DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and SULTR4;2

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_187858.1	Gene:	SULTR4;2 / 820431	AraportID:	AT3G12520	Length:	677	Species:	Arabidopsis thaliana

Alignment Length:	741	Identity:	189/741 - (25%)
Similarity:	312/741 - (42%)	Gaps:	170/741 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TGYAARDKSIP------------SSLRNC-----------W----RSWNFFALFTGVIPILQWLP 88
            |..::..|:||            ||..:|           |    :...||.....:.|...|:.
plant    10 TASSSSSKAIPVKIIPLQYPDSTSSDPHCHSIPFNDFFSRWTAKIKRMTFFDWIDAIFPCFLWIR 74

  Fly    89 QYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTF 153
            .|...:....|::||.||.||.:|..|:|..|||:....|||.:..||..|...|:|:.:::|..
plant    75 TYRWHQYFKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPV 139

  Fly   154 AVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLL 218
            |:.|::.                                       |:||:..|
plant   140 ALVSLLV---------------------------------------SNALSGIV----------- 154

  Fly   219 NSTLNADPITKI--EVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLK 281
                  ||..::  |:|..|||.|||...:|.|||||.|...:|..:::|||||:|..:..:|||
plant   155 ------DPSEELYTELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLK 213

  Fly   282 DVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRF--- 343
            ..||.||.|   :.||:..:..:|.|..|.....|.....::..:::...:.|.:  |:.||
plant   214 YFLGYSVSR---SSKIMPVIDSIIAGADQFKWPPFLLGCTILVILLVMKHVGKAK--KELRFIRA 273

  Fly   344 --PLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTY 406
              ||....:    ||:|:|.|:   ..::..||.||.|||:...|:.....|:.:.:.|: |...
plant   274 AGPLTGLAL----GTIIAKVFH---PPSITLVGDIPQGLPKFSFPKSFDHAKLLLPTSAL-ITGV 330

  Fly   407 SIIMSMGL--TFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIAS 469
            :|:.|:|:  ..|.|:.||:..|.|||.:|:.|:.|..||..|...|.|||.:..::...:.::.
plant   331 AILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSAVNSESEAKTGLSG 395

  Fly   470 LVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALK-------PMFMQAKELKKFSKQGKLEMFTW 527
            ||:..::..:|:::.|.|..:|:|.||.::|.|:.       .:|:...:.:.|:        .|
plant   396 LVTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDFT--------LW 452

  Fly   528 ISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVR 592
            ..|....:...|:||:|||:..||..:..:...|:..:||.:| ...:|.::.|:..|.....:.
plant   453 TITSTTTLFFGIEIGVLIGVGFSLAFVIHESANPHIAVLGRLP-GTTVYRNMKQYPEAYTYNGIV 516

  Fly   593 IFRYSGSLNFATSLFFRRALYE-AVGLDKIPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAINGK 656
            |.|....:.||...:.:..|.| .|.:||            ..|||....
plant   517 IVRIDAPIYFANISYIKDRLREYEVAIDK------------HTSKGPDME--------------- 554

  Fly   657 LEETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLVHSMALSEG 721
                  ....::|:.|.:.:||.:....|.||.:|.|.||.:|.:::|...|..||..:     |
plant   555 ------RIYFVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAISNPNKEVLLTLARA-----G 608

  Fly   722 PFEI------FPTLHD----CVEYAN 737
            ..|:      |..:||    ||.|.|
plant   609 IVELIGKEWFFVRVHDAVQVCVHYVN 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	173/671 (26%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	32/154 (21%)
SULTR4;2	NP_187858.1	sulP	68..625	CDD:273284	174/672 (26%)
		HCO3_cotransp	<165..481	CDD:304903	101/336 (30%)
		STAS_SulP_like_sulfate_transporter	506..622	CDD:132913	32/153 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55446
OrthoDB	1	1.010	-	-		D690428at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.790