DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr92 and DNAAF10

DIOPT Version :9

Sequence 1:	NP_649025.1	Gene:	Wdr92 / 39997	FlyBaseID:	FBgn0036771	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_612467.1	Gene:	DNAAF10 / 116143	HGNCID:	25176	Length:	357	Species:	Homo sapiens

Alignment Length:	372	Identity:	210/372 - (56%)
Similarity:	264/372 - (70%)	Gaps:	21/372 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DKPQLIEHLHEALNYTVYDTKWVPLSAKFVILGSKANGHGIMDIYELNQDKLVKVKSVEKKVAFK 66
            :|||:|.|:.:..||||:|.||||.|||||.:|:.|.|.|::.:||:....|..::.:||....|
Human     5 EKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIK 69

  Fly    67 CGTFGAASLRNRHMAIGDFEGRLQVLDMEQPDLPVYNVKAHNGIINTIDAIGGTQIDCGAPEIVT 131
            ||||||.||:.|::|.|||.|.|.:.::|.|::|||:||.|..|||.||.|||..|..|||||||
Human    70 CGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVT 134

  Fly   132 GSRDGAVKVWDIRQGQAPVVDMSPPPQMGDGVNNSSGRRDCWAVAFGNTYNAEERIVAAGYDNGD 196
            |||||.|||||.||...||.:|.|.    .|.|    :||||.|||||.||.|||:|.|||||||
Human   135 GSRDGTVKVWDPRQKDDPVANMEPV----QGEN----KRDCWTVAFGNAYNQEERVVCAGYDNGD 191

  Fly   197 LKIFDLRSLSVRWEATMKNGICGLEFDRRDIPMNKLAVTTLEGGLLVFDMRTQHPTKGFSYVEER 261
            :|:||||::::|||..:|||:|.|||||:||.||||..|:|||...|||||||||||||:.|.|:
Human   192 IKLFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEK 256

  Fly   262 NAGRSVGTNGVISGPKATVWVVRHLPQNRDLFLTGGGTGSIRLWQYEYPDRRVIDDSDGNKLGVA 326
                         ..|:|||.||||||||:||||.||.|.:.||:||||.:|...||:|.::|||
Human   257 -------------AHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVA 308

  Fly   327 GALNMLSAATLSSQPVHCFDWHPDKLGLAVCGAFDQSVRVLITTKLN 373
            |::::|...|||:||:...||.|||.||.||.:|||:|||||.||||
Human   309 GSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLN 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr92	NP_649025.1	WD40	<2..354	CDD:225201	194/351 (55%)
		WD40	77..366	CDD:295369	165/288 (57%)
		WD40 repeat	111..165	CDD:293791	32/53 (60%)
		WD40 repeat	173..210	CDD:293791	25/36 (69%)
		WD40 repeat	217..256	CDD:293791	28/38 (74%)
		WD40 repeat	280..333	CDD:293791	31/52 (60%)
		WD40 repeat	342..366	CDD:293791	13/23 (57%)
DNAAF10	NP_612467.1	WD40	21..348	CDD:421866	194/347 (56%)
		WD40 repeat	21..64	CDD:293791	18/42 (43%)
		WD 1	63..105		21/41 (51%)
		WD40 repeat	69..109	CDD:293791	22/39 (56%)
		WD40 repeat	114..157	CDD:293791	29/42 (69%)
		WD 2	115..154		27/38 (71%)
		WD 3	162..205		29/46 (63%)
		WD40 repeat	168..207	CDD:293791	27/38 (71%)
		WD 4	207..249		29/41 (71%)
		WD40 repeat	212..256	CDD:293791	30/43 (70%)
		WD 5	257..297		26/39 (67%)
		WD40 repeat	262..318	CDD:293791	32/55 (58%)
		WD 6	319..357		25/37 (68%)
		WD40 repeat	324..348	CDD:293791	13/23 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146372
Domainoid	1	1.000	219	1.000	Domainoid score	I2653
eggNOG	1	0.900	-	-		E1_28J7X
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16321
Inparanoid	1	1.050	436	1.000	Inparanoid score	I1699
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54039
OrthoDB	1	1.010	-	-		D1030954at2759
OrthoFinder	1	1.000	-	-		FOG0007111
OrthoInspector	1	1.000	-	-		oto90087
orthoMCL	1	0.900	-	-		OOG6_103914
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770