DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5290 and AT5G17270

DIOPT Version :9

Sequence 1:	NP_649026.1	Gene:	CG5290 / 39998	FlyBaseID:	FBgn0036772	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_197229.1	Gene:	AT5G17270 / 831592	AraportID:	AT5G17270	Length:	899	Species:	Arabidopsis thaliana

Alignment Length:	855	Identity:	200/855 - (23%)
Similarity:	364/855 - (42%)	Gaps:	152/855 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TIDELR----EILQRWQEHVKPDPNDNPTSQLKDFLLLIFA------FVQNSFTGPFD------- 87
            |:|...    |:|.:.:..|..|.:|......:..|::..|      |.:.:.||..:
plant    84 TVDSAEQVYSELLDKVESFVVNDSSDEIDKARRAVLVMCLAIATALWFTRCNLTGSTEGSTKCSL 148

  Fly    88 --KLEEYQQIHSELELEKLDALEKLKASGEELNPNVKSVELLLIAREILEGLLE--------NHP 142
              ::.|.:::   :|.|....:: |.:.|.:|.....:::.|:.||.:|..|.:        ...
plant   149 PLRVSESKEL---VEWENWAKIQ-LMSVGSDLLGKFSNLQHLVFARLLLFKLKDLLFEITSTETF 209

  Fly   143 ESKVLIWWRLRLICLHQHVLDDLAASLYEQFKSAAGHLQAHFNQFESRELQSLLLLELANGY--- 204
            |.:.:.||.:|::.:||.||.:.::||:|..:........||.:           ||....|
plant   210 EVRSISWWLVRVLLIHQRVLQERSSSLFEMLQVYMAEAIDHFGE-----------LEKVKSYWGA 263

  Fly   205 --LQFHRSEIASQILDELC-----------KHLQ---------VELKVEGLLGVRTKFQQKALPQ 247
              |:...|.|.|.|..|.|           ..||         :|..|.|.||.||..|.....|
plant   264 NLLEDEASSITSTIHLEACVLQYIYGRIDPSRLQLESAKAAASLEFSVTGALGFRTIHQVDPKAQ 328

  Fly   248 LCL---------KVEHLNEQQPLPP----AVQTNETTKLPKLLLLEDDTRLERIRFVELKDNEVM 299
            :.|         .|...:|:..:.|    ..:..|....|||:..|.:..         ||:  :
plant   329 MVLVANTSSSNGDVRLASEKADVGPYEAWGGEAPEVYMTPKLVNNESEAG---------KDS--V 382

  Fly   300 TLPSVLQALVLAKVKQLKRSTPKDRLADEQLEPYTQTLLYQEHGPFQVRQSALLLNCLQESNQRR 364
            .|..|.|||:||:...::|.:..|.:....:.||.:.:..|:...|.:|....||....||.:.|
plant   383 PLKPVEQALILAQCLLIERGSRHDEMQRWDMAPYIEAIDSQKSTYFVLRCFCDLLRVRWESTRGR 447

  Fly   365 TVERSWKQCEECVKLLDTSEEELSLRSRLSYGFAAHLSPKWQVQLQLVDLLRSLGMTKTALDICL 429
            |..|:.:..::.|..::.|:..:|.|..|.|  |.||.....::.:..:||.|.|:...|:.|..
plant   448 TKGRALEMMDKLVGAINKSDPGVSNRIPLCY--AVHLPTIPALRKEYGELLVSCGLVGEAITIFE 510

  Fly   430 RIHAWQQVIECYTSLELRHKAAEIIRQELEKKPT-ALLYCLLGDAIDDPSFYEQAWLYSKKTSGK 493
            .:..|..:|.||..|..:..|.::|...|.::|. ..|:|.|||...:.|.||:|...|...|.:
plant   511 SLELWDNLIYCYCLLGKKSAAVDLINARLLERPNDPRLWCSLGDVTINDSCYEKALEVSNDKSVR 575

  Fly   494 AQAYWGNHFYRSADYAQAMDHFEISLEINNLQEAILLRCGYCAIQLERWEPAVKYYLAYTHLEPN 558
            |:.......|...|:.::...:|.::.:|:|........|..|::....:.|:..:.....|:|:
plant   576 AKRALARSAYNRGDFEKSKMLWEAAMALNSLYPDGWFALGAAALKARDVQKALDAFTFAVQLDPD 640

  Fly   559 GFESWNNLA-KALIKLGDKQRAHRVLGEALKCNYSNWKVWENYMLVSVDTSHWDDAMRAYQRMAE 622
            ..|:|||:| ..:||...|: :.....||||....:|::|||:..|::|..:.|.|..|.|::.:
plant   641 NGEAWNNIACLHMIKKKSKE-SFIAFKEALKFKRDSWQMWENFSHVAMDVGNIDQAFEAIQQILK 704

  Fly   623 L-KQHYLDQEVLTRIVYGVSKEDPAGSS------------------------ALIKRLIKLLG-- 660
            : |...:|..:|.||:..:.|.:.|..|                        |..:|.::|||
plant   705 MSKNKRVDVVLLDRIMTELEKRNSACKSSSSSTETEASSDESTETKPCTATPAETQRQLELLGKV 769

  Fly   661 -QQSIQHGNEPLVWELAALVAQTPLKK-----AEKLVKSYRAYTPKHLGWETK---SEHALKALD 716
             ||.::..:...:|.|.|..::  :|.     :|.|:|..|:|....: |:.|   .:.|..:|:
plant   770 IQQIVKTESTAEIWGLYARWSR--IKGDLTVCSEALLKQVRSYQGSEV-WKDKERFKKFARASLE 831

  Fly   717 LCLEVCDLSVAAITEHIQEESEVMITSQLNSARLAGTSCLNALKRAINVDVSAEQTAKVEQLEKR 781
            ||....::|.:     |..:.| :.|::::        ..|.:|:|   .||...:.::::||..
plant   832 LCRVYMEISAS-----IGSKRE-LFTAEMH--------LKNTIKQA---TVSFLDSEELKELESC 879

  Fly   782 IEDLTKIVQE 791
            :|::..::|:
plant   880 LEEVRNVMQK 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5290	NP_649026.1	TPR_11	493..557	CDD:290150	10/63 (16%)
		TPR repeat	493..520	CDD:276809	4/26 (15%)
		TPR repeat	525..555	CDD:276809	3/29 (10%)
		TPR_11	528..590	CDD:290150	17/62 (27%)
		TPR repeat	560..588	CDD:276809	10/28 (36%)
		TPR repeat	594..622	CDD:276809	10/27 (37%)
AT5G17270	NP_197229.1	TPR repeat	486..510	CDD:276809	6/23 (26%)
		TPR repeat	511..541	CDD:276809	8/29 (28%)
		TPR repeat	574..602	CDD:276809	4/27 (15%)
		TPR_11	575..639	CDD:290150	10/63 (16%)
		TPR_1	608..641	CDD:278916	5/32 (16%)
		TPR repeat	608..636	CDD:276809	3/27 (11%)
		TPR repeat	641..671	CDD:276809	11/30 (37%)
		TPR_11	643..707	CDD:290150	22/64 (34%)
		TPR repeat	676..704	CDD:276809	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2064
eggNOG	1	0.900	-	-		E1_KOG1128
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I1654
OMA	1	1.010	-	-		QHG54354
OrthoDB	1	1.010	-	-		D1039489at2759
OrthoFinder	1	1.000	-	-		FOG0003507
OrthoInspector	1	1.000	-	-		otm2689
orthoMCL	1	0.900	-	-		OOG6_101869
Panther	1	1.100	-	-	LDO	PTHR16193
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2880
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840