DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and YGR125W

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_011641.1	Gene:	YGR125W / 853026	SGDID:	S000003357	Length:	1036	Species:	Saccharomyces cerevisiae

Alignment Length:	802	Identity:	155/802 - (19%)
Similarity:	284/802 - (35%)	Gaps:	243/802 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SPETKPLNNNNTNGNGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSS------LR 65
            ||.:..::::...|...|  |.|::                  :.|||...:|:..|      .|
Yeast   149 SPASSNVDDDRNRGLQNS--SLPEL------------------EDGYAGGYQSLRPSHNLRFRPR 193

  Fly    66 NCWRSWNFF-ALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGL 129
            |.|.....| :.|...:|                   |.....::||...::||
Yeast   194 NLWHMCTSFPSKFAHYLP-------------------AAVLGLLLNILDALSYG----------- 228

  Fly   130 YMAVFPVLAYMF--LGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATA 192
             |.:||:...:|  ||.:   .|..|.::::::..|   |:.             |..|..:...
Yeast   229 -MIIFPITEPVFSHLGPT---GISMFYISTIISQAV---YSG-------------GWSSFPSGIG 273

  Fly   193 SPLLLI----NSSALA---------DSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVN 244
            |.::.|    ::.|||         |.:.:|||..: :::|.|                 .|:|.
Yeast   274 SEMIEITPFYHTMALAIKEALAGNDDEIITTTIFCY-VISSML-----------------TGVVF 320

  Fly   245 LLMAFLRLGTLSSLLSEPLVNG-------FTTAAACHVVTAQLKDVLGISVPRHKGAF------- 295
            ..:..||||.:.......::.|       |.......|.|...|  ...|.|...|.|
Yeast   321 YALGKLRLGKIVGFFPRHILIGCIGGVGYFLIITGIEVTTRVAK--FEYSWPFFSGLFTDYDTLA 383

  Fly   296 ----KIIYTVIDVIKGVPQ-------------TNLVNFGFCMAVIAFMMICNEILKPRLSKKCR- 342
                .::.||  |:.|..:             ..||.|.|.:|:|           |.||....
Yeast   384 KWLLPVLLTV--VLIGTQRYFKNSLVLPSFYILTLVLFHFIVAII-----------PTLSLDALR 435

  Fly   343 -----FPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIA 402
                 ||:         ....|||::.|..:||:   |:...|....:|.:     :|:....|.
Yeast   436 QAGWIFPI---------ANSDSKWYDHYRLFNVH---KVHWSLVLQQIPTM-----MALTFFGIL 483

  Fly   403 IVTYSI-IMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQ 466
            .|..:: .::|.|...|   |:|  ::||.|.|..|...|....:......:.||:..:.|..|.
Yeast   484 HVPINVPALAMSLQMDK---YDV--DRELIAHGYSNFFSGLLGSVQNYLVYTNSVLFIRAGADSP 543

  Fly   467 IASLVSASLVVVTLMWIGP-FFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWIST 530
            .|..:..:| .:.:|.||| ..|.:|.|::..:|.:....:.::|. :..::|..:.|..|.:..
Yeast   544 FAGFLLIAL-TICIMIIGPVIISFIPICIVGSLIFLLGYELLVEAL-VDTWNKLNRFEYLTVVII 606

  Fly   531 FLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPG------IYMDLNQHRNAMQVP 589
            ...:.|.|..:|:::||.|:..:..:...|    |.....|..|      :|.|..|.:....:.
Yeast   607 VFTMGIFDFVLGIIVGILIACFSFLVDSTK----LQTINGEYNGNVARSTVYRDYVQTKFLDGIG 667

  Fly   590 E-VRIFRYSGSLNFATSLFFRRALYEAVGLDKIP-LTKVSSSNSNSPSKGSKSSYSPVSQNGGKA 652
            | :.:.:....|.|.|.:...         :||. |.::|:.::
Yeast   668 EQIYVLKLQNLLFFGTIISIE---------EKIERLLQISNKDA--------------------- 702

  Fly   653 INGKLEETSGAFKVLVLDFSMLG--HIDVAGCRTLTDLSKELKVRGARLLLAS--PVDRVYDTLV 713
                   |....|.|:|||..:.  :||.:.......:.:..:.:..:|:::|  ..||:|:...
Yeast   703 -------TKRRIKYLILDFKNINADNIDYSAAEGFNRIKRFTETKRIKLIISSIKERDRIYNAFN 760

  Fly   714 HSMALSEGPFEIFPTLHDCVEY 735
            :...|::  .|:|..|:..:|:
Yeast   761 NVGLLND--VELFADLNSALEW 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	138/714 (19%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	24/153 (16%)
YGR125W	NP_011641.1	SUL1	128..785	CDD:223732	155/802 (19%)
YGR125W	NP_011641.1	CAP_ED	910..1014	CDD:237999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810