Protein Alignment Eip75B and Rara

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_001170773.1
• Gene: Rara / 19401
• MGIID: 97856
• Length: 462
• Species: Mus musculus
• Alignment Length: 541
• Identity: 154/541 - (28%)
• Similarity: 238/541 - (43%)
• Gaps: 110/541 - (20%)

  Fly   352 VSSSSSSSAIGSGGSSSSH------IFRTPVVSSSSS----SNMHHQ-----------QQQQQQQ 395
            ::|:|||.....||..:.:      .|..|::...|.    :::.||           ...:.|.
Mouse     1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTSLQHQLPVSGYSTPSPATIETQS 65

  Fly   396 SSLGNSVMRPPPPPPPPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRV 460
            ||....|..||.|||.|::                         .:|               |.|
Mouse    66 SSSEEIVPSPPSPPPLPRI-------------------------YKP---------------CFV 90

  Fly   461 CGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMS 525
            |.||:||:||||.:|||||||||||||:.:.| .|.:::.|.|.::.|||||||||:||..||||
Mouse    91 CQDKSSGYHYGVSACEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFDVGMS 154

  Fly   526 RDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLET----CEFTKE 586
            :::||..|..|:::|......:..|        |..|:.:   |:..|.:||.||    |:..|.
Mouse   155 KESVRNDRNKKKKEAPKPECSESYT--------LTPEVGE---LIEKVRKAHQETFPALCQLGKY 208

  Fly   587 KV-SAMRQRARDCPSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQD 650
            .. ::..||.                  :.::....:||:.....|...::||..:|||..||..
Mouse   209 TTNNSSEQRV------------------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIA 255

  Fly   651 DKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARF--LVDSTFNFAERMN 713
            |:.|||||...|.|.:|:...:....:::...:|..:.|..:.   ||.|  |.|..|.||.::.
Mouse   256 DQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMH---NAGFGPLTDLVFAFANQLL 317

  Fly   714 SMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMP 778
            .:.:.|||.||..||.||..||..|...:.::.:...|...|:..|.:.||.:|....|:|..:.
Mouse   318 PLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382

  Fly   779 DLRTLSTLHTEKLVVFRTE---HKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPL 840
            |||::|....|:::..:.|   ....|.|:|  :|:....|....:|..|:    .|......|.
Mouse   383 DLRSISAKGAERVITLKMEIPGSMPPLIQEM--LENSEGLDTLSGQSGGGT----RDGGGLAPPP 441

  Fly   841 GSVSSTESADLDYGSPSSSQP 861
            ||.|.:.|......||::..|
Mouse   442 GSCSPSLSPSSHRSSPATQSP 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	47/87 (54%)
		NR_LBD_REV_ERB	609..796	CDD:132738	54/188 (29%)
Rara	NP_001170773.1	Modulating	1..87		21/110 (19%)
		DUF3454	19..>68	CDD:371809	7/48 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..77		5/24 (21%)
		NR_DBD_RAR	82..166	CDD:143522	48/124 (39%)
		Hinge	154..182		8/35 (23%)
		NR_LBD_RAR	186..416	CDD:132735	68/255 (27%)
		Required for binding corepressor NCOR1	404..419		4/16 (25%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P10276	408..416		3/9 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..462		11/45 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010