Protein Alignment Eip75B and nhr-85

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_001021667.1
• Gene: nhr-85 / 191732
• WormBaseID: WBGene00003675
• Length: 514
• Species: Caenorhabditis elegans
• Alignment Length: 570
• Identity: 177/570 - (31%)
• Similarity: 247/570 - (43%)
• Gaps: 151/570 - (26%)

  Fly   361 IGSGGSSSSHI-------FRTPVVSSSSSSNMHHQQQQQQQQSSL----GNSVMRPPPPP----P 410
            :.:.||...|:       .:||.:.:|.||      ......|||    .:|..||..|.    |
 Worm     3 LSTSGSLPCHLPLSLLTNLQTPPIDTSFSS------PPATSSSSLLSPSPSSAFRPVVPKSLMNP 61

  Fly   411 PPKVKHASSSSSGNSSSSNTNNSSSSSNGE-EPSSSIPDLEFDGT---TVLCRVCGDKASGFHYG 471
            .|.:.....|:..:...|.||:...|.:|. |.|.|:...|...|   |:||:||.|||||||||
 Worm    62 QPAMDTFYMSAIQSLVVSTTNDDQYSEHGALEGSKSLAKDENASTSAGTILCQVCSDKASGFHYG 126

  Fly   472 VHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPK 536
            |.:||||||||||||||||.||.||:.:.|.|||.||||||.||||||:||||||||||||||||
 Worm   127 VFACEGCKGFFRRSIQQKITYRACTRAEDCLILRNNRNRCQCCRLKKCLAVGMSRDAVRFGRVPK 191

  Fly   537 REKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSY 601
            |||||:...||: |..:.|:..:|.:.::...::..:.:| ..|.:.|.||.:.        |.|
 Worm   192 REKARMFEEMQK-TNVQSQRDQIAIQYENLTEVMHKINQA-FGTLQATLEKCTG--------PIY 246

  Fly   602 SMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFV 666
            :.    .||:.           |......::..||||..||.|..:||..:..||:..:||.:.:
 Worm   247 TD----RCPIT-----------SNFIVIPLKAAIDFANSIPAFLSITQTQRVHLLQNSVFDVMLL 296

  Fly   667 RL-------------ICMFDSSINSIICLNGQVMRRDAIQN-GANARFLVDSTFNFAERMNSMNL 717
            ..             :....||.|.||        ..|||: .|..|.|...|
 Worm   297 ASASASTSQHFPPGGLTYDQSSANPII--------PQAIQSISARIRQLPPQT------------ 341

  Fly   718 TDAEIGLFCAIVLITPD------RPGLRNLELIEKMY---SRLKGCLQYIVAQNRPDQPEFLAKL 773
                :.:..||.:...|      :|.|    |.|:::   .:|.|      .|:....|..||
 Worm   342 ----VPILTAIAVCQADLLPESQQPML----LAERLWCVLGKLGG------IQSLATAPSLLA-- 390

  Fly   774 LETMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQNK--SPSGSWADAMDVEAA 836
                 |:|||...|:::|            :||..:    :....||.  :|..:.|..:...|.
 Worm   391 -----DVRTLRQWHSDRL------------RQMSQI----SQHFSQNLLIAPVAAAAPVLLPPAF 434

  Fly   837 KSPLGSVSSTESADLD-------------------YGSPSSSQPQGVSLP 867
            .||..|.:||.|:.:.                   ..|..:.:|..:|||
 Worm   435 LSPPASATSTSSSSVKSEFIERHPSIASLLERPRRISSSGAQEPLNLSLP 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	71/90 (79%)
		NR_LBD_REV_ERB	609..796	CDD:132738	47/209 (22%)
nhr-85	NP_001021667.1	NR_DBD_REV_ERB	110..196	CDD:143540	70/85 (82%)
		HOLI	261..>369	CDD:214658	32/135 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I3371
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002268
OrthoInspector	1	1.000	-	-		oto18184
orthoMCL	1	0.900	-	-		OOG6_110445
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4550
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.940