Protein Alignment Eip75B and nhr-173

DIOPT Version :10

• Sequence 1: NP_730321.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_509119.4
• Gene: nhr-173 / 183862
• WormBaseID: WBGene00016975
• Length: 508
• Species: Caenorhabditis elegans
• Alignment Length: 509
• Identity: 109/509 - (21%)
• Similarity: 194/509 - (38%)
• Gaps: 108/509 - (21%)

  Fly   329 HQAQQHQQQHQQHQQHQQHVIASVSSSSSSSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQ 393
            |.:.....|...:.|:|.|...|.|:|||.      ||....|....|.::|...:.
 Worm     5 HYSPTQTDQLFNNFQYQNHTSPSNSTSSSE------GSDQQQIVSDFVDTASFMISW-------- 55

  Fly   394 QQSSLGNSVMRPPPPPPPPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLC 458
              :.||..      |.....:||....         |.|.|.:...::...:...|..:....:|
 Worm    56 --NGLGEF------PDTEEDIKHVIQP---------TENLSLNIEEQKEIVAFHHLPRNVCPTIC 103

  Fly   459 RVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQC-SIL-RINRNRCQYCRLKKCIA 521
            .||||:|:|:||.|.||.|||.||||::..:.:|. |.:..:| ::| :..|..|:.||.:||:.
 Worm   104 AVCGDRATGYHYEVPSCNGCKTFFRRTVLSQRKYE-CMRGGKCFNVLPKEKRCSCRSCRFQKCVE 167

  Fly   522 VGM------SRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLET 580
            |||      :.|::....|    ..:|:...:.|..|.....:..|.|.:...:..|:.|. ::.
 Worm   168 VGMNPFAIQTNDSLSSNAV----VTKIVGKRKNSVDNSIPSTSKLTVLPEVISMDNAIDRL-IDG 227

  Fly   581 CEFTKEKVSAMRQRARDCPSYSMPTL-----------LACPLNPAP-----ELQSEQ-------- 621
            ..:.:.||...|..|.:.|::...:|           :|..|.|.|     ::..|:
 Worm   228 LMYLEIKVDDFRSCAYNPPTHEYRSLKYHLEQQPMISMADKLGPMPNWPLRQISHEEMKEYIESG 292

  Fly   622 -------EFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFV-RLICMFDSSINS 678
                   |....|.:.|...:::|........:.::|:..||:|.:...:.: :....:::..:.
 Worm   293 NSEPMTPERKNWFVYDILTSVEYAKTFMFLHQIGKEDQILLLRAVVLKLMHLNQAFYSYENKYDM 357

  Fly   679 IICLNGQV----MRRDAIQNGANARFLVDSTFNFAERMNSM--------------NLTDAEIGLF 725
            |...:|.|    .:::...|.:.::.:.      .::|..|              .|...|..||
 Worm   358 IFHPDGTVPPHSWKKNENPNDSISQMMT------KQKMEEMKEEFTLSIRQFVTYQLDKREYVLF 416

  Fly   726 CAIVLITPDRPGL----RNLELIEK-MYSRLKGCLQYIVAQNRPDQPEFLAKLL 774
            .||.|......||    |.:...|| .||  |..::|.:|......|...|.::
 Worm   417 KAITLCNATISGLSDHAREVVTREKEKYS--KALMKYCLANRGMKGPAHYAAII 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_730321.1	NR_DBD_REV_ERB	453..541	CDD:143540	34/95 (36%)
		NR_LBD_REV_ERB	609..796	CDD:132738	37/210 (18%)
nhr-173	NP_509119.4	NR_DBD_HNF4A	103..180	CDD:143518	32/77 (42%)
		HOLI	307..476	CDD:214658	31/170 (18%)