Protein Alignment Prestin and Esp

DIOPT Version :9

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_001189282.1
• Gene: Esp / 42962
• FlyBaseID: FBgn0013953
• Length: 654
• Species: Drosophila melanogaster
• Alignment Length: 639
• Identity: 151/639 - (23%)
• Similarity: 271/639 - (42%)
• Gaps: 152/639 - (23%)

  Fly    10 TKPLNNNNTNGNGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSW--- 71
            |:|..::|:.|:.||                   .|.::.:.|  .:.|...|:| :|.|||
  Fly    28 TEPNGSSNSVGSQGS-------------------KEFILTEDG--KKVKPTVSTL-DCTRSWLQD 70

  Fly    72 ------NFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLY 130
                  |...|... :|||.|||:|: .:|..||::||.||.:..||..:||..:||:....|||
  Fly    71 CQRRTFNRKTLHKR-LPILGWLPKYN-SQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLY 133

  Fly   131 MAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPL 195
            .:......|:|||:.|.:.:|..|:.:::|.:.                      :.|:...|.|
  Fly   134 ASFVGCFVYIFLGSCKDVPMGPSAIVALLTYQA----------------------AQGSWQKSVL 176

  Fly   196 LLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLS 260
            |.:.|                                        |||.|||....||.|...:|
  Fly   177 LCLLS----------------------------------------GIVELLMGLFGLGFLIDFVS 201

  Fly   261 EPLVNGFTTAAACHVVTAQLKDVLGISVPRHKG-AFKIIYTVIDVIKGVPQTNLVNFGFCMAVIA 324
            .|:.:|||:|.:..::|:|::.||||:.   || .|..|:|  .|...:..|...:....:..|.
  Fly   202 GPVSSGFTSAVSLIILTSQIQSVLGITA---KGNTFVEIWT--QVFHNIEHTRAGDTVLGLTCIV 261

  Fly   325 FMMICNEILKPRL----SKKC-RFPLPAELIMVIGGTLIS---------KWFNLYVDYNVNP--- 372
            .:::...:...|:    .|:| .|......|:.|.||..:         ..:.|:.:.:..|
  Fly   262 ILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGYMLHTEEHGAPFRV 326

  Fly   373 VGKIPSGLPEPVLPRLDLVPKVAVDSIA--------------IAIVTYSIIMSMGLTFAKKHGYE 423
            ||:||.|||...||...|......:.:|              :.|...|::.::.:..|..:|..
  Fly   327 VGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFANGKP 391

  Fly   424 VRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFS 488
            |..:|||.|:|..|:........|...:|||..:.:.:|..:.::::.|..||::.|:::.|:|.
  Fly   392 VDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFY 456

  Fly   489 SLPRCVLAGVIIVALKPMFM-QAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLL 552
            .:||..||.:||.|:  :|| :.|.:|...:..|.::...:.||:..:::.::.|:|||:.::::
  Fly   457 FIPRPTLAAIIISAV--VFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVI 519

  Fly   553 ALYIKGLKP--------------YSCLLGYMPEAPGIYMDLNQHRNAMQVPEVR 592
            .:.....:|              ||.:   .|:...|:..::..||.:....:|
  Fly   520 FILYHAARPKLSTELLTTQSGVEYSMI---TPDRCLIFPSVDYVRNLVNKQSIR 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	134/558 (24%)
		STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	3/11 (27%)
Esp	NP_001189282.1	sulP	86..615	CDD:273284	134/558 (24%)
		HCO3_cotransp	103..520	CDD:304903	116/485 (24%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	5/29 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	P	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
	8	7.770