DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and slc26a6l

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001107889.1	Gene:	slc26a6l / 559448	ZFINID:	ZDB-GENE-080220-10	Length:	808	Species:	Danio rerio

Alignment Length:	829	Identity:	236/829 - (28%)
Similarity:	380/829 - (45%)	Gaps:	178/829 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KYSIHRDVLTHEVVIKQTGYAARDK------------SIPSSLRNCWRSWNFFALFTGVIPILQW 86
            :|.:.|:|: :|..:|:........            |:..|:....||      ..|.:|:|.|
Zfish     7 EYHVKREVI-NEQRLKERSQRMNPSQINLPISHRLKTSLSCSVPRIKRS------IVGFLPVLSW 64

  Fly    87 LPQYS------PRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTS 145
            ||:||      |      |:|:|.:|.||::|.||||.:||.:....|||.:::|.|.|...|||
Zfish    65 LPRYSIWDYGMP------DLISGISVGIMHLPQGMAYALLASLPPVFGLYTSLYPSLIYFIFGTS 123

  Fly   146 KHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSST 210
            :|||:|||.:.|:|...|.:..|...|.          |..|||         |.:...|..|.
Zfish   124 RHISVGTFTILSIMIGSVTERLAPDTDF----------LIYNGT---------NVTGEVDIASR- 168

  Fly   211 TISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHV 275
                           .:.:::||.:..:..|::.:::..::.|.:.:.||||||.|:||||:.|.
Zfish   169 ---------------DLYRVQVAAAATVLGGLIQVVLGLVQFGFVGTYLSEPLVRGYTTAASAHA 218

  Fly   276 VTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKK 340
            |.||||.:||:|..|..|...|:||::|:...:|:|:|......:..|..::...| |...|.||
Zfish   219 VVAQLKYILGVSPKRFNGPLSIVYTLVDLFTLLPETHLPTLVASVVSIVVLITAKE-LNNALKKK 282

  Fly   341 CRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVT 405
            ...|:|.||..::..|:||.:..|...|.::.||.|||||..|.:|.:.:..:|.:|:.|:|||.
Zfish   283 MIIPIPVELCTIVVATVISFYTRLNESYKISVVGDIPSGLQPPSVPNVYIFSEVVLDAFAMAIVG 347

  Fly   406 YSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASL 470
            |:|.:|:|.|||.||||:|..||||.|:|:.|.|||.|.|..:..|:|||:||:.|||.:|||.:
Zfish   348 YAISISLGKTFALKHGYKVESNQELVALGLSNTVGGFFQCFSVCSSMSRSLIQESTGGKTQIAGV 412

  Fly   471 VSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVV 535
            ||..:|:||::.:|..|..||:.||:.::.|.||.||.|..::....:..|:::..|:.||:..|
Zfish   413 VSGVIVLVTVLKLGSLFQELPKAVLSAIVFVNLKGMFKQYYDIVTLWRSNKIDLLIWLVTFVSTV 477

  Fly   536 IIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSL 600
            :.::|:||...:..:||.:..:..:|...|||::| ...:|:|:..|:...:||.:.|||.|.::
Zfish   478 LFNLDMGLGASMGFALLTVIFRTQRPSYALLGHLP-GTELYLDMETHKEVREVPGITIFRSSATM 541

  Fly   601 NFATSLFFRRALYEAVGLD--KIPLT-------------KVSSSNSNSPSKGSKSSYSPVSQNGG 650
            .||.:..:..||.:..|||  |: ||             :.:...:...:|..|.::...||...
Zfish   542 YFANAELYLEALKKKSGLDIGKM-LTYKRRQEAKQKRRERRAERRARREAKRQKKAFREASQRSK 605

  Fly   651 KAI-------------NGKL----------EETSGAFKV-------------------------- 666
            .|:             ||.|          .|.:..|.:
Zfish   606 HAVFSVEEEAGQLSDMNGDLHREAEIGWKERENNTVFVIPETARTSDGQHTWMYLKGTDPDTATL 670

  Fly   667 -------------------------------------------LVLDFSMLGHIDVAGCRTLTDL 688
                                                       ::||.|....||....:||.::
Zfish   671 GSVSDLHDADVTTIDSSSEDTLSRDLERVSLGSLGKWTWDIHSIILDLSTANFIDTVAIKTLRNI 735

  Fly   689 SKELKVRGARLLLASPVDRVYDTLVHSMALSEGPFE--IFPTLHDCVEY 735
            ..:.......:.:|...:.|...|......|:...|  :|.|:||.|.|
Zfish   736 FHDFGEIDVHIYMAGCQELVMKQLERGGFFSDVITEACVFATVHDAVLY 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	222/763 (29%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	41/256 (16%)
slc26a6l	NP_001107889.1	Sulfate_transp	77..472	CDD:279284	158/430 (37%)
		HCO3_cotransp	<338..449	CDD:304903	55/110 (50%)
		STAS_SulP_like_sulfate_transporter	<710..777	CDD:132913	13/66 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1407
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1977
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm25589
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900