DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eip75B and Nr1d1

DIOPT Version :9

Sequence 1:NP_001246821.1 Gene:Eip75B / 39999 FlyBaseID:FBgn0000568 Length:1412 Species:Drosophila melanogaster
Sequence 2:NP_663409.2 Gene:Nr1d1 / 217166 MGIID:2444210 Length:615 Species:Mus musculus


Alignment Length:611 Identity:203/611 - (33%)
Similarity:277/611 - (45%) Gaps:188/611 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   361 IGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPP-------------PPPP 412
            |||.|||.|.  .:|....|.|||...|...|      |.....||.|             ..||
Mouse    17 IGSSGSSPSR--TSPESLYSDSSNGSFQSLTQ------GCPTYFPPSPTGSLTQDPARSFGSAPP 73

  Fly   413 KVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLE----------------FDGTTVLCRVC 461
            .:...||.||.:||||  ::|||..||..|.|....:|                .:|..:||:||
Mouse    74 SLSDDSSPSSASSSSS--SSSSSFYNGSPPGSLQVAMEDSSRVSPSKGTSNITKLNGMVLLCKVC 136

  Fly   462 GDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSR 526
            ||.|||||||||:||||||||||||||.|||:.|.||:.|||:||||||||.||.|||::|||||
Mouse   137 GDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSR 201

  Fly   527 DAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPR----------------------- 568
            |||||||:|||||.|:||.||.:......|.:....|:..|.                       
Mouse   202 DAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSLCPLETSPTPHPTSGSMGPSPPPAPAPTPLVG 266

  Fly   569 ----------------------LLAAVLRAHLETCEFTKEKVSAM-------------------R 592
                                  :::.|.|||.|...:..:|:...                   |
Mouse   267 FSQFPQQLTPPRSPSPEPTMEDVISQVARAHREIFTYAHDKLGTSPGNFNANHASGSPSATTPHR 331

  Fly   593 QRARDCPS-------------------------------------------------------YS 602
            ..::.|||                                                       ||
Mouse   332 WESQGCPSAPNDNNLLAAQRHNEALNGLRQGPSSYPPTWPSGPTHHSCHQPNSNGHRLCPTHVYS 396

  Fly   603 MP----------------TLLACPLNPAPELQSE-------QEFSQRFAHVIRGVIDFAGMIPGF 644
            .|                .|||||:|..|..:|.       ::||..|...:|.|::||..||||
Mouse   397 APEGEAPANSLRQGNTKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGF 461

  Fly   645 QLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNG---QVMRRDAIQNGANARFLVDSTF 706
            :.|:|.|:.||||||.|:.|.||...:|:....:::.|:.   .:....|:..|.    |:::.|
Mouse   462 RDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGD----LLNAMF 522

  Fly   707 NFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLA 771
            :|:|::||:.||:.|:|||.|:||::.||.|:.|...:|::...|...|:.:|.:|||.:.....
Mouse   523 DFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPSETSRFT 587

  Fly   772 KLLETMPDLRTLSTLHTEKLVVFRTE 797
            |||..:||||||:.:|:|||:.||.:
Mouse   588 KLLLKLPDLRTLNNMHSEKLLSFRVD 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eip75BNP_001246821.1 NR_DBD_REV_ERB 453..541 CDD:143540 69/87 (79%)
NR_LBD_REV_ERB 609..796 CDD:132738 73/196 (37%)
Nr1d1NP_663409.2 Modulating 1..129 36/121 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..120 36/112 (32%)
Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269|PubMed:30792350 1..70 18/60 (30%)
Crucial for activation of GJA1 49..285 98/237 (41%)
NR_DBD_REV_ERB 128..216 CDD:143540 69/87 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..286 2/50 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..337 1/24 (4%)
NR_LBD 419..612 CDD:299703 73/196 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 132 1.000 Domainoid score I5084
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002268
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24082
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1497
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
55.060

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