	97857	Length:	482	Species:	Mus musculus

Alignment Length:	541	Identity:	160/541 - (29%)
Similarity:	239/541 - (44%)	Gaps:	107/541 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 SSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMR-------------PPP----PPPPPK 413
            |:|||....|.|..      |...........|...|:|             |||    .|.|..
Mouse     2 STSSHACPVPAVRG------HMTHYPAAPYPLLFPPVIRGLSLPPLHGLHGHPPPSGCSTPSPAS 60

  Fly   414 VKHASSSSSGNSS---------SSNTNNSSSSSNGEE----PSSSIPDLEFDGTTVLCRVCGDKA 465
            |..|...::|.|.         |.|....:.|::.||    |.|.:|.   ......|.||.||:
Mouse    61 VGQACQRTTGGSQFAASTKWTPSLNAAIETQSTSSEELVPSPPSPLPP---PRVYKPCFVCQDKS 122

  Fly   466 SGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVR 530
            ||:||||.:|||||||||||||:.:.| .|.:::.|.|.::.|||||||||:||..||||:::||
Mouse   123 SGYHYGVSACEGCKGFFRRSIQKNMIY-TCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVR 186

  Fly   531 FGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLET----CEFTKEKV-SA 590
            ..|..|::        :.|.|...:...:..||||   |...:.:||.||    |:..|... |:
Mouse   187 NDRNKKKK--------EPSKQECTESYEMTAELDD---LTEKIRKAHQETFPSLCQLGKYTTNSS 240

  Fly   591 MRQRARDCPSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTL 655
            ...|.|                  .:|....:||:.....|..:::||..:|||..||..|:.||
Mouse   241 ADHRVR------------------LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITL 287

  Fly   656 LKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARF--LVDSTFNFAERMNSMNLT 718
            |||...|.|.:|:...:....:::...:|..:.|..:.   ||.|  |.|..|.||.::..:.:.
Mouse   288 LKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMH---NAGFGPLTDLVFTFANQLLPLEMD 349

  Fly   719 DAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTL 783
            |.|.||..||.||..||..|.....::|:...|...|:..:.:.||.:|....|:|..:.|||::
Mouse   350 DTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSI 414

  Fly   784 STLHTEKLVVFRTE----HKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVS 844
            |....|:::..:.|    ...|:::.:      .||:|.:..:||.|              |:::
Mouse   415 SAKGAERVITLKMEIPGSMPPLIQEML------ENSEGHEPLTPSSS--------------GNIA 459

  Fly   845 STESADLDYGSPSSSQPQGVS 865
            ....:    .||||.:..|||
Mouse   460 EHSPS----VSPSSVENSGVS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	47/87 (54%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	54/188 (29%)
Rarb	NP_001276689.1	Modulating	1..114		27/120 (23%)
		NR_DBD_RAR	109..193	CDD:143522	46/84 (55%)
		Hinge	181..209		7/35 (20%)
		NR_LBD_RAR	213..443	CDD:132735	67/259 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..482		14/52 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010