DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr92 and Dnaaf10

DIOPT Version :9

Sequence 1:	NP_649025.1	Gene:	Wdr92 / 39997	FlyBaseID:	FBgn0036771	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_849240.1	Gene:	Dnaaf10 / 103784	MGIID:	2144224	Length:	357	Species:	Mus musculus

Alignment Length:	373	Identity:	212/373 - (56%)
Similarity:	269/373 - (72%)	Gaps:	21/373 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DKPQLIEHLHEALNYTVYDTKWVPLSAKFVILGSKANGHGIMDIYELNQDKLVKVKSVEKKVAFK 66
            :|||:|.|:.:.|||||:|:||||.|||||.:|:.|.|.|::.:||:.:..|..::.:||....|
Mouse     5 EKPQIIVHIQKGLNYTVFDSKWVPCSAKFVTMGNFARGTGVIQVYEIQRGDLKLLREIEKAKPIK 69

  Fly    67 CGTFGAASLRNRHMAIGDFEGRLQVLDMEQPDLPVYNVKAHNGIINTIDAIGGTQIDCGAPEIVT 131
            |||||||||:.|.:|.|||.|.|.:.::|.|::|||:||.|..||||||.:||..|..|||||||
Mouse    70 CGTFGAASLQQRFLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINTIDGVGGLGIGEGAPEIVT 134

  Fly   132 GSRDGAVKVWDIRQGQAPVVDMSPPPQMGDGVNNSSGRRDCWAVAFGNTYNAEERIVAAGYDNGD 196
            |||||.|||||.||.:.||.:|.|    ..|.|    :||||.|||||.||.|||:|.|||||||
Mouse   135 GSRDGTVKVWDPRQKEDPVANMEP----AQGEN----KRDCWTVAFGNAYNQEERVVCAGYDNGD 191

  Fly   197 LKIFDLRSLSVRWEATMKNGICGLEFDRRDIPMNKLAVTTLEGGLLVFDMRTQHPTKGFSYVEER 261
            :|:||||::|:|||..:|||:|.|||||:||.||||..|:|||...|||||||||||||:.|.|:
Mouse   192 IKLFDLRNMSLRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVTEK 256

  Fly   262 NAGRSVGTNGVISGPKATVWVVRHLPQNRDLFLTGGGTGSIRLWQYEYPDRRVIDDSDGNKLGVA 326
                         ..|:|||.||||||||::|||.||.||:.||:||||.:|...||:|.::|||
Mouse   257 -------------AHKSTVWQVRHLPQNREIFLTTGGAGSLHLWKYEYPTQRSKKDSEGLEMGVA 308

  Fly   327 GALNMLSAATLSSQPVHCFDWHPDKLGLAVCGAFDQSVRVLITTKLNT 374
            |::::|...|:|:||:...||.|||.||.||.:|||.|||||.|||.|
Mouse   309 GSVSLLQNVTVSTQPISSLDWSPDKRGLCVCSSFDQMVRVLIVTKLQT 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr92	NP_649025.1	WD40	<2..354	CDD:225201	196/351 (56%)
		WD40	77..366	CDD:295369	165/288 (57%)
		WD40 repeat	111..165	CDD:293791	32/53 (60%)
		WD40 repeat	173..210	CDD:293791	26/36 (72%)
		WD40 repeat	217..256	CDD:293791	28/38 (74%)
		WD40 repeat	280..333	CDD:293791	31/52 (60%)
		WD40 repeat	342..366	CDD:293791	13/23 (57%)
Dnaaf10	NP_849240.1	WD40	2..>348	CDD:225201	204/363 (56%)
		WD40	21..348	CDD:295369	195/347 (56%)
		WD40 repeat	21..64	CDD:293791	18/42 (43%)
		WD 1	63..105		22/41 (54%)
		WD40 repeat	69..109	CDD:293791	23/39 (59%)
		WD40 repeat	114..157	CDD:293791	29/42 (69%)
		WD 2	115..154		27/38 (71%)
		WD 3	162..205		30/46 (65%)
		WD40 repeat	168..207	CDD:293791	28/38 (74%)
		WD 4	207..249		29/41 (71%)
		WD40 repeat	212..256	CDD:293791	30/43 (70%)
		WD 5	257..297		26/39 (67%)
		WD40 repeat	262..318	CDD:293791	32/55 (58%)
		WD 6	319..357		24/38 (63%)
		WD40 repeat	324..348	CDD:293791	13/23 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836454
Domainoid	1	1.000	272	1.000	Domainoid score	I1806
eggNOG	1	0.900	-	-		E1_28J7X
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16321
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1641
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54039
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007111
OrthoInspector	1	1.000	-	-		oto93662
orthoMCL	1	0.900	-	-		OOG6_103914
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5686
SonicParanoid	1	1.000	-	-		X5200
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790