DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and Slc26a1

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001297620.1	Gene:	Slc26a1 / 231583	MGIID:	2385894	Length:	720	Species:	Mus musculus

Alignment Length:	683	Identity:	213/683 - (31%)
Similarity:	365/683 - (53%)	Gaps:	53/683 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 ALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAY 139
            ||..|:.|.:.|||||..:..|.||:::|..:.|:.:|..:||.:|||:.....||.:.|..|.|
Mouse    64 ALVQGLFPAIHWLPQYRLKEYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIY 128

  Fly   140 MFLGTSKHISIGTFAVASMMTAKVVD---TYANVDDHHQILPINAFGLQSNGTATASPLLLINSS 201
            ..:|||:|:::|.|::..:|..:|||   ..|..|...     ::.|.::|.:.       :|:|
Mouse   129 FLMGTSRHVNVGIFSLLCLMVGQVVDRELQLAGFDPSQ-----DSLGPKNNDST-------LNNS 181

  Fly   202 ALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNG 266
            |      :|.|...|.......|     |.|||:|.|..|:..:||..||||.:|:.||:||::|
Mouse   182 A------TTLIIGLQDCRRDCYA-----IRVATALTLMAGLYQVLMGILRLGFVSTYLSQPLLDG 235

  Fly   267 FTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNL---VNFGFCMAVIAFMMI 328
            |...|:..::|:|.|.:||:.:|||:|...:::|.:.:::.|.|.|:   |....|:.|    ::
Mouse   236 FAMGASVTILTSQAKHMLGVQIPRHQGLGMVVHTWLSLLQNVGQANICDVVTSALCLGV----LL 296

  Fly   329 CNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPK 393
            ..:.|..|...:.:.|:|.||.:::..|::|.:..|:..::....|.||:|...|.:|...::.:
Mouse   297 AAKELSDRYRHRLKVPIPTELFVIVVATIVSHFGQLHTRFDSRVAGNIPTGFVAPQVPDPKIMWR 361

  Fly   394 VAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQ 458
            ||:|::::|:|..:..:|:...||:.|||.|..||||.|:|..|::...|.|...:.:||:::::
Mouse   362 VALDAMSLALVGSAFSISLAEMFARSHGYSVSANQELLAVGCCNVLPAFFHCFATSAALSKTLVK 426

  Fly   459 DQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLE 523
            ..||..:|::|:|||::|::.|:.:.|.|..|.|||||.:|:|:|:....:.|:|.:..:....:
Mouse   427 IATGCQTQLSSVVSAAVVLLVLLVLAPLFHDLQRCVLACIIVVSLRGALRKVKDLPQLWRLSPAD 491

  Fly   524 MFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQV 588
            ...|::|....|::..:.|||.|:..|||:|..:..:|.:.||..:.::. .|.|..:....:..
Mouse   492 ALVWVATAATCVLVSTEAGLLAGVFFSLLSLAGRTQRPRAALLARIGDST-FYEDAAEFEGLLPP 555

  Fly   589 PEVRIFRYSGSLNFATSLFFRRALYEAVGLDKIPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAI 653
            ||||:||::|.|.:|...||.|:||...|||       :..::....:|.:...|..|...||.:
Mouse   556 PEVRVFRFTGPLYYANKDFFLRSLYRLTGLD-------AGHSATRKDQGPEVGVSNRSLVDGKDL 613

  Fly   654 NGKLEETSG-------AFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDT 711
             |.:...:|       .|..:|:|.:.|..:||||..||.||.::.:.....||||.....|.||
Mouse   614 -GSVSSGAGLVVPLAFGFHTVVIDCAPLLFLDVAGMATLKDLRRDYRALDITLLLACCSPSVRDT 677

  Fly   712 LVHSMALSEGPFE----IFPTLHDCVEYANACR 740
            |.....|.|....    :||::|..||.|.|.|
Mouse   678 LRKGGFLGEEQGAENELLFPSVHSAVEAACARR 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	204/665 (31%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	48/158 (30%)
Slc26a1	NP_001297620.1	sulP	71..702	CDD:273284	205/666 (31%)
Slc26a1	NP_001297620.1	STAS_SulP_like_sulfate_transporter	554..686	CDD:132913	45/139 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831449
Domainoid	1	1.000	61	1.000	Domainoid score	I10421
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm42724
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.810