DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and SPAC869.05c

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_595014.1	Gene:	SPAC869.05c / 2543130	PomBaseID:	SPAC869.05c	Length:	840	Species:	Schizosaccharomyces pombe

Alignment Length:	718	Identity:	180/718 - (25%)
Similarity:	308/718 - (42%)	Gaps:	150/718 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLR-----NCWRSWNFFALFTGVIPILQWLPQ 89
            :::..|.|..|....|:.           |||...:     |.::  ||......:.||::|||.
pombe    64 RVKAYYEIPEDDELDELA-----------SIPQWFKKNVTSNIFK--NFLHYLKSLFPIIEWLPN 115

  Fly    90 YSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFA 154
            |:|.. |..|:|||.||..:.:|.||:|..:|.:.:..|||.:...|..|.|..|||.:|||..|
pombe   116 YNPYW-LINDLIAGITVGCVVVPQGMSYAKVATLPSEYGLYSSFVGVAIYCFFATSKDVSIGPVA 179

  Fly   155 VASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLN 219
            |.|::||||:   |||             :..:.|.||.
pombe   180 VMSLITAKVI---ANV-------------MAKDETYTAP-------------------------- 202

  Fly   220 STLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVL 284
                       ::||.|||..|.:...:..||||.:...:..|.|.||||.:|.::::.|:..::
pombe   203 -----------QIATCLALLAGAITCGIGLLRLGFIIEFIPVPAVAGFTTGSALNILSGQVPALM 256

  Fly   285 GISVPRHKGAFKIIY-TVIDVIKGVPQTNL-VNFGFCMAVIAFM--MICNEILK--PR------L 337
            |.   ::|...|..| .:|..:|.:|.|.: ..||.....|.|.  .:|..:.|  ||      |
pombe   257 GY---KNKVTAKATYMVIIQSLKHLPDTTVDAAFGLVSLFILFFTKYMCQYLGKRYPRWQQAFFL 318

  Fly   338 SKKCRFPLPAELIMVIGGTLISKWFNLYV-------DYNVNPVGKIPSGLPEPVLPRL------D 389
            :...|     ..::||.||.||     |.       |..::.:..:|.|.....:|.:      |
pombe   319 TNTLR-----SAVVVIVGTAIS-----YAICKHHRSDPPISIIKTVPRGFQHVGVPLITKKLCRD 373

  Fly   390 LVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSR 454
            |..::.|..|.:.:...||..|    |.:.:.|.:.|:|||.|||:.|::|..|:..|...|.||
pombe   374 LASELPVSVIVLLLEHISIAKS----FGRVNDYRIVPDQELIAMGVTNLIGIFFNAYPATGSFSR 434

  Fly   455 SVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQ 519
            |.|:.:.|..:.||.:.:|::|:::|..:...|..:|..:|:.|||.|:..:.:..|:...|.:.
pombe   435 SAIKAKAGVKTPIAGIFTAAVVILSLYCLTDAFYYIPNAILSAVIIHAVTDLILPMKQTILFWRL 499

  Fly   520 GKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEA-----------P 573
            ..||...:..:.:..|...|:.|:.:.:|::...|.::..||:...||.:..|           .
pombe   500 QPLEACIFFISVIVSVFSSIENGIYVSVCLAAALLLLRIAKPHGSFLGKIQAANKYGSDNIANVR 564

  Fly   574 GIY--MDLNQHRNAMQV----PEVRIFRYSGSLNF----ATSLFFRRALYEAV--GLDKIPLTKV 626
            .||  :::.:....:::    |.|.|||...|..:    ..|....|.:.:..  |:|.|.:..:
pombe   565 DIYVPLEMKEENPNLEIQSPPPGVFIFRLQESFTYPNASRVSTMISRRIKDLTRRGIDNIYVKDI 629

  Fly   627 SSSNSNSPSKGSKSSYSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKE 691
            ... .|.|.:..|..            |.::|:.....:.::.|||.:.::|....::|.|:.||
pombe   630 DRP-WNVPRQRKKKE------------NSEIEDLRPLLQAIIFDFSAVNNLDTTAVQSLIDIRKE 681

  Fly   692 LKV 694
            |::
pombe   682 LEI 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	170/661 (26%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	25/123 (20%)
SPAC869.05c	NP_595014.1	SUL1	101..704	CDD:223732	170/668 (25%)
SPAC869.05c	NP_595014.1	STAS_SulP_like_sulfate_transporter	580..717	CDD:132913	25/118 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
TreeFam	1	0.960	-	-
	7	6.700