DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prestin and slc26a4

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_017210528.1	Gene:	slc26a4 / 563818	ZFINID:	ZDB-GENE-060503-544	Length:	779	Species:	Danio rerio

Alignment Length:	700	Identity:	210/700 - (30%)
Similarity:	352/700 - (50%)	Gaps:	77/700 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLG 143
            |::||::|||:|..::.||||:::|.|..::....|:||.:|..|:...|||.|.||:|.|..||
Zfish    58 GLLPIMEWLPKYPVKQWLPGDVVSGVTTGLVCCLQGVAYALLTSVAPVYGLYSAFFPILTYFVLG 122

  Fly   144 TSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVS 208
            ||:|||:|.|.|..:|...||.|.|  .|.|.:..:|              :..:|.:.:.|:
Zfish   123 TSRHISVGPFPVTCLMVGSVVLTLA--PDEHFLRSVN--------------MTDVNETMVEDT-- 169

  Fly   209 STTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAAC 273
                    |:...:.|....::.||.::.:.||::.:.|..:::|.|...||:|||.|||||||.
Zfish   170 --------LMEVDVEAREAQRVMVACTMTVLVGLMQVAMGLMQVGFLVRYLSDPLVGGFTTAAAF 226

  Fly   274 HVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLS 338
            ||..:|:|.:|.:....|.|.|...||:|||...:.|.|:.:....:..|:.:|...|| ..:..
Zfish   227 HVFISQIKTILSVPTHNHNGFFSFAYTLIDVGSNINQANMADLIAGLLTISIVMAVKEI-NTKFQ 290

  Fly   339 KKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAI 403
            .|...|:|.|:|:.:..:.||...:|...|..:.|..:|.|...|..|.::|:..:...|.:.|:
Zfish   291 HKIPVPIPIEVIVTVIASAISHVMDLNSQYGASIVHNLPRGFASPQPPNIELIGSILGSSFSTAV 355

  Fly   404 VTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIA 468
            |.|::.:|:...:|.||.|.|..||||.|.|:.|:.|||||....:.:|||:.:|:.|||.||:|
Zfish   356 VGYAVAVSVAKVYAAKHDYTVNGNQELIAFGVSNIFGGCFSSFVASTALSRTAVQESTGGKSQVA 420

  Fly   469 SLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLC 533
            .|:||.:|::.::.:|||...|.:.||||::|..||.||:|..|:....:|.:.:.|.||::.|.
Zfish   421 GLISAVMVMIVILALGPFLQPLQKSVLAGIVIANLKGMFLQISEVPVLWRQNRTDCFIWIASCLA 485

  Fly   534 VVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSG 598
            .|::.:|:|||.|:...:..:.::...|....||.:|.. .||.::..::...::|.|:||:.:.
Zfish   486 SVVLGLDVGLLAGLVFEMGTVVVRTQFPSCATLGNVPNT-DIYKNMKDYKKVDEIPGVKIFKCNS 549

  Fly   599 SLNFATSLFFRRALYEAVGLDKI--------PLTKVSSSNSNSPSKGSKSSYSPVSQNG------ 649
            .:.||...:|:..|.:.||.|.:        .|.|:.........:.:::...||:..|
Zfish   550 PIYFANIDYFKEKLRDEVGFDAVRVFKKRNKALKKIHKLIKKGKLQVTEAGLVPVASLGVENKGF 614

  Fly   650 ----GKAINGKLEETSGAFKV---------------------LVLDFSMLGHIDVAGCRTLTDLS 689
                |..:..:..:|....|:                     ||:|||.:..:||...::|..:.
Zfish   615 ENEPGHEMEKQASKTDSEVKIQVDWTSELPVSVSVPRVHIHSLVVDFSSVSFLDVVAAKSLKLVV 679

  Fly   690 KELKVRGARLLLASPVDRVYDTLVHSM-ALSEGPFEI-----FPTLHDCV 733
            ||....|..:.:|.    ....||..| |||....|:     |.::||.:
Zfish   680 KEFIRIGVSVYIAG----CDGELVRKMEALSFFDEEVNRDLLFLSVHDAI 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	207/693 (30%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	39/192 (20%)
slc26a4	XP_017210528.1	sulP	61..724	CDD:273284	208/694 (30%)
slc26a4	XP_017210528.1	STAS_SulP_like_sulfate_transporter	533..721	CDD:132913	39/191 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1407
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1977
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm25589
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000