DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and SLC26A4

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_000432.1	Gene:	SLC26A4 / 5172	HGNCID:	8818	Length:	780	Species:	Homo sapiens

Alignment Length:	773	Identity:	239/773 - (30%)
Similarity:	370/773 - (47%)	Gaps:	106/773 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GNGGSVPSKPKIQPKYSIHRDVLT-------HEVVIKQTGYAARDKSIPSSLR---NCWRSWNFF 74
            |.....|..|:....|.:.|.|.:       ||..:::.      |::..||.   :|.|...|.
Human     5 GGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQER------KTLRESLAKCCSCSRKRAFG 63

  Fly    75 ALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAY 139
            .|.| ::|||:|||:|..:..|..|:|:|.:..::....||||.:||.|..|.|||.|.||:|.|
Human    64 VLKT-LVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTY 127

  Fly   140 MFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALA 204
            ...|||:|||:|.|.|.|:|...||.:.| .|:|..:       ..||||
Human   128 FIFGTSRHISVGPFPVVSLMVGSVVLSMA-PDEHFLV-------SSSNGT--------------- 169

  Fly   205 DSVSSTTISPFQLLNSTL---NADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNG 266
                        :||:|:   .|....::.:|::|.|.|||:.|:...|::|.:...|::|||.|
Human   170 ------------VLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGG 222

  Fly   267 FTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNE 331
            ||||||..|:.:|||.||.:|...:.|...||||::::.:.:..|||.:|...:..|...|...|
Human   223 FTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKE 287

  Fly   332 ILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAV 396
             |..|...|...|:|.|:|:.|..|.||...||..:||...|..||.|...|.||.:.|..::..
Human   288 -LNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLA 351

  Fly   397 DSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQT 461
            .|.:||:|.|:|.:|:|..:|.|:.|.:..|||..|.||.|:..|.|||.....:|||:.:|:.|
Human   352 ASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQEST 416

  Fly   462 GGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFT 526
            ||.:|:|.::||::|::.::.:|.....|.:.|||.|:|..||.||||..::.:..:|.|::...
Human   417 GGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVI 481

  Fly   527 WISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEV 591
            |:.|.:..:|:.:|:|||.|:...||.:.::...|....||.:| :..||.....::|..:...|
Human   482 WVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIP-STDIYKSTKNYKNIEEPQGV 545

  Fly   592 RIFRYSGSLNFATSLFFRRALYEAVGLDKI--------PLTKVSSSNSNSPSKGSKSSY--SPVS 646
            :|.|:|..:.:.....|::.:...||.|.|        .|.|:.....:...:.:|:..  ..||
Human   546 KILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVS 610

  Fly   647 QNGG-----------------KAI------NGKLEETSGAFKV----LVLDFSMLGHIDVAGCRT 684
            .|..                 |.|      |.:|.......||    ||||...:..:||.|.|:
Human   611 TNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRS 675

  Fly   685 LTDLSKELKVRGARLLLASPVDRVYDTLVHSMALSEGPFE-------IFPTLHDCVEY 735
            |..:.||.:.....:..||..|.|.:.|...     |.|:       .|.|:||.:.|
Human   676 LRVIVKEFQRIDVNVYFASLQDYVIEKLEQC-----GFFDDNIRKDTFFLTVHDAILY 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	220/695 (32%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	42/191 (22%)
SLC26A4	NP_000432.1	sulP	70..725	CDD:273284	221/696 (32%)
		STAS_SulP_like_sulfate_transporter	536..722	CDD:132913	41/190 (22%)
		Snf7	<583..654	CDD:304451	11/70 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1619
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2201
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm40651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.100