DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and SPCC320.05

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_587724.1	Gene:	SPCC320.05 / 2538858	PomBaseID:	SPCC320.05	Length:	667	Species:	Schizosaccharomyces pombe

Alignment Length:	610	Identity:	128/610 - (20%)
Similarity:	248/610 - (40%)	Gaps:	176/610 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PSDKE--SPETKPLNNNNTNGNGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKS----- 59
            ||:..  .|:|..::|..:.       |:|             .||:...|:  .||..|
pombe     4 PSENHLLGPKTSFIDNRTST-------SRP-------------LHEIPSYQS--LARRSSTWKRA 46

  Fly    60 -IPSSLRNCWRSWNFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYG----- 118
             ||....:..|..|::      ||:|.|||.|| .|::..|::||.:.|.:::|..:::.
pombe    47 NIPQQKPSLVRRINYY------IPVLHWLPNYS-LRNIIWDVLAGCSTACLSVPIALSFAQTFLG 104

  Fly   119 -----ILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILP 178
                 ||.|.:.|        |:|..:|
pombe   105 VPPIYILTGTAIG--------PILYCLF------------------------------------- 124

  Fly   179 INAFGLQSNGTATASPLLLINSSA-----LADSVSSTTISPFQLLNSTLNADPITKIEVATSLAL 238
                        ||.||:.|...|     :|:::....:|...:...       |.|.|...:|.
pombe   125 ------------TACPLISIGPEAGMCLLIAENIHQRVLSKADVPQE-------TAILVTGLIAF 170

  Fly   239 TVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVID 303
            ..||:||.....|||.|.:|:|..|:.|...:.:..::..|.....|.|..::||:...|..::.
pombe   171 IAGIINLAAGLFRLGFLDALVSPVLLRGCILSISMIIMINQGSVFFGFSGVKYKGSDFPIDKLMF 235

  Fly   304 VIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFP----LPAELIMVIGGTLISKWFNL 364
            :|:.:.:.|:.........|:.::.|.. ||.:||.|  :|    :|..:|:::.|:.:||.|:.
pombe   236 LIRNMSKANIYTTILSCITISLLIGCRN-LKSKLSAK--YPRIVSIPDAVIILLLGSFLSKKFDW 297

  Fly   365 YVDYNVNPVGKIPSGLPEPVLPRLDLVPK-------------------VAVDSI----AIAIVTY 406
            :.:|.:..:|:|.:.:   :||:|.|..|                   ..:|::    ||::.|.
pombe   298 HSNYGIAILGEIKTTI---LLPKLPLPEKNKLHFITQSLQTGVMCSFLAFIDTVIAVKAISLQTN 359

  Fly   407 SIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLV 471
            ::|               |.|:||.::|..|:....|..:|:.....|:.....:|..:|:|::.
pombe   360 NLI---------------RSNRELISLGAANIGSSLFCGLPICGGYLRTKCNIMSGARTQVATIA 409

  Fly   472 SASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAK-ELKKFSKQGKLEMFTW------IS 529
            .:.|:::...:|.|.||::|.|:||.:::.....:|..|. |:.|.::     :..|      .|
pombe   410 CSVLILLATFFIMPVFSTVPTCMLASMVVSLGVSLFADAAVEIFKLAR-----IRVWWELGIIFS 469

  Fly   530 TFLCVVIIDIDIGLLIGICISLLAL 554
            ...|.::..::.|::.|:.|:::.:
pombe   470 IATCTMMFGLETGIIFGLSITVMQI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	110/522 (21%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913
SPCC320.05	NP_587724.1	SUL1	57..667	CDD:223732	113/535 (21%)
SPCC320.05	NP_587724.1	STAS_SulP_like_sulfate_transporter	536..652	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55446
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.870