Protein Alignment Eip75B and Ppara

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_001106889.1
• Gene: Ppara / 19013
• MGIID: 104740
• Length: 468
• Species: Mus musculus
• Alignment Length: 491
• Identity: 151/491 - (30%)
• Similarity: 234/491 - (47%)
• Gaps: 93/491 - (18%)

  Fly   336 QQHQQHQQHQQHVIASVSSSSSSS-------AIGS-GGSSSSHIFRTPVVSSSSSSNMHHQQQQQ 392
            ::..|...:.|.:..|:...||.|       .:|| .||..|.|  |..:|.:||.
Mouse    25 EEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVI--TDTLSPASSP--------- 78

  Fly   393 QQQSSLGNSVMRPPPPPPPPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVL 457
                   :||..|..|                           :|..|.|.|::        .:.
Mouse    79 -------SSVSCPVIP---------------------------ASTDESPGSAL--------NIE 101

  Fly   458 CRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAV 522
            ||:|||||||:|||||:||||||||||:|:.|:.|..|  ::.|.|.:.|||:|||||..||::|
Mouse   102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFHKCLSV 164

  Fly   523 GMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEK 587
            |||.:|:||||:|:.|||::.|.:.....:...     :|..|...|...:..|:|:  .|...|
Mouse   165 GMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKD-----SETADLKSLGKRIHEAYLK--NFNMNK 222

  Fly   588 VSA---MRQRARDCPSY---SMPTLLACPLNPAPELQS----EQEFSQRFAH--------VIRGV 634
            |.|   :..:..:.|.:   .|.||.........::.:    ::|...||.|        .:..:
Mouse   223 VKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTEL 287

  Fly   635 IDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANAR 699
            .:||..||||..|..:|:.||||.|:::|:|..|..:.:.. ..:|......:.|:.::| ....
Mouse   288 TEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKD-GMLIAYGNGFITREFLKN-LRKP 350

  Fly   700 F--LVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQN 762
            |  :::..|:||.:.|::.|.|::|.||.|.::...|||||.|:..|||:...:...|:..:..|
Mouse   351 FCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSN 415

  Fly   763 RPDQPEFLAKLLETMPDLRTLSTLHTEKL-VVFRTE 797
            .||......|||:.|.|||.|.|.|.:.: |:.:||
Mouse   416 HPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTE 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	52/87 (60%)
		NR_LBD_REV_ERB	609..796	CDD:132738	58/201 (29%)
Ppara	NP_001106889.1	NR_DBD_Ppar	101..184	CDD:143523	53/84 (63%)
		NR_LBD_PPAR	201..467	CDD:132730	72/255 (28%)
		Required for heterodimerization with RXRA. /evidence=ECO:0000250	304..433		40/130 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42959
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4550
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040