Protein Alignment Prestin and slc26a6

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_001072916.2
• Gene: slc26a6 / 780378
• XenbaseID: XB-GENE-919879
• Length: 735
• Species: Xenopus tropicalis
• Alignment Length: 708
• Identity: 218/708 - (30%)
• Similarity: 370/708 - (52%)
• Gaps: 101/708 - (14%)

  Fly    75 ALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAY 139
            :|....||||.|:|:|..|..|.|||:||.:|.|:.:|.|:||.:||||....|||.:.||||.|
 Frog    61 SLLLKFIPILGWIPRYPVREWLLGDIVAGLSVGIIQLPQGLAYALLAGVPPVYGLYSSFFPVLLY 125

  Fly   140 MFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALA 204
            ...|||:|||.|||||.|:|...|.::         ::|...:.|..|.|       |||.:|..
 Frog   126 AIFGTSRHISPGTFAVISVMVGSVTES---------LVPSELYTLPGNET-------LINITARD 174

  Fly   205 DSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTT 269
            :.                      ::.||::|...||:..:::..:::|.:.:.|||||:.|:|:
 Frog   175 ND----------------------RVAVASALTFLVGLFQIMLGLVQVGFVVTYLSEPLIRGYTS 217

  Fly   270 AAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNF---GFCMAVIAFMMICNE 331
            |||.||..:|:|.|||:.:.:......:||.::::...:|:||:.:.   |..:.|:..:...|:
 Frog   218 AAAIHVTVSQMKSVLGVQISQRSHPLSLIYAIVNLCAKLPETNIASLLIGGIAITVLFVVKFLND 282

  Fly   332 ILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAV 396
                :.|.|.|.|:|.|||.:|..|.||...||...|.|:.||:||:|:..|::|...:...|..
 Frog   283 ----KYSSKIRMPIPIELITLIVATGISYGANLNQVYGVDIVGEIPTGMKAPMVPNASIFASVVG 343

  Fly   397 DSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQT 461
            ::.|||:|.|:..:|:...||.||||.|..||||.|:|:.|.:|..|.|..:..::|||::|:.|
 Frog   344 NAFAIAVVVYAFTISLAKMFAVKHGYNVDSNQELIALGLSNSIGSFFQCFTIGTAMSRSLVQEST 408

  Fly   462 GGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFT 526
            ||.||:||.||:.::::.::..|..|.:||:.:||.|::|.||.::.|..::....:..|:::..
 Frog   409 GGHSQVASAVSSLVILIIILRAGELFQTLPKAILAAVVVVNLKGIYKQFTDVPMLWRSNKIDLLV 473

  Fly   527 WISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEV 591
            |:.|||..:::::||||.:.:..|||.:..:..||:..:||.: :...||.|:.|.....::..:
 Frog   474 WVVTFLATILLNLDIGLAVSVAFSLLTVIFRTQKPHYSILGKV-DNTDIYRDVAQFDQVTEIQGI 537

  Fly   592 RIFRYSGSLNFATSLFFRRALYEAVG--LDK-IPLTK---------------------------V 626
            :|||.|.:|.||.:..:..::....|  :|| |.|.|                           :
 Frog   538 KIFRSSCTLYFANANLYAESVKRMCGAEVDKLIELKKKAIKKQKQLQEKAEKQRKKENKRKEKEL 602

  Fly   627 SSSNSNSP-SKGSKSSYSPVSQNGGKAINGKLEETSG---------AFKVLVLDFSMLGHIDVAG 681
            .|..|||| :|..:...:|    |.:|:     |.:|         .|..|:||.|..|.:|...
 Frog   603 DSIVSNSPAAKEPEIQIAP----GYEAL-----EDAGLDYFGSEKCTFHSLILDLSTAGFLDTVS 658

  Fly   682 CRTLTDLSKELKVRGARLLL----ASPVDRVYDTLVHSMALSEGPFEIFPTLHDCVEY 735
            .:.|.::.::.:....::.|    ||.::::......|.::::.  .:|.::||.|.|
 Frog   659 IKVLKNIFRDFQEIDVQVYLTGCQASIIEQLDVGNFFSKSITKN--LLFNSVHDAVMY 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	212/695 (31%)
slc26a6	NP_001072916.2	PRK11660	68..711	CDD:481320	213/696 (31%)