Protein Alignment Prestin and SUL1

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_009853.3
• Gene: SUL1 / 852597
• SGDID: S000000498
• Length: 859
• Species: Saccharomyces cerevisiae
• Alignment Length: 852
• Identity: 190/852 - (22%)
• Similarity: 325/852 - (38%)
• Gaps: 178/852 - (20%)

  Fly     4 DKESPETKPLNNNNTNGNGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCW 68
            :.|:.|.:...:|....|.....||.|.....:...|||...:...:.......:....|::|..
Yeast    30 ESEAAENRDGLHNGDEENWKVNSSKQKFGVTKNELSDVLYDSIPAYEESTVTLKEYYDHSIKNNL 94

  Fly    69 RSWNFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAV 133
            .:.:..:....:.||::|.|.|:..... .|::||.||..:.:|..|:|..:|.:|...|||.:.
Yeast    95 TAKSAGSYLVSLFPIIKWFPHYNFTWGY-ADLVAGITVGCVLVPQSMSYAQIASLSPEYGLYSSF 158

  Fly   134 FPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLI 198
            .....|....|||.:.||..||.|:.||||:..........|             |...:|:
Yeast   159 IGAFIYSLFATSKDVCIGPVAVMSLQTAKVIAEVLKKYPEDQ-------------TEVTAPI--- 207

  Fly   199 NSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPL 263
                                             :||:|.|..|||...:..||||.|..|:|...
Yeast   208 ---------------------------------IATTLCLLCGIVATGLGILRLGFLVELISLNA 239

  Fly   264 VNGFTTAAACHVVTAQLKDVLGIS--VPRHKGAFKIIYTVIDVIKGVPQTNL-VNFGFCMAVIAF 325
            |.||.|.:|.:::..|:..::|.:  |...:..:|:   ||:.:|.:|.|.| ..||....||.:
Yeast   240 VAGFMTGSAFNIIWGQIPALMGYNSLVNTREATYKV---VINTLKHLPNTKLDAVFGLIPLVILY 301

  Fly   326 M--MICNEI----------LKPRLSKKCR-FPLPAE----LIMVIGGTLISKWF----NLYVDYN 369
            :  ..|...          .:|:::.:.: |...|:    .::::..|.|| |.    ....|..
Yeast   302 VWKWWCGTFGITLADRYYRNQPKVANRLKSFYFYAQAMRNAVVIVVFTAIS-WSITRNKSSKDRP 365

  Fly   370 VNPVGKIPSGLPEPVLPRL--DLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFA 432
            ::.:|.:||||.|..:.::  .|:..::.:..|..||.....:::..:|.:.:.|:|.|:|||.|
Yeast   366 ISILGTVPSGLNEVGVMKIPDGLLSNMSSEIPASIIVLVLEHIAISKSFGRINDYKVVPDQELIA 430

  Fly   433 MGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAG 497
            :|:.|::|..|...|...|.|||.::.:....:..:.:.:...|::.|..:...|..:|:..|:.
Yeast   431 IGVTNLIGTFFHSYPATGSFSRSALKAKCNVRTPFSGVFTGGCVLLALYCLTDAFFFIPKATLSA 495

  Fly   498 VIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPY 562
            |||.|:..:....|....|.|...|:..::|.|....|...|:.|:...:|.|...|.:|...|.
Yeast   496 VIIHAVSDLLTSYKTTWTFWKTNPLDCISFIVTVFITVFSSIENGIYFAMCWSCAMLLLKQAFPA 560

  Fly   563 SCLLGYMPEA----PGIYMDLN--------------QHRNAMQV---PEVRI--------FRYSG 598
            ...||.:..|    |.:..|::              |.::.::|   ||.:.        ..||.
Yeast   561 GKFLGRVEVAEVLNPTVQEDIDAVISSNELPNELNKQVKSTVEVLPAPEYKFSVKWVPFDHGYSR 625

  Fly   599 SLNFATS---------------------------LFFRRALYEAVGLDKIPLTKVSSSNSNSPSK 636
            .||..|:                           :.|.|...|......|.|.|.|....|.|.:
Yeast   626 ELNINTTVRPPPPGVIVYRLGDSFTYVNCSRHYDIIFDRIKEETRRGQLITLRKKSDRPWNDPGE 690

  Fly   637 -----------------GSKSSYSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRT 684
                             .:.:|..|:| ||..  ||:..| ....||:.||||.:..:|....::
Yeast   691 WKMPDSLKSLFKFKRHSATTNSDLPIS-NGSS--NGETYE-KPLLKVVCLDFSQVAQVDSTAVQS 751

  Fly   685 LTDLSKELKVRGARLL------LASP-------------VDRVYDTLVHSMALSEGPFEIFPTLH 730
            |.||.|.:.....|.:      :.||             .:..|..  .|:......|.:...|.
Yeast   752 LVDLRKAVNRYADRQVEFHFAGIISPWIKRSLLSVKFGTTNEEYSD--DSIIAGHSSFHVAKVLK 814

  Fly   731 DCVEYAN 737
            |.|:|.:
Yeast   815 DDVDYTD 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	175/766 (23%)
SUL1	NP_009853.3	Sulfate_transp	123..528	CDD:459995	112/457 (25%)
		STAS_SulP_like_sulfate_transporter	633..789	CDD:132913	31/159 (19%)