DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prestin and slc26a1

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_005161263.1	Gene:	slc26a1 / 791185	ZFINID:	ZDB-GENE-070112-2182	Length:	711	Species:	Danio rerio

Alignment Length:	731	Identity:	222/731 - (30%)
Similarity:	391/731 - (53%)	Gaps:	71/731 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSWNFFALFTGVIPILQWLPQYSP 92
            |.:::.|..: |:::..::   |...:.....|.|:|             ||..|:::|||:|..
Zfish    22 KRRVRQKRGV-REIIKTKI---QRNLSCTGPKIKSTL-------------TGFFPVVKWLPKYKV 69

  Fly    93 RRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVAS 157
            :..:.||:::|..:.|:.||..:||.:|||:....|||.:.|..:.|.|:|||:|:|:|.|::.|
Zfish    70 KEYIWGDVMSGLIIGIILIPQAIAYCLLAGLEPIYGLYTSFFSNIIYFFMGTSRHVSVGIFSLMS 134

  Fly   158 MMTAKVVD--TYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNS 220
            :|..:|||  .:....|.::....||||....|                    .|.|:...|...
Zfish   135 LMVGQVVDREVFLAGFDLNEDSTKNAFGFNDTG--------------------ETNITAVNLKIM 179

  Fly   221 TLNAD---PITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKD 282
            :||.:   ....|.:||:|....|:..:||||||||.:|..||.|:::||.|.|:|.:::.|.|.
Zfish   180 SLNMECGKECYAISIATALTFLAGVYQVLMAFLRLGFVSVYLSSPMLDGFATGASCTILSVQAKY 244

  Fly   283 VLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFC----MAVIAFMMICNEILKPRLSKKCRF 343
            :||:.:|||:|...::.|.|::.|.:.:||     ||    .|:...:::..:.::.|..|..:.
Zfish   245 LLGLKIPRHQGYGTVVVTWINIFKNIHKTN-----FCDLITSAICIIVLLAGKEIQDRYKKILKI 304

  Fly   344 PLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSI 408
            |||.||::|...|::|.:.:|...::.:..|.||:|...|.:|.::|:|::|.|:|.:|:::::.
Zfish   305 PLPTELVVVAVATIVSHFADLNGQFSSSISGAIPTGFIPPKMPSIELMPRIAWDAIPLAVISFAF 369

  Fly   409 IMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSA 473
            .:|:...|||||||.||||||:.|:|..|::...|.....:.:|::::::|..|..:|::|:|||
Zfish   370 TVSLSEMFAKKHGYTVRPNQEMIAIGFCNIIPSFFHSFTTSAALAKTMVKDSAGCQTQVSSIVSA 434

  Fly   474 SLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIID 538
            .:|::.|::..|||.:|.:||||.:|||:|:....:.:::.|..:|.|:|...|:.|.....:|.
Zfish   435 LVVLLVLLFFAPFFYALQKCVLACIIIVSLRGALRKFRDVPKQWRQSKIEAIVWLVTMSSTALIS 499

  Fly   539 IDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFA 603
            :::||:||:..|::.:.::...|...|||.: |....|.|:.::.|...||.|:|||:...|.:|
Zfish   500 VELGLVIGVIFSMICVVVQTQNPKVSLLGQI-EQTNDYEDMEEYDNLSPVPNVKIFRFQAPLFYA 563

  Fly   604 TSLFFRRALYEAVGLDK-IPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAINGKLEETSGAFKVL 667
            ...||.::||:|..|:. :.||:.......:.:||.|.:......||...|  .|......|..:
Zfish   564 NKDFFLKSLYKATKLEPFLELTRRRKLEKKARAKGQKMTDGVDQTNGDVGI--CLISKDVGFHTI 626

  Fly   668 VLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLVHSMALSEGPF--------- 723
            :||.|.:..||.....|...:||:.|..|..::||.....|.|      :|.:|.|
Zfish   627 ILDCSCISMIDTTAVSTFKTVSKDYKEVGVNVILACCNTTVID------SLRKGSFFGADDIDMD 685

  Fly   724 -EIFPTLHDCVEYANA 738
             .:|.|:|..|.:||:
Zfish   686 RLLFHTIHSAVCFANS 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	209/668 (31%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	44/158 (28%)
slc26a1	XP_005161263.1	sulP	59..695	CDD:273284	210/669 (31%)
slc26a1	XP_005161263.1	STAS_SulP_like_sulfate_transporter	542..691	CDD:132913	43/156 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574459
Domainoid	1	1.000	59	1.000	Domainoid score	I10623
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1977
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm25589
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860