Protein Alignment Prestin and slc26a6.1

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_001410199.1
• Gene: slc26a6.1 / 558704
• ZFINID: ZDB-GENE-081105-83
• Length: 562
• Species: Danio rerio
• Alignment Length: 629
• Identity: 191/629 - (30%)
• Similarity: 317/629 - (50%)
• Gaps: 93/629 - (14%)

  Fly   115 MAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPI 179
            ||..:|..|....|||.:.:|||.|...|||||||:||||:.|:|.
Zfish     1 MANALLTAVPPVFGLYSSFYPVLVYFVFGTSKHISVGTFAIMSVMV------------------- 46

  Fly   180 NAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVN 244
                    ||.||..||..:||                 ....:||. .::.:|:.|.:..|::.
Zfish    47 --------GTVTADVLLPGSSS-----------------TENQHADS-ARVALASQLTILCGLIQ 85

  Fly   245 LLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGV- 308
            :::..||.|.:...||:|||:|:|||||.||...||..::|||:.||:|...:::....::.|:
Zfish    86 IVLYVLRCGGVCRWLSKPLVSGYTTAAAVHVAINQLPLLMGISIQRHRGLLTVVWMFSSIVSGIR 150

  Fly   309 ---PQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNV 370
               |.|.:|:|     :...:::..:::..|.|  .|||:|.||:::|..||.|...:|...|.:
Zfish   151 RVLPATLVVSF-----ISLVVLVGGKMVNSRWS--TRFPVPWELVLIIFATLSSVQLDLSGQYGI 208

  Fly   371 NPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGI 435
            ..:|.||:||..|.||......::...::|:|:|.|....|:|:.||.||||....||||.|||:
Zfish   209 QIIGPIPTGLSPPSLPSFSFSQELVSTALALAVVGYGFQASLGMMFAHKHGYPFHSNQELLAMGL 273

  Fly   436 GNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVII 500
            .|.:||.|.|.|::.|:|||.:|:.|||.:|::||||:.::::.|:.:||.|..||:.|||.:|:
Zfish   274 CNSIGGVFQCFPVSGSISRSTVQESTGGKTQMSSLVSSLVILLILLKLGPLFQQLPKTVLAVIIL 338

  Fly   501 VALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCL 565
            |.|:.:|.|.||:.|.....::::..|:.|.|..::.::|:||.|.:..|||.:..:..:..|.:
Zfish   339 VNLQGVFAQVKEVPKLWNTDRMDLVVWVVTLLSALVFNLDLGLGIAVVFSLLTIVFRIQRAKSAI 403

  Fly   566 LGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLDKIPLTKVSSSN 630
            ||:: .....|.||:::..|:|||.|.:|.....|.:|.:.....:|.:||
Zfish   404 LGHI-AGTDCYRDLDKYSKAIQVPGVTVFSCFNPLYYANADQTFTSLKQAV-------------- 453

  Fly   631 SNSPSKGSKSS--YSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKELK 693
                :||.|.:  ..|.:|.|          .|.|...::|:.|.:..:|.....:...:.::.:
Zfish   454 ----TKGIKENPEMCPPNQQG----------ASSAQHCVILELSGVTFMDSVAMGSFKSVLQDFE 504

  Fly   694 VRGARLLLASPVDRVYDTL-VHSMA---LSEGPFEIFPTLHDCV 733
            .:......|:..|.:...: .|.:.   ||...|  ||::|..|
Zfish   505 NKQTLFFCAASPDGLLSQMKSHGLVPDLLSLSSF--FPSVHHAV 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	189/625 (30%)
slc26a6.1	NP_001410199.1	PRK11660	1..545	CDD:481320	190/626 (30%)