DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and AST56

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_565165.2	Gene:	AST56 / 844134	AraportID:	AT1G77990	Length:	677	Species:	Arabidopsis thaliana

Alignment Length:	763	Identity:	189/763 - (24%)
Similarity:	317/763 - (41%)	Gaps:	145/763 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKESPETKPLNNNNTNGNGGSVPSKPKIQPKYSIHRDVLTH---EVVIKQTGYAARDKSIPSSL- 64
            ::.||..:|::....|     .|..|      |:.::::.:   .|:.|:.....:.|:..|:|
plant    32 EEASPAEEPMSRWLIN-----TPEPP------SMWQELIGYIRTNVLAKKKHKRNKTKNSSSNLV 85

  Fly    65 RNCWRSWNFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGL 129
            .:|.:|         ..|||.|..||.... ...|::||.|:|.:.||..:.|..|||:....||
plant    86 YSCLKS---------AFPILSWGRQYKLNL-FKKDLMAGLTLASLCIPQSIGYANLAGLDPEYGL 140

  Fly   130 YMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASP 194
            |.:|.|.|.|..:|||:.::||..||.|::.:.:|
plant   141 YTSVVPPLIYSTMGTSRELAIGPVAVVSLLLSSMV------------------------------ 175

  Fly   195 LLLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLL 259
                  ..|.|.|:                |||...::..::....|....:....|||.|...|
plant   176 ------RDLQDPVT----------------DPIAYRKIVFTVTFFAGAFQAIFGLFRLGFLVDFL 218

  Fly   260 SEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGV------PQTNLVNFGF 318
            |...:.||...||..:...|||.:.|::...:|      ..|:.|:..|      |...| ||..
plant   219 SHAALVGFMAGAAIVIGLQQLKGLFGLTHFTNK------TDVVSVLSSVFHSLHHPWQPL-NFVI 276

  Fly   319 CMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYV----DYNVNPVGKIPSG 379
            ..:.:.|:::...|.| |.:|....|..|.||.|:..|||     :|:    ...|..|..|..|
plant   277 GSSFLIFILLARFIGK-RNNKLFWIPAMAPLISVVLATLI-----VYLSNAESRGVKIVKHIKPG 335

  Fly   380 LPEPVL-------PRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGN 437
            ..:..:       |.|..:.|:.:.|   ||:..:..:::|.:||...||.:..|:|:.|||..|
plant   336 FNQLSVNQLQFKSPHLGQIAKIGLIS---AIIALTEAIAVGRSFATIKGYRLDGNKEMMAMGFMN 397

  Fly   438 MVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVA 502
            :.|...||.....|.||:.:....|..:.::::|.|..|:::|..:..|....|..:||.:|:.|
plant   398 IAGSLSSCYVATGSFSRTAVNFSAGCETVVSNIVMAITVMISLEVLTRFLYFTPTAILASIILSA 462

  Fly   503 LKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLG 567
            | |..:.........|..||:....|:.|..|:...::||||:.:.||...:.:..::|....||
plant   463 L-PGLIDVSGALHIWKLDKLDFLVLIAAFFGVLFASVEIGLLLAVGISFARIMLSSIRPSIEALG 526

  Fly   568 YMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGS-LNFATSLFFRRALYEAVGLDKIPLTKVSSSNS 631
            .:.:. .|:.|:||:..|.:...:...|.|.. |.||.:.|.|         |:|       .||
plant   527 RLSKT-DIFGDINQYPMANKTAGLLTLRISSPLLCFANANFIR---------DRI-------LNS 574

  Fly   632 NSPSKGSKSSYSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRG 696
            ....:|.::....:.:||              .:|::||.|.:..:|.:|...|.:|.:||....
plant   575 VQEIEGEENEQEVLKENG--------------LQVVILDMSCVMGVDTSGVFALEELHQELASND 625

  Fly   697 ARLLLASPVDRVYDTLVHSMALSEGPFE-IFPTLHDCVE-YANACRTA 742
            .||::|||..||...|..:....:...| |:.|:.:.|: |..|..|:
plant   626 IRLVIASPRWRVLHKLKRAKLDEKIKTENIYMTVGEAVDIYVRARSTS 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	171/667 (26%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	36/149 (24%)
AST56	NP_565165.2	sulP	94..662	CDD:273284	171/668 (26%)
AST56	NP_565165.2	STAS	540..662	CDD:279997	36/151 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55446
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.780