DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and Slc26a6

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001137289.1	Gene:	Slc26a6 / 301010	RGDID:	1310197	Length:	758	Species:	Rattus norvegicus

Alignment Length:	770	Identity:	234/770 - (30%)
Similarity:	385/770 - (50%)	Gaps:	127/770 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 YSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSW------NFFALFTGVIPILQWLPQYSPR 93
            |.:.|.:|..| .::..|:..     |.|..:.||:|      ...:|....:|:|.|||:|..|
  Rat    31 YHVERPLLNQE-QLEDLGHWG-----PVSKTHPWRTWFRCSRARAKSLLIQHVPVLGWLPRYPVR 89

  Fly    94 RDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASM 158
            ..|.||:::|.:||||.:|.|:||.:|||:....|||.:.:||..|...|||:|||:|||||.|:
  Rat    90 EWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPMFGLYSSFYPVFVYFLFGTSRHISVGTFAVMSV 154

  Fly   159 MTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLN 223
            |...|.:                                   |..||...      .|.||:|::
  Rat   155 MVGGVTE-----------------------------------SLTADEAF------VQSLNTTVD 178

  Fly   224 ADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISV 288
            .   .:::||.:|:..||:..:.:..:..|.:.:.||||||..:||||:..|:.:|||.|.||.:
  Rat   179 G---ARVQVAYTLSFLVGLFQVGLGLVHFGFVVTYLSEPLVRSYTTAASVQVLVSQLKYVFGIKL 240

  Fly   289 PRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIA-FMMICNEILKPRLSKKCRFPLPAELIMV 352
            ..|.|...:||||::|...:|:|  |......|::| .:::..::|..:|.::...|:|.||:.:
  Rat   241 NSHSGPLSVIYTVLEVCAQLPKT--VPGTVVTAIVAGVVLVLVKLLNEKLRRRLPLPIPGELLTL 303

  Fly   353 IGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFA 417
            ||.|.||....|...:.|:.||.|.:||..||.|:.:|...:..::.|||:|.::|.:|:|..||
  Rat   304 IGATAISYGVKLNDRFKVDVVGNITTGLIPPVAPKTELFATLVGNAFAIAVVGFAIAISLGKIFA 368

  Fly   418 KKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMW 482
            .:|||.|..||||.|:|:.|::||.|.|.|::||:|||::|:.|||.:|||..||:..:::.::.
  Rat   369 LRHGYRVDSNQELVALGLSNLIGGFFQCFPVSCSMSRSLVQESTGGNTQIAGAVSSLFILLIIVK 433

  Fly   483 IGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGI 547
            :|..|..||:.|||.||||.||.|..|..::....|..::::..|:.||:..:::::||||.:.|
  Rat   434 LGELFRDLPKAVLAAVIIVNLKGMMKQFSDICSLWKANRVDLLIWLVTFVATILLNLDIGLAVSI 498

  Fly   548 CISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRAL 612
            ..|||.:.|:...|:..:||.:|:. .||.|:.::..|.:||.|::||.|.::.||.:..:..:|
  Rat   499 VFSLLLVVIRMQLPHYSVLGQVPDT-DIYRDVAEYSGAKEVPGVKVFRSSATMYFANAELYSDSL 562

  Fly   613 YEAVGLD----------KIPLTKVSSSNSNSPSKGSK----SSYSPVSQN--------------G 649
            .:..|:|          :|...::.....|...|..|    |..|.||.|              |
  Rat   563 KKKCGVDVDRLITQKKKRIKKQEMKIKRMNKAKKSQKQAASSKISSVSVNVNTNFEDIKSNDVEG 627

  Fly   650 GKAINGKLEETSGA-------------------------FKVLVLDFSMLGHIDVAGCRTLTDLS 689
            .:|...:.||....                         |..|:||.|.:..:|....::|.::.
  Rat   628 SEAKVHQGEELEDVVASNQEDAKPPIMTSLKALGLPQPDFHSLILDLSTVSFVDTVCIKSLKNIF 692

  Fly   690 KELKVRGARLLLASPVDRVYDTLVHSMALSEGPF--------EIFPTLHDCVEYA 736
            ::.:.....:.:|:    .|..:|  ..|..|.|        .:|.::||.|.:|
  Rat   693 RDFREIEVEVYIAA----CYSPVV--TQLEAGHFFDESITKQHVFASVHDAVTFA 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	219/710 (31%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	39/208 (19%)
Slc26a6	NP_001137289.1	sulP	78..737	CDD:273284	220/711 (31%)
		HCO3_cotransp	<369..452	CDD:304903	39/82 (48%)
		STAS_SulP_like_sulfate_transporter	<653..734	CDD:132913	14/86 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	279	1.000	Domainoid score	I1618
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2208
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm44790
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870