DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prestin and Slc26a9

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001100642.1	Gene:	Slc26a9 / 304784	RGDID:	1310441	Length:	790	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	205/781 - (26%)
Similarity:	355/781 - (45%)	Gaps:	120/781 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QPKYSIHRDVLTHEVVIKQTGYAARDKSIP--SSLRNCWR--SWNFFALFTGVIPILQWLPQYSP 92
            :|:|.:.|  ..:.:.:....:..:|::.|  ..|||.:|  |....|:..|::|:|.|||:|..
  Rat     5 RPRYVVDR--AAYSLSLFDDEFEKKDRAYPVGEKLRNTFRCSSAKLKAIVFGLLPVLSWLPKYKI 67

  Fly    93 RRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVAS 157
            :..:..|::.|.:...:.:|.|||:.:||.:.|.||||.:.||:|.|.|||....:..|||||.|
  Rat    68 KDYIIPDLLGGLSGGCIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGIHQMVPGTFAVIS 132

  Fly   158 MMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTL 222
            ::...:.         .|:.|                                 .|.||:.|:|.
  Rat   133 ILVGNIC---------LQLAP---------------------------------ESKFQIFNATT 155

  Fly   223 N---ADPIT----KIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQL 280
            |   .|.:.    ::.|:.:||....::.:.:.|::.|.::..|||..:.||.|||...::.:.|
  Rat   156 NETYVDTVAMEAERLHVSATLACLTAVIQMALGFMQFGFVAIYLSESFIRGFMTAAGLQILISVL 220

  Fly   281 KDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPL 345
            |.:.|:::|.:.|...|::|.||:.|.:|.||:.:..|.:....|:::..| |..|...|..||:
  Rat   221 KYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLVFALVSGVFLVLVKE-LNARYMHKIHFPI 284

  Fly   346 PAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIM 410
            |.|:|:|:..|.||....:...|::..||:|..|.|.||.|.:.....:...:.::|||.|.|.:
  Rat   285 PTEMIVVVVATAISGSCKMPKKYHMQIVGEIRHGFPIPVAPMVSQWKDMVGTAFSLAIVGYVINL 349

  Fly   411 SMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASL 475
            :||.|.|.||||:|..|||:.|:|..|..|..|....:.|:||.::..|..||.||:|||..:.:
  Rat   350 AMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLV 414

  Fly   476 VVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDID 540
            |::|::.:|.:...||:.||..:|.|.||....|..:.....::.||:...|:.:||....:.:.
  Rat   415 VMITMLVLGSYLYPLPKAVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCVWVVSFLSSFFLSLP 479

  Fly   541 IGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATS 605
            .|:.:|:..|:|.:..:........|..:.:. .||::...:....::..|:|..|...|.||.|
  Rat   480 YGVAVGVAFSILVVIFQTQFRNGSTLAQVMDT-DIYVNPKTYNRVQEIEGVKIVTYCSPLYFANS 543

  Fly   606 LFFRRALYEAVGLD--KIPLTK------------------------------------------V 626
            ..||:.:....|:|  |:.|.|                                          .
  Rat   544 EIFRQKVIAKTGMDPQKVLLAKQKYLRKQEKRMAVPTQQRKSLFMKTKTVSLQELQQDFESAAST 608

  Fly   627 SSSNSNSPSKGSKSSYSPVSQNGGKAINGKL-------EETSGA---------FKVLVLDFSMLG 675
            ..:|:.:|...:..||...|.:.......:|       .|.|.|         |..|:||.|.:.
  Rat   609 DPNNNQAPVADAHISYITFSPDSSATAASELPTSTQSPREASDALASVPPFVTFHTLILDMSGVS 673

  Fly   676 HIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLVHSMALSEGPFE---IFPTLHDCVEYAN 737
            .:|:.|.:.|..||...:..|.::.|.:...:||:.:.......:|..:   :||::||.|.:|.
  Rat   674 FVDLMGIKALAKLSSTYEKIGVQIFLVNIHAQVYNDISQGGIFEDGCVQRNHVFPSIHDAVLFAQ 738

  Fly   738 A 738
            |
  Rat   739 A 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	188/718 (26%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	40/210 (19%)
Slc26a9	NP_001100642.1	sulP	57..733	CDD:273284	189/719 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335185
Domainoid	1	1.000	62	1.000	Domainoid score	I10054
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2208
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.900