DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr92 and dnaaf10

DIOPT Version :9

Sequence 1:	NP_649025.1	Gene:	Wdr92 / 39997	FlyBaseID:	FBgn0036771	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001096516.1	Gene:	dnaaf10 / 100125149	XenbaseID:	XB-GENE-980477	Length:	358	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	202/375 - (53%)
Similarity:	265/375 - (70%)	Gaps:	25/375 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKPQLIEHLHEALNYTVYDTKWVPLSAKFVILGSKANGHGIMDIYELNQDKLVKVKSVEKKVAF 65
            ::|||:|.|:.:.:.||::|.||:|.|||||.:|:.|.|.|::.:||:.|.:...::..||....
Frog     5 LEKPQIIAHVQKPVTYTLFDCKWIPCSAKFVCVGNLARGSGVLQVYEIQQGEAKLLQEAEKPKPI 69

  Fly    66 KCGTFGAASLRNRHMAIGDFEGRLQVLDMEQPDLPVYNVKAHNGIINTIDAIGGTQIDCGAPEIV 130
            |||||||:||:.|::|.|||.|.|.:.::|.||.|||:.|.||.|||.||.:||..|..||||||
Frog    70 KCGTFGASSLQQRYLATGDFGGNLNIWNLEAPDTPVYSAKGHNEIINCIDGVGGVGIGEGAPEIV 134

  Fly   131 TGSRDGAVKVWDIRQGQAPVVDMSPPPQMGDGVNNSSG--RRDCWAVAFGNTYNAEERIVAAGYD 193
            ||||||.|||||.||...||.:|.|          ::|  :||||.||||:.||.:||:|.||||
Frog   135 TGSRDGTVKVWDPRQKDTPVANMEP----------AAGETKRDCWTVAFGHAYNEQERLVCAGYD 189

  Fly   194 NGDLKIFDLRSLSVRWEATMKNGICGLEFDRRDIPMNKLAVTTLEGGLLVFDMRTQHPTKGFSYV 258
            |||:|:||||::|||||..:|||:|.|||||:||.||||..|:|||...|||||||||:|||:.:
Frog   190 NGDIKLFDLRNMSVRWETNIKNGVCSLEFDRKDIVMNKLVATSLEGKFHVFDMRTQHPSKGFASM 254

  Fly   259 EERNAGRSVGTNGVISGPKATVWVVRHLPQNRDLFLTGGGTGSIRLWQYEYPDRRVIDDSDGNKL 323
            .|:             ..|:|:|.|||||||||:|:|.||.|::.||:||||.:|...|||...:
Frog   255 SEK-------------AHKSTIWQVRHLPQNRDVFMTSGGAGNLHLWKYEYPAQRSRKDSDDVDM 306

  Fly   324 GVAGALNMLSAATLSSQPVHCFDWHPDKLGLAVCGAFDQSVRVLITTKLN 373
            ||||::::|...|||:||:...||.|||.||.||.:|||:|||||.||||
Frog   307 GVAGSVSLLQNVTLSTQPISSMDWSPDKKGLCVCTSFDQTVRVLIVTKLN 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr92	NP_649025.1	WD40	<2..354	CDD:225201	186/353 (53%)
		WD40	77..366	CDD:295369	160/290 (55%)
		WD40 repeat	111..165	CDD:293791	30/53 (57%)
		WD40 repeat	173..210	CDD:293791	25/36 (69%)
		WD40 repeat	217..256	CDD:293791	27/38 (71%)
		WD40 repeat	280..333	CDD:293791	29/52 (56%)
		WD40 repeat	342..366	CDD:293791	13/23 (57%)
dnaaf10	NP_001096516.1	WD40 repeat	22..65	CDD:293791	16/42 (38%)
		WD40	26..349	CDD:330360	186/345 (54%)
		WD 1	64..106		22/41 (54%)
		WD40 repeat	70..110	CDD:293791	22/39 (56%)
		WD40 repeat	115..158	CDD:293791	28/42 (67%)
		WD 2	116..155		26/38 (68%)
		WD 3	163..206		28/42 (67%)
		WD40 repeat	169..208	CDD:293791	27/38 (71%)
		WD 4	208..250		28/41 (68%)
		WD40 repeat	213..257	CDD:293791	28/43 (65%)
		WD 5	258..298		24/39 (62%)
		WD40 repeat	263..319	CDD:293791	30/55 (55%)
		WD 6	320..358		25/37 (68%)
		WD40 repeat	325..349	CDD:293791	13/23 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1862
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16321
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1692
OMA	1	1.010	-	-		QHG54039
OrthoDB	1	1.010	-	-		D1030954at2759
OrthoFinder	1	1.000	-	-		FOG0007111
OrthoInspector	1	1.000	-	-		otm48589
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5686
SonicParanoid	1	1.000	-	-		X5200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110