DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prestin and slc26a5

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_958881.1	Gene:	slc26a5 / 322846	ZFINID:	ZDB-GENE-030131-1566	Length:	739	Species:	Danio rerio

Alignment Length:	757	Identity:	236/757 - (31%)
Similarity:	382/757 - (50%)	Gaps:	85/757 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLR----NCWRSWNFFALFTGVIPIL 84
            :|..:|.....|.:.|.:.:...:..:..:..:....|..||    .|..|....::..|.:|||
Zfish     5 TVSEEPSATLMYHVERPIFSEAYIDSELLHKRKKTPKPYKLRVAEHLCCSSEKVKSVVFGFLPIL 69

  Fly    85 QWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHIS 149
            .|||.|..:..|.|||::|.:..:|.:|.|:||.:||.|....|||.:.:|||.|.|.|||||||
Zfish    70 TWLPSYPLKEYLFGDIVSGISTGVMQLPQGLAYAMLAAVPPVFGLYSSFYPVLLYTFFGTSKHIS 134

  Fly   150 IGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISP 214
            ||||||.|:|...|....|         |.:.|  ..|||         |||.:.:
Zfish   135 IGTFAVISLMIGGVAVREA---------PDSMF--MVNGT---------NSSLVVN--------- 170

  Fly   215 FQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQ 279
                   :.|....::||..:|...|||:..::..||.|.|:..|:||||.|||||||.||..:|
Zfish   171 -------IEARDSRRVEVVVALTTLVGIIQFVLGLLRFGFLAIYLTEPLVRGFTTAAAVHVSVSQ 228

  Fly   280 LKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFP 344
            ||.:||:...|..|...::|::..|::.:..||:|.....:....|:.|..: |..|..||...|
Zfish   229 LKYLLGVKTARFNGPLSVVYSLDAVLRNIADTNIVTLIIGLGCTVFLYIIKQ-LNERFKKKLLIP 292

  Fly   345 LPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSII 409
            :|.|:|:||..|.||....:..:|.|:.|||||:||..|.:|...:.|.:..|::.||:|.:||.
Zfish   293 IPGEIIVVIVSTGISYGMLMSENYGVDVVGKIPTGLLPPKVPDFSVFPNLFADAVPIAVVGFSIT 357

  Fly   410 MSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSAS 474
            :|:..|||.|:||.|..||||.|:|:.|.|...|....:..|:|||::|:.|||.::||.|:::.
Zfish   358 ISLAKTFALKYGYSVDGNQELIALGLCNFVSSFFHTFVVTASMSRSLVQESTGGHTEIAGLLASL 422

  Fly   475 LVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDI 539
            ||::.::.||..|..||..|||.:|:|.|..||.|.:::....::.|:|:..|:.:|...|::.:
Zfish   423 LVLLVVVAIGFVFQPLPTTVLAAIIMVNLLGMFKQTRDIPVLWRKSKIELAIWLVSFFASVLLGL 487

  Fly   540 DIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFAT 604
            |.||.:.:..::|.:..:..:|.:.:||.:|:. |:|.|::::..|.:...::||:.:.|:.||.
Zfish   488 DYGLAVAMAFAILTVIYRTQRPKNVVLGQIPDT-GLYFDVDEYEEAEECSGIKIFQSNSSIYFAN 551

  Fly   605 SLFFRRALYEAVGLD----------KIPLTKVSSSNSNSPSKGS---KSSYSPVSQNGG---KAI 653
            |..:.:||....|:|          ::...|..:..:.:.::||   |::...:....|   :.:
Zfish   552 SELYVKALKAKTGIDPEKLLDAKKLQLKYAKRDTEGTKTVNQGSLLKKNAVVLLDMELGVTHEVL 616

  Fly   654 NG----KLEETSG---------------------AFKVLVLDFSMLGHIDVAGCRTLTDLSKELK 693
            ||    |...|:|                     ....::|||:.:..||..|.:|:..:.||..
Zfish   617 NGPQKPKHVHTNGQMTEKHIESESEDEFFLQRLTPIHSVILDFTPVNFIDSVGAKTIKSVIKEYA 681

  Fly   694 VRGARLLLASPVDRVYDTLVHSMALSE--GPFEIFPTLHDCV 733
            ....:::||.....:...|......||  .|..||||:||.|
Zfish   682 TVDVKVVLAGCSRTLLSELRTLQFFSEPVTPDLIFPTIHDAV 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	223/691 (32%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	40/190 (21%)
slc26a5	NP_958881.1	sulP	67..722	CDD:273284	224/692 (32%)
		LrgB	259..>366	CDD:294396	39/107 (36%)
		STAS_SulP_like_sulfate_transporter	<643..719	CDD:132913	18/75 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1407
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69472
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1977
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm25589
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.900