Protein Alignment Prestin and slc26a3.2

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_001035265.1
• Gene: slc26a3.2 / 563896
• ZFINID: ZDB-GENE-041210-179
• Length: 762
• Species: Danio rerio
• Alignment Length: 753
• Identity: 223/753 - (29%)
• Similarity: 344/753 - (45%)
• Gaps: 125/753 - (16%)

  Fly    35 YSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSWNFFALFTGVIPILQWLPQYSPRRDLPGD 99
            |..|:.:|.| :.:..|..:.|.|:...||                :|::.|:..||.:..|..|
Zfish    29 YRKHKGLLDH-IKLYCTCTSERAKNAALSL----------------LPVIGWMKIYSIKEWLLND 76

  Fly   100 IIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVV 164
            |::|.:..::.:..|:|:.:||.:|...|||.|.|||:.|.|||||:|||:|.|.|.|:|...||
Zfish    77 IVSGVSTGLVAVLQGLAFSLLASISTWYGLYAAFFPVIIYFFLGTSRHISVGAFPVLSLMVGAVV 141

  Fly   165 DTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNADPITK 229
            .         :::|                          |......|:.|:.|.....     :
Zfish   142 T---------KLVP--------------------------DEGPPANITAFEGLTKEEQ-----R 166

  Fly   230 IEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGA 294
            |.|:.||...||:..|.|..|::|.:...||||.::|||||||.|::.:|||.:||::||...|.
Zfish   167 ILVSASLTFLVGLFQLGMGLLQVGFIVMYLSEPYISGFTTAAAVHILVSQLKFILGLTVPGFSGP 231

  Fly   295 FKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGTLIS 359
            ..||||:..|...:..||:.:....:.|:..::...|| ..|...|...|:|.|:||.|....:|
Zfish   232 LSIIYTLESVFTQITSTNIHDLVTSIVVMVAVLAVKEI-NDRFKSKLPVPIPIEVIMTIIACGVS 295

  Fly   360 KWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEV 424
            ..||...::.|:.|||||:....|:.|.|.:....|||:..||||.:::..::...::.||.|.:
Zfish   296 YAFNFRDNHGVDVVGKIPNTFESPIAPDLQVFQMAAVDAFPIAIVGFAVAFAVAKVYSVKHDYII 360

  Fly   425 RPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSS 489
            ..||||.|.|..|:.||.|..:..:.:||||.:|:.|||.:|||.|:||.:|:|.::.||.....
Zfish   361 DGNQELIAFGASNIFGGSFKALAASTALSRSAVQESTGGKTQIAGLLSAIIVLVVILGIGFLLEP 425

  Fly   490 LPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLAL 554
            ||:.||..|:||.||.|.||...:....|:.:.:...|:.|.|..:|:.:||||.:|:.:..|.:
Zfish   426 LPKSVLGAVVIVNLKGMLMQVVTVPYLWKKDRPDCIVWVGTCLAAIILGLDIGLAVGLGLEFLTV 490

  Fly   555 YIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVG-- 617
            ..:...|..|:|..:| ...||.|...:.|..:...|:|||....:.||...|||..|.:|||
Zfish   491 VFRAQFPRCCVLANIP-GTDIYRDRKHYINIFEPEGVKIFRIPSPIFFANIEFFRDKLKDAVGFN 554

  Fly   618 ------------------LDKIPLTKVSSS--------------NSNSPSKGSKSSYS--PVSQN 648
                              |.|..||..|:.              :||:......:.|:  |:..|
Zfish   555 PLRILRKRNKAVKKIKKMLKKGELTLTSNGLQTTCLMPIEESEYDSNADDLDQPTDYTDLPIQIN 619

  Fly   649 GGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLV 713
            ....:...:.........|:||||.:..||::..:.|....||. :|             .|..|
Zfish   620 WNAELPANISVPPVNIHSLILDFSAVSFIDISAIKGLKAAIKEF-IR-------------IDVDV 670

  Fly   714 HSMALSEGPFE----------------IFPTLHDCVEY 735
            :.:....|..|                .|.|:||.|.|
Zfish   671 YIVGCDTGIMEKLKNCKFFDDEIKSSIFFLTIHDAVLY 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	210/700 (30%)
slc26a3.2	NP_001035265.1	PRK11660	59..705	CDD:481320	211/701 (30%)