DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5290 and Ttc27

DIOPT Version :9

Sequence 1:	NP_649026.1	Gene:	CG5290 / 39998	FlyBaseID:	FBgn0036772	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_690030.3	Gene:	Ttc27 / 74196	MGIID:	1921446	Length:	847	Species:	Mus musculus

Alignment Length:	832	Identity:	253/832 - (30%)
Similarity:	397/832 - (47%)	Gaps:	99/832 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DIFSEYYICNFNDAVTVEDLPADETLRQLWTRQKLWTIDELREILQRWQEHVKPDPNDNPTSQLK 68
            |.:.|..|.||.|..|  ||...|       ||:|
Mouse    71 DSYLEKQIVNFLDCST--DLEEIE-------RQQL------------------------------ 96

  Fly    69 DFLLLIFA---FVQNSFTGPFDKLEEYQQIHSEL-----ELEKLDA--LEKLKASGEELNPNVKS 123
            .|||.:.:   |||:::|||...|.....:.|.|     |::.|||  :..|...||.:......
Mouse    97 VFLLGVSSLQLFVQSNWTGPLVDLHPQDFLPSGLLEQFSEVKGLDAIIMGLLILDGESVYSLTSK 161

  Fly   124 VELLLIAREILEGLLENHPESKVLIWWRLRLICLHQHVLDDLAASLYEQFKSAAGHLQAHFNQFE 188
            ..||||||.||..:.......:.|.||.||.:.:||.:|::.:..|:...|:....:....|.||
Mouse   162 PILLLIARIILVNIRHKLTALQSLPWWTLRYVNIHQQLLEERSPQLFALAKNCIDQVMKQENLFE 226

  Fly   189 ---SRELQSLLLLELANGYLQFHRSEIASQILDELCKHLQVELKVEGLLGVRTKFQQKALPQLCL 250
               .|.|.....||.|:.:|.::..:.|...........::|:.:.|.||.||:||:..:.||.:
Mouse   227 GDSGRLLAIQFHLECAHVFLYYYEYKEAKDQFSTAKDISKLEIDLTGALGKRTRFQENYVAQLIV 291

  Fly   251 KVEHLNEQQP----LPPAVQTNETTKLPKLLLLEDDTRLERIRFVELKDNEVMTLPSVLQ---AL 308
            .|.. .|..|    ..||....|.  |.|.|.|.|||.|..|:   |.|:|...:|.:..   |:
Mouse   292 DVRR-KEAVPFSCEFSPAPTPQEC--LAKNLELNDDTVLNEIK---LADSERFQMPDLCAEELAV 350

  Fly   309 VLAKVKQLKRSTPKDRLADEQLEPYTQTLLYQEHGP--FQVRQSALLLNCLQESNQRRTVERSWK 371
            ||......:::.|..:|.:|:|..:|..||.|   |  :.::.|||:|....|....|.|||:.:
Mouse   351 VLGVCTNFQKNNPVHKLTEEELLAFTSCLLSQ---PKFWAIQMSALILRTKLERGSTRRVERAMR 412

  Fly   372 QCEECVKLLDTSEEE-LSLRSRLSYGFAAHLSPKWQVQLQLVDLLRSLGMTKTALDICLRIHAWQ 435
            |.:   .|.|..|:: .|:..||...:...:.|.|.||.||..||..||.|.:||.|..::..|:
Mouse   413 QTQ---ALADQFEDKATSVLERLKIFYCCQVPPHWAVQRQLAGLLFELGCTSSALQIFEKLEMWE 474

  Fly   436 QVIECYTSLELRHKAAEIIRQELEKKPTALLYCLLGDAIDDPSFYEQAWLYSKKTSGKAQAYWGN 500
            .|:.|:.......||.||:|||||||.|..|||||||.:.|.|.|::||..|:..|.:||.....
Mouse   475 DVVICHERAGRHGKAEEILRQELEKKETPGLYCLLGDVLQDHSCYDKAWELSRHRSARAQRSKAL 539

  Fly   501 HFYRSADYAQAMDHFEISLEINNLQEAILLRCGYCAIQLERWEPAVKYYLAYTHLEPNGFESWNN 565
            ...|:.::.:.::.||.|::||.:|..:....|...:.||.:..:.|.:.....|||:..|:|||
Mouse   540 LHLRNKEFRECVECFERSVKINPMQLGVWFSLGCAYLALEDYGGSAKAFQRCVTLEPDNAEAWNN 604

  Fly   566 LAKALIKLGDKQRAHRVLGEALKCNYSNWKVWENYMLVSVDTSHWDDAMRAYQRMAELKQHYLDQ 630
            |:.:.|:|..|.:|.|.|.|||||||.:|::||||:|.|.|...:.:|::||.|:.:|:..|.|.
Mouse   605 LSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFGEAIKAYHRLLDLRDKYKDI 669

  Fly   631 EVLTRIVYGVSKE--DPAG--SSALIKRLIKLLGQQSIQHGNEPLVWELAALV-----AQTP--- 683
            :||..:|..|..:  |.:|  :|:|..:|.:|.|:.:.:..|:..||.|.|.|     ::.|
Mouse   670 QVLKILVQAVVNDMTDRSGAVASSLKGKLQELFGRITSRVTNDGEVWRLYAQVHGNGQSEKPDEN 734

  Fly   684 LKKAEKLVKSYRAYTPKHLGWETKSEHALKALDLCLEVCDLSV-AAITEHIQEESEVMITSQLNS 747
            .|..:.|.|:|:..|.... ||..:....:.:...:.:..::: .|.::.|.:|:    ...|:|
Mouse   735 DKAFQCLSKAYKCDTQSSC-WEKDATAFKEVVQRAIGLAHVAMKCAESKSIPQEA----VQTLSS 794

  Fly   748 ARLAGTSCLNALKR----AINVDVSAE---QTAKVEQLEKRIEDLTKIVQER 792
            .||.....|:..|:    .::.:||.|   :.|.|..||..::||:..::.|
Mouse   795 VRLNLRGLLSKAKQNFTDVVSGEVSGELASEIAAVNALEAELQDLSNQLRNR 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5290	NP_649026.1	TPR_11	493..557	CDD:290150	14/63 (22%)
		TPR repeat	493..520	CDD:276809	6/26 (23%)
		TPR repeat	525..555	CDD:276809	5/29 (17%)
		TPR_11	528..590	CDD:290150	22/61 (36%)
		TPR repeat	560..588	CDD:276809	13/27 (48%)
		TPR repeat	594..622	CDD:276809	12/27 (44%)
Ttc27	NP_690030.3	TPR 1	457..490		10/32 (31%)
		TPR 2	496..529		19/32 (59%)
		TPR_11	530..596	CDD:290150	15/65 (23%)
		TPR 3	531..564		8/32 (25%)
		TPR repeat	531..559	CDD:276809	6/27 (22%)
		TPR repeat	564..594	CDD:276809	5/29 (17%)
		TPR 4	565..598		7/32 (22%)
		TPR_11	567..629	CDD:290150	22/61 (36%)
		TPR repeat	599..627	CDD:276809	13/27 (48%)
		TPR 5	600..632		18/31 (58%)
		TPR 6	633..666		13/32 (41%)
		TPR repeat	633..661	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849618
Domainoid	1	1.000	193	1.000	Domainoid score	I3195
eggNOG	1	0.900	-	-		E1_KOG1128
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41191
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2708
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54354
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003507
OrthoInspector	1	1.000	-	-		oto92580
orthoMCL	1	0.900	-	-		OOG6_101869
Panther	1	1.100	-	-	LDO	PTHR16193
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1949
SonicParanoid	1	1.000	-	-		X2880
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790