Protein Alignment Eip75B and Eip75B

DIOPT Version :10

• Sequence 1: NP_730321.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: XP_061517599.1
• Gene: Eip75B / 1280470
• VectorBaseID: AGAMI1_012295
• Length: 1448
• Species: Anopheles gambiae
• Alignment Length: 1642
• Identity: 755/1642 - (45%)
• Similarity: 904/1642 - (55%)
• Gaps: 445/1642 - (27%)

  Fly    14 GGSSGSVPGSGSGSASK---LIKTEPIDFEMLHLEENERQQDIEREPSSSNSNSNSNSLTPQRYT 75
            ||.||....:.:|||.:   |||||    :...|...||.:.:||.   |....|....:.|
Mosquito     9 GGPSGGAAAAAAGSAVERKILIKTE----DSRGLAHGERGEQVERR---SREEGNEGCRSGQ--- 63

  Fly    76 HVQVQTVPPRQPTGLTTPGGTQKVILTPRVEYVQQRATSSTGGGMKHVYSQQQGTAASRSAPPET 140
                |..|..:....|.|                :..|...|.....||..:.|..:.    |..
Mosquito    64 ----QEAPDDKKAAGTAP----------------EVRTFVLGENQCIVYGARPGDGSR----PAA 104

  Fly   141 TALLTTTSGTPQIIITRTLPSNQHLS-----RRHSASPSALHHYQQQQPQRQQSPPPLHHQQQQQ 200
            ::..:::|.|.|.:....||..:.|.     |....||||        ..||.|||||
Mosquito   105 SSPSSSSSATLQHLPISHLPPKKTLKLALGLRGGPLSPSA--------SSRQPSPPPL------- 154

  Fly   201 QQHVRVIRDGRLYDE-----ATVVVAARRHSVSPPPLHHHSRSAPVSPVIARRGGAAAYMDQQYQ 260
                 .:|  |..||     |.:.:.:|.|.                       |.....|.|.|
Mosquito   155 -----TLR--RTSDEPDRMLARIQIVSRAHP-----------------------GDEGEEDDQQQ 189

  Fly   261 QRQTPPLAPPPPPPPPPPPPPPPQQQQQQYISTGVPPPTAAARKFVVSTSTRHVNVIASNHFQQQ 325
            .:|.|.                                       ||.|..:.|:||....|.|.
Mosquito   190 HQQQPG---------------------------------------VVVTGGQGVHVIRDGRFYQP 215

  Fly   326 QQQHQAQQ-----------HQQQH-----QQHQQHQQHVIASVSSSS--------SSSAIGSGGS 366
            |||.:.::           |.|.|     ||.|||...::|:...||        |.:..|.||:
Mosquito   216 QQQQRHEEAMVEEEPEDAPHGQYHVPLQQQQQQQHSSIIVANGGRSSPLSHQGRLSPAGSGCGGA 280

  Fly   367 SSSH---------------------IFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPPPP 410
            :..|                     |::.|..::|:::......:||||...:  :.|:||||||
Mosquito   281 AVQHPHTSSSITTTTTILVSNERASIYKPPTQATSTTTTTVSSSKQQQQHGHV--TSMQPPPPPP 343

  Fly   411 PPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSC 475
            |.|:....|..||...             ||||||:|||||||||||||||||||||||||||||
Mosquito   344 PLKMSKGGSGGSGGGH-------------EEPSSSMPDLEFDGTTVLCRVCGDKASGFHYGVHSC 395

  Fly   476 EGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKA 540
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   396 EGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKA 460

  Fly   541 RILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPT 605
            ||||||||||||||.|||||:||||||||||:||:||:||||||:|||:||||||||||||||||
Mosquito   461 RILAAMQQSTQNRGNQRALASELDDQPRLLASVLQAHIETCEFTREKVAAMRQRARDCPSYSMPT 525

  Fly   606 LLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLIC 670
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   526 -LACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLIC 589

  Fly   671 MFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDR 735
            |||:||||||||||||||||.||||||||||||||||||||||||.|||||||||||||||||||
Mosquito   590 MFDTSINSIICLNGQVMRRDTIQNGANARFLVDSTFNFAERMNSMQLTDAEIGLFCAIVLITPDR 654

  Fly   736 PGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTEHKE 800
            |||||:||||:||::||.|||.:::|||||:|||:.:||.|||||||||||||||||||||||||
Mosquito   655 PGLRNVELIERMYTKLKACLQSVISQNRPDKPEFMQELLRTMPDLRTLSTLHTEKLVVFRTEHKE 719

  Fly   801 LLRQQMWSMEDGNNS--DGQQNKSPSGSWA---DAMDVEAAKSPLGSVSSTESADLDYGSPSSS- 859
            ||||||||.|:...:  |.   |||: ||:   :.::||.||||:.|||||||.:....|.|||
Mosquito   720 LLRQQMWSAEEDQGAVLDA---KSPA-SWSCDGNQVEVEIAKSPMSSVSSTESTETSSSSSSSSS 780

  Fly   860 --------------QPQGVSLPSPPQQQPSALASSAPLLAATLSGGCP-LRNRANSGSSGDSGAA 909
                          |..|:|         ||.:::||||||||||.|| :|:||:||||     |
Mosquito   781 SLSSEYHHLHHHHHQHGGIS---------SAASAAAPLLAATLSGACPIIRHRASSGSS-----A 831

  Fly   910 EMDIVGSHA-HLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGHAMCQQQQQHPQLHHH 973
            |.|::|..| ||.||||||||::|..............:::.|......|.      .|...|||
Mosquito   832 EDDLIGGTAQHLAQNGLTITPVIRSVGSSSSSSASSASSSSASSGAGASHL------HHHHHHHH 890

  Fly   974 LTAGAARYRKLDSPTDSGIESGNEKNE--------------------------CKAVSSGGSSSC 1012
            :    :|||||||||||||||||||::                          ..:||| |||||
Mosquito   891 V----SRYRKLDSPTDSGIESGNEKHDNPSPQQQQQQLHHQQHHHLLLHPKPASSSVSS-GSSSC 950

  Fly  1013 SSPRSSVDD-ALDCSDAAANHNQVVQHPQLSVVSVSPVRSPQPSTSSHLKRQIVEDMPVLKRVLQ 1076
            ||||||::| ||:.|.:::|                   ...||.:.|..   |::|||||||||
Mosquito   951 SSPRSSLEDPALEDSSSSSN-------------------GKAPSLARHAS---VDNMPVLKRVLQ 993

  Fly  1077 APPLYDTNSLMDEAYKPHKKFRALRHREFETAEADASSSTSGSNSLSAGSP-------RQSPVPN 1134
            |||||||||||||||||||||||:||||.| ||| |||||:.:::.:|.||       ..||.|.
Mosquito   994 APPLYDTNSLMDEAYKPHKKFRAMRHRESE-AEA-ASSSTTTTSASAAPSPSATVLASSSSPRPA 1056

  Fly  1135 SVATPPPSAASAAAGNPA-----------QSQLHMHLT---------------------RSSPK- 1166
            ||..|..|..:.||.:|.           |||||||||                     ||||:
Mosquito  1057 SVPQPQQSVVAIAAPSPPQQPAQQPPQHHQSQLHMHLTRPQTTQSHQSSATGFLQSTSARSSPQP 1121

  Fly  1167 ------------ASMASSHSVLAKSLMAEPRMTPEQMKRSDIIQNYLKRENS------------- 1206
                        :|::|:|||||||||.|||||||||||:|||.||:.||::
Mosquito  1122 PQQQQQHHHHAYSSLSSTHSVLAKSLMEEPRMTPEQMKRTDIIHNYIMRESAQEQQQNYIKQQQQ 1186

  Fly  1207 ---------TAASSTTNGVGNR----------------SPSSSSTPPPSAVQN------------ 1234
                     ...:|..|||..|                |.||.|:|..:|..|
Mosquito  1187 QQQQQGGLLVCGASAANGVFQRASPHLTVSAVSPAPSSSSSSGSSPAAAAAPNGGCPFGGSSSSA 1251

  Fly  1235 -QQRWG------SSSVITTTCQQRQQ------SVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSS 1286
             ..||.      ::||||||...|.|      |::|....|||||||.|..||..|:.|.:.|||
Mosquito  1252 SAGRWQQVIPAVTASVITTTGGHRAQQTPSPGSLTPPDTSSSSSSSSLSVVSSPPSAASPSSSSS 1316

  Fly  1287 SASSCQYFQSPHSTSNGTSAPASSSSGSNSATP------LLELQVDIADSA-----------QPL 1334
            ||:|.:||||||||....:.|||.||....|.|      |:||:|||..||           |||
Mosquito  1317 SATSIRYFQSPHSTMTSPAPPASPSSVVVVAPPHTPSPRLIELKVDIGSSATATTSLDPCHQQPL 1381

  Fly  1335 NLSKKSPTPPPSKL----HALVAAANAVQRYPTLSADVTVTASNGGPPSAAASPAPSSSPPASVG 1395
            |||||||:|.|:.:    .::|...:|:.  |..:|...|.|::....:||.|.:.|::|
Mosquito  1382 NLSKKSPSPAPTPVSVVQRSIVGGPSALS--PVGAATTVVVATSSSSSNAATSSSSSNNP----- 1439

  Fly  1396 SPNPGLSAAVHKVMLEA 1412
                    .:||::|||
Mosquito  1440 --------TIHKILLEA 1448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_730321.1	NR_DBD_REV_ERB	453..541	CDD:143540	87/87 (100%)
		NR_LBD_REV_ERB	609..796	CDD:132738	169/186 (91%)
Eip75B	XP_061517599.1	None