DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prestin and Slc26a4

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_062087.1	Gene:	Slc26a4 / 29440	RGDID:	3293	Length:	780	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	241/780 - (30%)
Similarity:	377/780 - (48%)	Gaps:	132/780 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPS--SLR-------NCWRSWNFFALFTGVI 81
            |...:....|::.|.|.: |:..:|    .|::.:|.  :||       :|.|...|.|| ..::
  Rat    11 PQLAEYSCSYAVSRPVYS-ELAFQQ----QRERRLPERRTLRDSLARSCSCSRKRAFGAL-KALL 69

  Fly    82 PILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSK 146
            |||.|||:|..:..|..|||:|.:..::....||||.:||.|....|||.|.||:|.|...|||:
  Rat    70 PILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQYGLYSAFFPILTYFVFGTSR 134

  Fly   147 HISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTT 211
            |||:|.|.|.|:|...||.:.|  .|.|.::|      ..||:                ::::||
  Rat   135 HISVGPFPVVSLMVGSVVLSMA--PDDHFLVP------SGNGS----------------TLNTTT 175

  Fly   212 ISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVV 276
            :.     ..|.:|   .::.:|::|.|.|||:.|:...|::|.:...|::|||.|||||||..|:
  Rat   176 LD-----TGTRDA---ARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADPLVGGFTTAAAFQVL 232

  Fly   277 TAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEI--LKPRLSK 339
            .:|||.||.:|...:.|...||||:|::.:.:..||:.:|   :|.:..:::|..:  |..|...
  Rat   233 VSQLKIVLNVSTKNYNGVLSIIYTLIEIFQNIGDTNIADF---IAGLLTIIVCMAVKELNDRFKH 294

  Fly   340 KCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIV 404
            |...|:|.|:|:.|..|.||...||..:||...|..||||...||||.:.|...:...|.:||:|
  Rat   295 KIPVPIPIEVIVTIIATAISYGANLEANYNAGIVKSIPSGFLPPVLPSVGLFSDMLAASFSIAVV 359

  Fly   405 TYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIAS 469
            .|:|.:|:|..:|.||.|.:..|||..|.||.|:..|.|||.....:|||:.:|:.|||.:|:|.
  Rat   360 AYAIAVSVGKVYATKHDYIIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGGKTQVAG 424

  Fly   470 LVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCV 534
            |:||.:|:|.::.:|.....|.:.|||.|:|..||.||||..::.:..||.|.:...|:.|.:..
  Rat   425 LISAVIVMVAIVALGKLLEPLQKSVLAAVVIANLKGMFMQVCDVPRLWKQNKTDAVIWVFTCIMS 489

  Fly   535 VIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGS 599
            :|:.:|:|||.|:...||.:.::...|....||.:| :..||..:..::|..:...|:|.|:|..
  Rat   490 IILGLDLGLLAGLLFGLLTVVLRVQFPSWNGLGSVP-STDIYKSITHYKNLEEPEGVKILRFSSP 553

  Fly   600 LNFATSLFFRRALYEAVGLDKIP----------------------------LTKVSSSNS----- 631
            :.:.....|::.:...||.|.|.                            ::.|.|||:
  Rat   554 IFYGNVDGFKKCVKSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGIISDVGSSNNAFEPD 618

  Fly   632 ---------NSPSKGSK-----SSYSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGC 682
                     :.|:|..:     :|..||..|..|.          ....||||...:..:||.|.
  Rat   619 EDVEEPEELDIPTKEIEIQVDWNSELPVKVNVPKV----------PIHSLVLDCGAVSFLDVVGV 673

  Fly   683 RTLTDLSKELKVRGARLLLASPVD-RVYDTLVHSMALSE----GPFE-------IFPTLHDCVEY 735
            |:|..:.||.:          .:| .||..|:....|.:    |.|:       .|.|:||.:.|
  Rat   674 RSLRMIVKEFQ----------RIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTVHDAILY 728

Fly 736 735
Rat 729 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	223/709 (31%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	41/206 (20%)
Slc26a4	NP_062087.1	sulP	70..725	CDD:273284	224/710 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	279	1.000	Domainoid score	I1618
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2208
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm44790
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.070