DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prestin and si:ch211-117c9.2

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_685992.2	Gene:	si:ch211-117c9.2 / 557779	ZFINID:	ZDB-GENE-110408-11	Length:	757	Species:	Danio rerio

Alignment Length:	806	Identity:	243/806 - (30%)
Similarity:	392/806 - (48%)	Gaps:	158/806 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LNNNNTNG---NGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIP---------SSLR 65
            :.||.::|   :.|.         |:.:.|.:|..   :|....|...:.||         .|||
Zfish     1 MRNNTSSGVSKHAGE---------KHCMDRIILDE---LKLEDVAQWQREIPEPSLKEKIRDSLR 53

  Fly    66 NC----WRSWNFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAG 126
             |    |:.|     ....:|:|.|:|.||.|.:..||:::|.:|.||::|.||||.:||.|...
Zfish    54 -CTVGQWKVW-----ILAWMPVLSWIPCYSIRENGLGDLVSGVSVGIMHLPQGMAYALLASVPPV 112

  Fly   127 NGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTAT 191
            .|||.:.:|||.|...|||||||||||||.|:|...|.:..|  .|.|.:         :|||
Zfish   113 FGLYTSFYPVLVYFIFGTSKHISIGTFAVISIMIGSVSERLA--PDGHFL---------TNGT-- 164

  Fly   192 ASPLLLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLS 256
                   |...:.|:                .|..:.:::||.:..|..||..:|:..:|.|.:.
Zfish   165 -------NGLVVVDT----------------EARDLQRLKVAAATTLLCGIFQVLLGVVRFGFVV 206

  Fly   257 SLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMA 321
            :.||||||.|:||.||.|.:|||||.:.|:|..|..|..:::||::::...:|||::......:.
Zfish   207 TYLSEPLVRGYTTGAAAHAITAQLKYMFGVSPRRFTGPLQLLYTLVELCGLLPQTHVPTLVVSLV 271

  Fly   322 VIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLP 386
            .:..::|..|| ....|.:...|:|.||:::..|||||.:..:.....|:.||:||.||..|.:|
Zfish   272 SLTALVIVKEI-NSCYSHRLPLPIPIELMVITAGTLISHYTEMKTINGVDVVGEIPKGLMPPRVP 335

  Fly   387 RLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACS 451
            .:.....||.|:.|:|:|.|:|.:|:|..||.||||:|..||||.|:|:.|.:||.|.|..:..|
Zfish   336 EVCFFSSVAGDAFAVAVVGYAISISLGKIFALKHGYKVDSNQELVALGLSNTIGGFFQCYAVTSS 400

  Fly   452 LSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKF 516
            :|||:||:.|||.:|:|.|:||.:|::|::.:||.|..||..||:.::.|.||.||||.::|...
Zfish   401 MSRSLIQESTGGKTQVAGLISAVIVLITVLKLGPLFEELPTAVLSTIVFVNLKGMFMQCRDLPAL 465

  Fly   517 SKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQ 581
            .:..|:::..|:.||||.|::::|:||...|..:||.:..:..:|...|||.:|:.. :|::...
Zfish   466 WRSNKVDLLVWLVTFLCTVLLNLDLGLAASITFTLLTVIFRTQRPRYSLLGRVPDTE-LYLETES 529

  Fly   582 HRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLD--KIPLTKVSSSNSNSPSKG------- 637
            ::.|..:|.:.|||.|..:.:|.:..:..||.|..|::  ||...|..........||
Zfish   530 YKAAKAIPGITIFRSSTMIYYANAELYHEALLEKSGINIPKILELKKRKEEEEKSKKGQAKDQDK 594

  Fly   638 ---------------------------SKSSYSPVSQNG----------------GK--AINGKL 657
                                       :.:|.:.|:|..                ||  ..:...
Zfish   595 QTGVLRELLNRMLVSLHHHETDHEHIVNDTSIATVTQGNTNCSFQSEQVTEEQEWGKTNTHSSSC 659

  Fly   658 EETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKE-------LKVRGARLLLASPVDRVYDTLVHS 715
            |:|..    ::||||.:..||....:|:.::.::       :.:.|.:..:...::|
Zfish   660 EQTHS----IILDFSSVSFIDTVTLKTIQNICRDYAKVDVTVYISGCQACVVQQLER-------- 712

  Fly   716 MALSEGPF--------EIFPTLHDCV 733
                 |.|        .:||::||.|
Zfish   713 -----GGFFSGSVSKRRLFPSIHDAV 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	223/717 (31%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	36/216 (17%)
si:ch211-117c9.2	XP_685992.2	sulP	68..732	CDD:273284	224/718 (31%)
si:ch211-117c9.2	XP_685992.2	STAS_SulP_like_sulfate_transporter	<660..729	CDD:132913	15/85 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1407
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1977
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm25589
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.000