Protein Alignment Prestin and Prestin

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_061511344.1
• Gene: Prestin / 3291078
• VectorBaseID: AGAMI1_002576
• Length: 676
• Species: Anopheles gambiae
• Alignment Length: 739
• Identity: 349/739 - (47%)
• Similarity: 464/739 - (62%)
• Gaps: 90/739 - (12%)

  Fly    12 PLNNNNTNGNGGSVPSKPKIQPKYS-----IHRDVLTHEVVIKQTGY-----AARDKSIPSSLRN 66
            ||.:..|:          |.:|:||     :.|..|..|...:.:.|     .|.| ||.:|:||
Mosquito     7 PLEDGRTS----------KEKPQYSELSYLVTRQCLQREDFNQLSQYERLKPTALD-SIGASVRN 60

  Fly    67 --CWRSWNFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGL 129
              |      .|...|..|||||||:||.:.||..|:.||.|||::.||.||||||||||:|..||
Mosquito    61 VKC------LASVKGFFPILQWLPKYSIKNDLLSDMTAGLTVAVLQIPQGMAYGILAGVAANVGL 119

  Fly   130 YMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASP 194
            |||.|..|.|...|||:|||:|||||.|:||||:|.||:.|      :|.    |.||||....|
Mosquito   120 YMAFFHSLVYAVFGTSRHISMGTFAVTSLMTAKIVATYSTV------IPT----LASNGTDVPVP 174

  Fly   195 LLLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLL 259
                                 .|:.:.|.| ..|.|:|||:.:...||...:|:..|||.|||||
Mosquito   175 ---------------------DLIPTELGA-VYTPIQVATATSFVAGIFYFIMSAARLGMLSSLL 217

  Fly   260 SEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIA 324
            |||||:|||||||.||:.:||||:||:|:||:||.||:|.:|.|:|...|..||......:.||.
Mosquito   218 SEPLVSGFTTAAAVHVMVSQLKDLLGVSIPRYKGTFKVILSVRDIIDQTPNANLTAVYTSLVVIL 282

  Fly   325 FMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLD 389
            ||:..||..||.||.|||||:||||:.|:|||:.|.:..|..:::|..||.||:|||.|..|.|.
Mosquito   283 FMIFMNEYFKPWLSTKCRFPVPAELMAVVGGTVASYFIGLGPNFDVGLVGSIPTGLPAPEFPPLA 347

  Fly   390 LVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSR 454
            |:..|||||||:.||.|||:||||:.||:|..|||||||||.|:|..|:||..|||||.||||||
Mosquito   348 LIKAVAVDSIAVTIVGYSIVMSMGMIFAQKDNYEVRPNQELVALGFTNIVGSIFSCIPTACSLSR 412

  Fly   455 SVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQ 519
            |:||.||||.:|||::.|:.:::|.|:|:||:|.|||||||||:|:||||.|.:|...:|||.::
Mosquito   413 SLIQHQTGGKTQIAAVFSSMIILVVLLWVGPYFESLPRCVLAGIIVVALKGMLIQVYHIKKFHRE 477

  Fly   520 GKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRN 584
            |.||:|.|..|||.|||||||||||||:.|||::||:||.|.|..|||.:|:. .||:|:..|:.
Mosquito   478 GSLELFVWCVTFLSVVIIDIDIGLLIGVVISLISLYVKGWKTYYSLLGTVPDT-AIYVDIGSHQK 541

  Fly   585 AMQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLDKIPLTKVSSSNSNSPSKGSKSSYSPVSQNG 649
            |.::|.::||:|:||:|||....|::|||:.        |||.          .:::.|.|.:..
Mosquito   542 AEELPHIKIFKYTGSINFANKTNFKKALYKE--------TKVH----------QRANVSLVPRYN 588

  Fly   650 GKAINGKLEETSG--AFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTL 712
            |        ||:|  :.|.:::|.|.:.|:|.|.|:.||::...|:.....||||:|.|.|||.|
Mosquito   589 G--------ETTGLQSTKTVIIDLSSVPHVDTAACKMLTEVKTNLENLSIMLLLATPADCVYDAL 645

  Fly   713 VHSMALSEGPFEIFPTLHDCVEYA 736
            :|:.::.||.|.||||:||.|.:|
Mosquito   646 LHAESIGEGGFNIFPTIHDAVIFA 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	324/650 (50%)
Prestin	XP_061511344.1	None