Protein Alignment Prestin and slc26a4.3

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_001107135.1
• Gene: slc26a4.3 / 779605
• XenbaseID: XB-GENE-950380
• Length: 778
• Species: Xenopus tropicalis
• Alignment Length: 757
• Identity: 220/757 - (29%)
• Similarity: 356/757 - (47%)
• Gaps: 104/757 - (13%)

  Fly    34 KYSIHRDVLTHEVVIKQTGYAAR-DKSIPSSL-RNC-WRSWNFFALFTGVIPILQWLPQYSPRRD 95
            :|.:||.|..............| .|::...: :|| ..|...:.:.....|:|.|||:|..:..
 Frog    15 QYLVHRSVYNEPTFQDDNERKERVQKTVQDRIKKNCSCTSKKAYFIVKKFFPVLDWLPKYRWKEW 79

  Fly    96 LPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMT 160
            ...|:|:|.:..::....|:|:.:||.|..|.|||.:.||:|.|.|||||||||:|.|.|.|:|.
 Frog    80 FVNDLISGVSTGLVGTLQGLAFALLAAVPVGYGLYSSFFPILTYFFLGTSKHISVGPFPVVSLMV 144

  Fly   161 AKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNAD 225
            ..||         ..|.|...|.:..|.|..        :..:.|:|                |.
 Frog   145 GSVV---------LSIAPDEKFAILGNATGL--------NKTIIDTV----------------AR 176

  Fly   226 PITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPR 290
            ...:|.|:.:|:..:||:.|.:...::|.:...|::|||.|||||||..|..:|.|.||.:....
 Frog   177 DAARIAVSGTLSFLIGIIQLALGIFQIGFIVRYLADPLVGGFTTAAAFQVFVSQFKLVLNVPTQN 241

  Fly   291 HKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEI--LKPRLSKKCRFPLPAELIMVI 353
            :.|...||||:.|:...:..||:.:.   :|.:...::|..:  :..|..:..|.|:|.|:|:.|
 Frog   242 YNGVLSIIYTIRDIFMNIRLTNIADL---IAGLLTFVVCVVVKEINDRYKRIFRVPIPIEVIVTI 303

  Fly   354 GGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAK 418
            ..|.||...||:..||...|..||||...|:.|.:.|..::...:.:|.||.|::.:|:|..:|.
 Frog   304 VATGISYGVNLHAKYNAGIVATIPSGFIPPMTPDVSLFSQIGSSAFSIGIVAYAVAVSVGKVYAT 368

  Fly   419 KHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWI 483
            ||.|||..|||..|.||.|:.||.|||.....:|||:.:|:.|||.:|||.::||.:|::.::.:
 Frog   369 KHNYEVDGNQEFIAFGISNLFGGAFSCFCATTALSRTAVQESTGGRTQIAGIISAGIVLIAIVAL 433

  Fly   484 GPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGIC 548
            |.....|.:.|||.::|..||.||.|..::.:..||.|.:...|:.|.:..:.:.:|.|||.|:.
 Frog   434 GRLLEPLQKSVLAAIVIANLKGMFWQVFDIPRLWKQNKWDSAIWVFTCIASIFLGLDSGLLAGLL 498

  Fly   549 ISLLALYIKGLKPYSCLLGYMPEAPG--IYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRA 611
            ..|..:.::...| ||  |.:...||  ||.::.:::|.::...|:|.|::..:.:.....|:.|
 Frog   499 FGLATILLRVQFP-SC--GALGNVPGTDIYKNVKEYKNLIEPEGVKIIRHTSGMFYGNIDGFKNA 560

  Fly   612 LYEAVGLDKI--------PLTKVSS---------------SNSNSPSKG---SKSSYSPVSQNGG 650
            :...||.|.:        .|.|:..               ||:.:.::|   .:....|..:|.|
 Frog   561 IKSIVGFDPVKVYNKRTKALRKIQKLIKKGQLRSTKNGVISNTGTDNEGFEPDEDVEDPEQENNG 625

  Fly   651 ----KAI------NGKLEETSGAFKV----LVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLL 701
                |.:      |.:|.......||    ::.||..:..|||...|:|..:.||||.......:
 Frog   626 AVQTKEVEIQVDWNSELPVKISVPKVSIHSIIFDFGQIHFIDVVAVRSLKVIFKELKRIDVEPYI 690

  Fly   702 ASPVDRV---------YDTLV-HSMALSEGPFEIFPTLHDCV 733
            |:..|.|         :|.:: |.:        .|.|:||.|
 Frog   691 AACEDGVLQKMGSCLFFDEIIKHDI--------FFLTVHDAV 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	208/702 (30%)
slc26a4.3	NP_001107135.1	PRK11660	66..723	CDD:481320	209/703 (30%)