Protein Alignment Eip75B and Rxrb

DIOPT Version :10

• Sequence 1: NP_730321.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_001192143.1
• Gene: Rxrb / 20182
• MGIID: 98215
• Length: 524
• Species: Mus musculus
• Alignment Length: 643
• Identity: 159/643 - (24%)
• Similarity: 233/643 - (36%)
• Gaps: 189/643 - (29%)

  Fly   191 PPLHHQQQ------QQQQHVRVIRDGR-----LYDEATVVVAARRHSVSPPPLHHHSRSAPVSPV 244
            ||.|...|      :::.|..|....|     |...|....|..:.::.|.|           ..
Mouse    11 PPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAGEQQALEPEP-----------GE 64

  Fly   245 IARRGGAAAYMDQQYQQRQTP--------PLAPPPPP----PPPPPPPPPPQQQQQQYIST---- 293
            ..|.|...:..|.:.....:|        |.:||.||    .||||.||||.......||:
Mouse    65 AGRDGMGDSGRDSRSPDSSSPNPLSQGIRPSSPPGPPLTPSAPPPPMPPPPLGSPFPVISSSMGS 129

  Fly   294 -GVPPPTAAARKFVVSTSTRHVNVIASNHFQQQQQQHQAQQHQQQHQQHQQHQQHVIASVSSSSS 357
             |:|||  |...|....|:..:|                                         |
Mouse   130 PGLPPP--APPGFSGPVSSPQIN-----------------------------------------S 151

  Fly   358 SSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPPPPPPKVKHASSSSS 422
            :.::..|||......:.||                     ||...:..||||..|        .:
Mouse   152 TVSLPGGGSGPPEDVKPPV---------------------LGVRGLHCPPPPGGP--------GA 187

  Fly   423 GNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQ 487
            |..                               ||.:|||::||.||||:|||||||||:|:|:
Mouse   188 GKR-------------------------------LCAICGDRSSGKHYGVYSCEGCKGFFKRTIR 221

  Fly   488 QKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQN 552
            :.:.| .|..|:.|::.:..||||||||.:||:|.||.|:||:..|             |:....
Mouse   222 KDLTY-SCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEER-------------QRGKDK 272

  Fly   553 RGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPEL 617
            .|.........::.|  :..:|.|.|...:.:.:.|...........|.:.|....|      :.
Mouse   273 DGDGDGAGGAPEEMP--VDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNIC------QA 329

  Fly   618 QSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFV----RLICMFDSSINS 678
            ..:|.|:         ::::|..||.|..|..||:..||:||..:.|..    |.|.:.|    .
Mouse   330 ADKQLFT---------LVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRD----G 381

  Fly   679 IICLNG-QVMRRDAIQNGANARFLVDSTFN-----FAERMNSMNLTDAEIGLFCAIVLITPDRPG 737
            |:...| .|.|..|...|..|.|  |.:.:     ...:|..|.:...|:|...||:|..||..|
Mouse   382 ILLATGLHVHRNSAHSAGVGAIF--DRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKG 444

  Fly   738 LRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFR 795
            |.|...:|.:..::...|:....|..|:|....||||..:|.||::.....|.|..|:
Mouse   445 LSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFK 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_730321.1	NR_DBD_REV_ERB	453..541	CDD:143540	43/87 (49%)
		NR_LBD_REV_ERB	609..796	CDD:132738	54/197 (27%)
Rxrb	NP_001192143.1	Modulating. /evidence=ECO:0000250	1..191		53/293 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..167		43/209 (21%)
		NR_DBD_RXR	191..266	CDD:143514	42/75 (56%)
		Hinge	258..382		31/157 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..285		3/34 (9%)
		NR_LBD_RXR_like	285..502	CDD:132741	60/239 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..323		2/22 (9%)