Protein Alignment Prestin and Slc26a4

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_035997.1
• Gene: Slc26a4 / 23985
• MGIID: 1346029
• Length: 780
• Species: Mus musculus
• Alignment Length: 784
• Identity: 240/784 - (30%)
• Similarity: 377/784 - (48%)
• Gaps: 132/784 - (16%)

  Fly    20 GNGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPS--SLR-------NCWRSWNFFA 75
            |.....|...:....|::.|.|.: |:..:|    .|::.:|.  :||       :|.|. ..|.
Mouse     5 GGRSEPPQLAEYSCSYTVSRPVYS-ELAFQQ----QRERRLPERRTLRDSLARSCSCSRK-RAFG 63

  Fly    76 LFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYM 140
            :...::|||.|||:|..:..|..|||:|.:..::....||||.:||.|....|||.|.||:|.|.
Mouse    64 VVKTLLPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQFGLYSAFFPILTYF 128

  Fly   141 FLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALAD 205
            ..|||:|||:|.|.|.|:|...||.:.|  .|.|.::|      ..||:|
Mouse   129 VFGTSRHISVGPFPVVSLMVGSVVLSMA--PDDHFLVP------SGNGSA--------------- 170

  Fly   206 SVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTA 270
             ::|||:.     ..|.:|   .::.:|::|.|.|||:.|:...|::|.:...|::|||.|||||
Mouse   171 -LNSTTLD-----TGTRDA---ARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADPLVGGFTTA 226

  Fly   271 AACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEI--L 333
            ||..|:.:|||.||.:|...:.|...||||:|::.:.:..||:.:|   :|.:..:::|..:  |
Mouse   227 AAFQVLVSQLKIVLNVSTKNYNGILSIIYTLIEIFQNIGDTNIADF---IAGLLTIIVCMAVKEL 288

  Fly   334 KPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDS 398
            ..|...:...|:|.|:|:.|..|.||...||..:||...|..||||...||||.:.|...:...|
Mouse   289 NDRFKHRIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPSGFLPPVLPSVGLFSDMLAAS 353

  Fly   399 IAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGG 463
            .:||:|.|:|.:|:|..:|.||.|.:..|||..|.||.|:..|.|||.....:|||:.:|:.|||
Mouse   354 FSIAVVAYAIAVSVGKVYATKHDYVIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGG 418

  Fly   464 VSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWI 528
            .:|:|.|:||.:|:|.::.:|.....|.:.|||.|:|..||.||||..::.:..||.|.:...|:
Mouse   419 KTQVAGLISAVIVMVAIVALGRLLEPLQKSVLAAVVIANLKGMFMQVCDVPRLWKQNKTDAVIWV 483

  Fly   529 STFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRI 593
            .|.:..:|:.:|:|||.|:..:||.:.::...|....||.:| :..||..:..::|..:...|:|
Mouse   484 FTCIMSIILGLDLGLLAGLLFALLTVVLRVQFPSWNGLGSVP-STDIYKSITHYKNLEEPEGVKI 547

  Fly   594 FRYSGSLNFATSLFFRRALYEAVGLDKIP----------------------------LTKVSSSN 630
            .|:|..:.:.....|::.:...||.|.|.                            ::.:.|||
Mouse   548 LRFSSPIFYGNVDGFKKCINSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGIISDIGSSN 612

  Fly   631 S--------------NSPSKGSK-----SSYSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGH 676
            :              |.|:|..:     :|..||..|..|.          ....||||...:..
Mouse   613 NAFEPDEDVEEPEELNIPTKEIEIQVDWNSELPVKVNVPKV----------PIHSLVLDCGAVSF 667

  Fly   677 IDVAGCRTLTDLSKELKVRGARLLLASPVD-RVYDTLVHSMALSE----GPFE-------IFPTL 729
            :||.|.|:|..:.||.:          .:| .||..|:....|.:    |.|:       .|.|:
Mouse   668 LDVVGVRSLRMIVKEFQ----------RIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTV 722

  Fly   730 HDCV 733
            ||.:
Mouse   723 HDAI 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	224/709 (32%)
Slc26a4	NP_035997.1	PRK11660	70..725	CDD:481320	225/710 (32%)