DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5290 and ttc27

DIOPT Version :9

Sequence 1:	NP_649026.1	Gene:	CG5290 / 39998	FlyBaseID:	FBgn0036772	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_775392.2	Gene:	ttc27 / 317640	ZFINID:	ZDB-GENE-030102-1	Length:	839	Species:	Danio rerio

Alignment Length:	803	Identity:	245/803 - (30%)
Similarity:	380/803 - (47%)	Gaps:	86/803 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DELREILQRWQEHVKPDPNDNPTSQLKDFLLLIFA-----FVQNSFTGPFDKL-------EEYQQ 94
            |.:...|:|.......|..:...|..:..||.:..     |.|:::|||..:|       |...|
Zfish    59 DSIEAYLERQVLSYLSDATEEQRSHREVALLAVAVGCLNLFAQSNWTGPPVELHVSDVLPEALLQ 123

  Fly    95 IHSELELEKLDALEKLKASGEELNPNVKSVELLLIAREILEGLLENHPESKVLIWWRLRLICLHQ 159
            ..|:........|..|:..||.:...|.:..|||:.|.|...........::|.||.||.:.|||
Zfish   124 NFSQPAALSTALLSSLQLDGESVYSLVSNPLLLLLTRVIFVNCAAKLESLQLLPWWTLRYVALHQ 188

  Fly   160 HVLDDLAASLYEQFKSAAGHLQAHFNQFESRELQSLLL---LE---LANGYLQFHRSEIASQILD 218
            .:|::.:..|.....|....:......|.|...::|.:   ||   :...|.::|:::
Zfish   189 QILEERSPQLLNLMLSCIEKVCKCDELFSSNAHRNLAIQFHLECSYICLTYYEYHKAK------- 246

  Fly   219 ELCKHLQ-------VELKVEGLLGVRTKFQQKALPQLCLKVEH------LNEQQPLPPAVQTNET 270
               :|||       :::.:.|.||.||:||:..|.||.|.|:.      .|.:.|        .:
Zfish   247 ---EHLQTARDLSGLDVNMTGALGKRTRFQENFLAQLILDVKRKDNSPFYNSESP--------SS 300

  Fly   271 TKLPKLLL-----LEDDTRLERIRFVELKDNEVMTLPSVLQALVLAKVKQLKRSTPKDRLADEQL 330
            |..||.||     |.|||.|.:|...|..::|:..|.:..||.:||.....:::.|..:|.||:|
Zfish   301 TPTPKELLPKDHQLSDDTVLNQINLAEPSEHELPDLSAEEQAFILATCTDFQKNNPVHKLNDEEL 365

  Fly   331 EPYTQTLLYQEHGP--FQVRQSALLLNCLQESNQRRTVERSWKQCEECVKLLDTSEEELSLRSRL 393
            ..:|..||.|   |  :.|..::|.|....|....|.|||:..|.:..|...  ||::..:..||
Zfish   366 LAFTTCLLSQ---PKFWAVEVTSLCLRTKLERGSSRRVERAMMQTQTLVDFF--SEKDCPVTERL 425

  Fly   394 SYGFAAHLSPKWQVQLQLVDLLRSLGMTKTALDICLRIHAWQQVIECYTSLELRHKAAEIIRQEL 458
            ...::....|.|.:|.||..||..||:|.:||.|..|:..|:..:.|...:....||.||:|:||
Zfish   426 KMFYSCRAPPLWDLQRQLASLLTDLGLTSSALLIYERLELWEDAVVCLERMGQHGKAEEILRREL 490

  Fly   459 EKKPTALLYCLLGDAIDDPSFYEQAWLYSKKTSGKAQAYWGNHFYRSADYAQAMDHFEISLEINN 523
            |||.|..|||||||.:.||.:|::||..||..|.:||.....|..|..::.|.::.||.||:||:
Zfish   491 EKKETPSLYCLLGDVLKDPQYYDRAWELSKHRSARAQRSKALHHLRHREFQQCVECFERSLQINS 555

  Fly   524 LQEAILLRCGYCAIQLERWEPAVKYYLAYTHLEPNGFESWNNLAKALIKLGDKQRAHRVLGEALK 588
            :|..:....|.....||.:|.|.:.:.....|||:..|:||||:.|.|||..|::|.|.|.||||
Zfish   556 MQLGVWFSLGCAYFALESYEGAARAFQRCVGLEPDNSEAWNNLSTAYIKLRVKEKAFRTLQEALK 620

  Fly   589 CNYSNWKVWENYMLVSVDTSHWDDAMRAYQRMAELKQHYLDQEVLTRIVYGV--SKEDPAGSSAL 651
            |||..|::|||::.|.||...:.:|:|||.|:.|||..|.|.|||..:|..|  :..|..|..|.
Zfish   621 CNYERWQIWENFIAVCVDLGEFSEAIRAYHRLMELKDKYKDVEVLEILVQAVVDNLTDHRGEQAS 685

  Fly   652 IKR--LIKLLGQQSIQHGNEPLVWELAALV--------AQTPLKKAEKLVKSYRAYTPKHLGWET 706
            |.|  |.:|||:.|.:...:..:|:..|.:        |:...|..:.|.|::|..| :..|||.
Zfish   686 ILRPKLQELLGRVSSRCSTDAQIWKQYARLYGDGHSNNAEDNEKALQFLSKAHRCET-QAAGWEK 749

  Fly   707 KSEHALKALDLCLEVCDLSVAAITEHIQEESEVMITSQLNSARLAGTSCLNALKRAINVDVSA-- 769
            .:......:....::.::|::........:..:.:   |:||||:..| |....|.:..||:.
Zfish   750 DTGSFKSVVKGARDMANVSISCSRSKRSPQEALQL---LSSARLSLKS-LTTKARQLYTDVATGE 810

  Fly   770 ------EQTAKVEQLEKRIEDLT 786
                  :...::|||...|:||:
Zfish   811 LHDDLRDDVIELEQLITEIQDLS 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5290	NP_649026.1	TPR_11	493..557	CDD:290150	18/63 (29%)
		TPR repeat	493..520	CDD:276809	8/26 (31%)
		TPR repeat	525..555	CDD:276809	6/29 (21%)
		TPR_11	528..590	CDD:290150	25/61 (41%)
		TPR repeat	560..588	CDD:276809	15/27 (56%)
		TPR repeat	594..622	CDD:276809	12/27 (44%)
ttc27	NP_775392.2	TPR_11	523..589	CDD:290150	19/65 (29%)
		TPR repeat	524..552	CDD:276809	8/27 (30%)
		TPR_11	560..622	CDD:290150	25/61 (41%)
		TPR_1	560..591	CDD:278916	8/30 (27%)
		TPR repeat	560..586	CDD:276809	5/25 (20%)
		TPR repeat	591..621	CDD:276809	16/29 (55%)
		TPR repeat	626..654	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595368
Domainoid	1	1.000	201	1.000	Domainoid score	I2964
eggNOG	1	0.900	-	-		E1_KOG1128
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41191
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2539
OMA	1	1.010	-	-		QHG54354
OrthoDB	1	1.010	-	-		D1039489at2759
OrthoFinder	1	1.000	-	-		FOG0003507
OrthoInspector	1	1.000	-	-		otm26571
orthoMCL	1	0.900	-	-		OOG6_101869
Panther	1	1.100	-	-	LDO	PTHR16193
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2880
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770