Protein Alignment Prestin and Slc26a5

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_109652.3
• Gene: Slc26a5 / 80979
• MGIID: 1933154
• Length: 744
• Species: Mus musculus
• Alignment Length: 757
• Identity: 227/757 - (29%)
• Similarity: 373/757 - (49%)
• Gaps: 108/757 - (14%)

  Fly    29 PKIQPKYSIHRDVLTHEVVIKQTGYAARDK---SIPSSLRNCW-----RSWNFFALFTGVIPILQ 85
            |....:|.:.|.:.:|.|:  |.....:||   ||...|:..:     :..|...:|   :||.:
Mouse    10 PAETQRYYVERPIFSHPVL--QERLHVKDKVTESIGDKLKQAFTCTPKKIRNIIYMF---LPITK 69

  Fly    86 WLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISI 150
            |||.|..:..:.||:::|.:..::.:|.|:|:.:||.|....|||.:.:||:.|.|.|||:||||
Mouse    70 WLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPVFGLYSSFYPVIMYCFFGTSRHISI 134

  Fly   151 GTFAVASMMTAKVVDTYANVDDHHQILP--INAFGLQSNGTATASPLLLINSSALADSVSSTTIS 213
            |.|||.|:|...|.......|   .::|  :||    :|||.....|
Mouse   135 GPFAVISLMIGGVAVRLVPDD---IVIPGGVNA----TNGTEARDAL------------------ 174

  Fly   214 PFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTA 278
                           :::||.|:.|..||:...:...|.|.::..|:||||.|||||||.||.|:
Mouse   175 ---------------RVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTS 224

  Fly   279 QLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRF 343
            .||.:.|:...|:.|.|.::|:.:.|::.|...|:.:.|..:.|...::...| ...|..:|...
Mouse   225 MLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKE-FNERFKEKLPA 288

  Fly   344 PLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSI 408
            |:|.|...|:.||.||..|||:..|:|:.||.:|.||..|..|...|...|.||:||||||.:|:
Mouse   289 PIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSV 353

  Fly   409 IMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSA 473
            .:||..|.|.||||:|..||||.|:||.|.:|..|....::||||||::|:.|||.:|:|..:::
Mouse   354 TISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLAS 418

  Fly   474 SLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIID 538
            .::::.::..|..|.|||:.||:.::||.||.||||..:|..|.:..|:|:..|::||:..:.:.
Mouse   419 LMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLG 483

  Fly   539 IDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFA 603
            :|.||:..:.|:||.:..:...|...:||.:|:. .:|:|::.:....::|.::||:.:..:.:|
Mouse   484 LDYGLITAVIIALLTVIYRTQSPSYKVLGQLPDT-DVYIDIDAYEEVKEIPGIKIFQINAPIYYA 547

  Fly   604 TSLFFRRALYEAVGLDKIPL-----------------------------TKVSSSNSNSP-SKGS 638
            .|..:..||....|::...:                             .:|...|:..| .:..
Mouse   548 NSDLYSSALKRKTGVNPALIMGARRKAMRKYAKEVGNANVANATVVKVDAEVDGENATKPEEEDD 612

  Fly   639 KSSYSPVSQNGGKAINGKLEETSGAF-------KVLVLDFSMLGHIDVAGCRTLTDLSKELKVRG 696
            :..:.|:      .|.....|....|       ..::|||:.:..:|..|.:||..:.||....|
Mouse   613 EVKFPPI------VIKTTFPEELQRFLPQGENVHTVILDFTQVNFVDSVGVKTLAGIVKEYGDVG 671

  Fly   697 ARLLLASPVDRVYDTLV-----HSMALSEGPFEIFPTLHDCV 733
            ..:.||....:|.:.|.     .:.||.|   .:|.::||.|
Mouse   672 IYVYLAGCSPQVVNDLTRNNFFENPALKE---LLFHSIHDAV 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	211/692 (30%)
Slc26a5	NP_109652.3	PRK11660	66..709	CDD:481320	212/693 (31%)
		Involved in motor function. /evidence=ECO:0000250|UniProtKB:Q9JKQ2	158..168		4/13 (31%)
		Extended region for STAS domain. /evidence=ECO:0000250|UniProtKB:Q9EPH0	505..718		42/216 (19%)
		STAS_anti-anti-sigma_factors	589..683	CDD:132914	19/99 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	720..744