DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr92 and Bub3

DIOPT Version :9

Sequence 1:	NP_649025.1	Gene:	Wdr92 / 39997	FlyBaseID:	FBgn0036771	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001287587.1	Gene:	Bub3 / 43490	FlyBaseID:	FBgn0025457	Length:	326	Species:	Drosophila melanogaster

Alignment Length:	339	Identity:	70/339 - (20%)
Similarity:	130/339 - (38%)	Gaps:	108/339 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VILGSKANGH-------GIMDIYELNQDKLVKVKSVEKKVAFKCGTFGAASLRNRHMAIGDFEGR 88
            |..|.|:|.:       |.:..|::..::| :.|.|:......|     |.:...|:..|..:.:
  Fly    19 VKFGPKSNQYMAASSWDGTLRFYDVPANQL-RQKFVQDAPLLDC-----AFMDIVHVVSGSLDNQ 77

  Fly    89 LQVLDM-----------EQPDLPVYNVKAHNGIINTIDAIGGTQIDCGAPEIVTGSRDGAVKVWD 142
            |::.|:           |:|...|.:.:..|||:                   |||.|..||:||
  Fly    78 LRLFDVNTQAESIIGAHEEPIRCVEHAEYVNGIL-------------------TGSWDNTVKLWD 123

  Fly   143 IRQGQAPVVDMSPPPQMGDGVNNSSGRRDCWAVAFGNTYN---AEERIVAAGYDNGDLKIFDLRS 204
            :|:.:.          :|....|:           |..|:   .:|:||.|..|...| |:|||.
  Fly   124 MREKRC----------VGTFEQNN-----------GKVYSMSVIDEKIVVATSDRKVL-IWDLRK 166

  Fly   205 LS---VRWEATMKNGICGLEFDRRDIPM--NK--LAVTTLEGGLLV--FDMRTQHPTKGFSYVEE 260
            :.   ::.|:::|       :..|.|.:  ||  ..::::||.:.|  .|...:...:.|::...
  Fly   167 MDSYIMKRESSLK-------YQTRCIRLFPNKEGYVMSSIEGRVAVEYLDHDPEVQRRKFAFKCH 224

  Fly   261 RNAGRSVGTNGVISGPKATVWVVRHLPQNR--DLFLTGGGTGSIRLW------------QYEYPD 311
            ||..:::          ..::.|..|..:.  ..|.|||..|.:.:|            :|:...
  Fly   225 RNREQNI----------EQIYPVNALSFHNVYQTFATGGSDGIVNIWDGFNKKRLCQFHEYDTSI 279

  Fly   312 RRVIDDSDGNKLGV 325
            ..:...|||:.|.:
  Fly   280 STLNFSSDGSALAI 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr92	NP_649025.1	WD40	<2..354	CDD:225201	70/339 (21%)
		WD40	77..366	CDD:295369	59/286 (21%)
		WD40 repeat	111..165	CDD:293791	10/53 (19%)
		WD40 repeat	173..210	CDD:293791	12/42 (29%)
		WD40 repeat	217..256	CDD:293791	8/44 (18%)
		WD40 repeat	280..333	CDD:293791	13/60 (22%)
		WD40 repeat	342..366	CDD:293791
Bub3	NP_001287587.1	WD40	<10..296	CDD:225201	70/339 (21%)
		WD40	16..262	CDD:295369	64/306 (21%)
		WD40 repeat	16..53	CDD:293791	8/34 (24%)
		WD40 repeat	59..93	CDD:293791	6/38 (16%)
		WD40 repeat	98..134	CDD:293791	14/64 (22%)
		WD40 repeat	141..175	CDD:293791	11/34 (32%)
		WD40 repeat	182..222	CDD:293791	9/39 (23%)
		WD40 repeat	237..283	CDD:293791	9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10971
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940