DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and Slc26a8

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_011244686.1	Gene:	Slc26a8 / 224661	MGIID:	2385046	Length:	1027	Species:	Mus musculus

Alignment Length:	806	Identity:	188/806 - (23%)
Similarity:	342/806 - (42%)	Gaps:	167/806 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 KQTGYAARDKSIPSSLRNCWR-----SWN-FFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVA 107
            :|.|::   :..|..||:|..     ||: |......|.|.|:|:..|..:..|.||::||.:|.
Mouse    68 RQPGWS---RVCPQRLRSCGPPETSCSWHKFLRCMLTVFPFLEWICLYRFKDWLLGDLLAGLSVG 129

  Fly   108 IMNIPHGMAYGILAG--VSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANV 170
            ::.:|.|:...:|..  :...|..|.|....:.|:..|:...:|||.|.:.|.:...|:
Mouse   130 LVQVPQGLILSLLTRQLIPPLNVTYAAFCSSVIYVIFGSCHQMSIGPFFLVSALMINVL------ 188

  Fly   171 DDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATS 235
                :..|.|      ||.       ||..:.:.|..|..|.  :...|.:|:.       ||::
Mouse   189 ----KDRPFN------NGH-------LILGTFVKDDFSVPTF--YLSYNRSLSM-------VAST 227

  Fly   236 LALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYT 300
            ..|| ||:.|.|..|.:|.:::.|.|...:.:..|.|.|::.||:..:|||.|..|.|....||.
Mouse   228 TFLT-GIIQLSMGMLGMGFMATYLPEAATSAYLAAVALHIILAQMTCILGIMVSFHAGPISFIYN 291

  Fly   301 VIDVIKGVPQTNLVN-FGFCMAVIAFMMICNEILKPRLSKKC------RFPL--PAELIMVIGGT 356
            :|:....:|:.|..: ..|..:|:|..:           .||      |:|:  |.||::::|.:
Mouse   292 IINYCIALPKANSTSILLFITSVVALRI-----------NKCIRITFNRYPIEFPMELLLILGFS 345

  Fly   357 LISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHG 421
            |::....:..:.:...:..||.....|..|...::.:|.:.:::::.|:..:::|:|...|..|.
Mouse   346 LLTSKITMATENSKMLMNMIPYSFVFPENPEFGILSRVVLQALSLSFVSSFLLISLGKKIANFHN 410

  Fly   422 YEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPF 486
            |....||:|.|:|:.|::...|.|.....||||:.|||::||..|.||||.|.::::.::.:..|
Mouse   411 YRTNSNQDLIAIGLCNLLSSFFKCCVFTGSLSRTTIQDKSGGRQQFASLVGAGVMLLLMVKMESF 475

  Fly   487 FSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISL 551
            |.:||..||||:|:..:.|.......|....:|.:.|...|:.||...:::.:|:||||.:..:.
Mouse   476 FHNLPNAVLAGIILSNVVPYLEAIYNLPSLWRQDQYECIIWMVTFSSAILLGLDVGLLISLAFTF 540

  Fly   552 LALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAV 616
            ..:.|:..:....:||.:|.. .||.::|.:|..:.:|.|:||:...|:.|......::.:.:.|
Mouse   541 FVITIRSHRTKILVLGQIPNT-NIYRNVNDYREVILIPGVKIFQCCSSITFVNVYHLKQKVLKEV 604

  Fly   617 GLDKIPLTK-------------------------------------------------------- 625
            .:.|:||.:
Mouse   605 NMVKLPLKEEEIYTLFHESETSIAENKLCRCFCDCEELEPEIRVVYTERYENRQEQDSSINLIRC 669

  Fly   626 --------------------VSSSNS----------------NSPSKGS-----KSSYSPVSQNG 649
                                |||::.                |||.:.|     ::|.| ::|:.
Mouse   670 SYLGSGDSSQVTSEEQIPYTVSSTSQRNIVQSYEDTEKAWLPNSPPRNSPLPPPEASES-LAQSR 733

  Fly   650 GKAINGKLEETS--GAFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTL 712
            .::|.....:||  .....::|||||:.::|......|..:..........:|::.....|..:.
Mouse   734 SRSIIMPYSDTSVQNNTHTIILDFSMVHYVDNRALVILRQMCNAFYNANILVLISGCHTSVVKSF 798

  Fly   713 VHSMALSEG--PFEIFPTLHDCVEYA 736
            ..:....||  ..::|.:|||.|.:|
Mouse   799 EKNDFFDEGITKAQLFLSLHDAVLFA 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	174/760 (23%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	36/248 (15%)
Slc26a8	XP_011244686.1	sulP	104..610	CDD:273284	146/550 (27%)
Slc26a8	XP_011244686.1	STAS_SulP_like_sulfate_transporter	<747..806	CDD:132913	9/58 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831450
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850