DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prestin and Slc26a9

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_796217.2	Gene:	Slc26a9 / 320718	MGIID:	2444594	Length:	790	Species:	Mus musculus

Alignment Length:	774	Identity:	205/774 - (26%)
Similarity:	362/774 - (46%)	Gaps:	106/774 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QPKYSIHRDVLTHEVVIKQTGYAARDKSIP--SSLRNCWR--SWNFFALFTGVIPILQWLPQYSP 92
            :|:|.:.|  ..:.:.:....:..:|::.|  ..|||.:|  |..|.|...|::|:|.|||:|..
Mouse     5 RPRYVVDR--AAYSLSLFDDEFEKKDRAYPVGEKLRNTFRCSSAKFKAFVFGLLPVLSWLPKYKI 67

  Fly    93 RRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVAS 157
            :..:..|::.|.:...:.:|.|||:.:||.:.|.||||.:.||:|.|.|||....:..|||||.|
Mouse    68 KDYIIPDLLGGLSGGCIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGIHQMVPGTFAVIS 132

  Fly   158 MMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTL 222
            ::...:.         .|:.|.:.|.:.:|          :.:....|:             :.:
Mouse   133 ILVGNIC---------LQLAPESKFQIFNN----------VTNETYVDT-------------AAM 165

  Fly   223 NADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGIS 287
            .|:   ::.|:.:||....::.:.:.|::.|.::..|||..:.||.|||...::.:.||.:.|::
Mouse   166 EAE---RLHVSATLACLTAVIQMALGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLT 227

  Fly   288 VPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMV 352
            :|.:.|...|::|.||:.|.:|.||:.:..|.:....|:::..| |..|...|..||:|.|:|:|
Mouse   228 IPSYTGPGSIVFTFIDICKNLPHTNIASLIFALVSGVFLVLVKE-LNARYMHKIHFPIPTEMIVV 291

  Fly   353 IGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFA 417
            :..|.||....:...|::..||:|..|.|.||.|.:.....:...:.::|||.|.|.::||.|.|
Mouse   292 VVATAISGSCKMPKKYHMQIVGEIRQGFPTPVAPMVSQWKDMVGTAFSLAIVGYVINLAMGRTLA 356

  Fly   418 KKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMW 482
            .||||:|..|||:.|:|..|..|..|....:.|:||.::..|..||.||:|||..:.:|::|::.
Mouse   357 SKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLV 421

  Fly   483 IGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGI 547
            :|.:...||:.||..:|.|.||....|..:.....::.||:...|:.:||....:.:..|:.:|:
Mouse   422 LGSYLYPLPKAVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCVWVVSFLSSFFLSLPYGVAVGV 486

  Fly   548 CISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRAL 612
            ..|:|.:..:........|..:.:. .||::...:..|.::..|:|..|...|.||.|..||:.:
Mouse   487 AFSILVVIFQTQFRNGSTLAQVMDT-DIYVNPKTYNRAQEIAGVKIVTYCSPLYFANSEIFRQKV 550

  Fly   613 YEAVGLD--KIPLTK------------------------------------------VSSSNSNS 633
            ....|:|  |:.|.|                                          ...:|:.:
Mouse   551 IAKTGMDPQKVLLAKQKYLRKQEKRTAIPTQQRKSLFMKTKTVSLQELQQDFESAPSTDPNNNQA 615

  Fly   634 PSKGSKSSYSPVSQNGGKAINGKL-------EETSG---------AFKVLVLDFSMLGHIDVAGC 682
            |:..:..||...|.:...|...:|       :|.|.         .|..|:||.|.:..:|:.|.
Mouse   616 PAAEAHISYITFSPDASTAAACELPASTRSPQEASDTLASVPPFVTFHTLILDMSGVSFVDLMGI 680

  Fly   683 RTLTDLSKELKVRGARLLLASPVDRVYDTLVHSMALSEGPFE---IFPTLHDCVEYANA 738
            :.|..||...:..|.::.|.:...:||:.:.|.....:|..:   :||::||.|.:|.|
Mouse   681 KALAKLSSTYEKIGVQIFLVNIHAQVYNDISHGGVFEDGCVQRSHVFPSIHDAVLFAQA 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	187/711 (26%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	42/210 (20%)
Slc26a9	NP_796217.2	sulP	57..733	CDD:273284	188/712 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2253
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.890