Protein Alignment Prestin and Slc26a10

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_006513627.1
• Gene: Slc26a10 / 216441
• MGIID: 2143920
• Length: 693
• Species: Mus musculus
• Alignment Length: 724
• Identity: 224/724 - (30%)
• Similarity: 361/724 - (49%)
• Gaps: 99/724 - (13%)

  Fly    33 PKYSIHRDVLTHEVVIKQTGYAARDKSIPSS--------LR----------NCWRSWNFFALFTG 79
            |..|..|:.|||....:..|.|..:..:|:.        ||          ..||      :...
Mouse    30 PLSSRFREPLTHARFQELFGGAEPEPELPAEPCLPCLCRLRRRRASACSGPGAWR------VLLA 88

  Fly    80 VIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGT 144
            .:|.|:|||||..|..|.||.:||.||.::::|.|||:.:|..|....|||.:.||||.|..|||
Mouse    89 RLPPLRWLPQYRWRAWLLGDAVAGVTVGVVHVPQGMAFALLTSVPPVFGLYTSFFPVLIYSLLGT 153

  Fly   145 SKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSS 209
            .:|:|.|||||.|:||..||:         :::|                      ..||.::|.
Mouse   154 GRHLSTGTFAVLSLMTGSVVE---------RVVP----------------------EPLAGNLSG 187

  Fly   210 TTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACH 274
              |...||        ...::..|.::|...|.:.|.|..|:||.||:.||||::...|:.||.|
Mouse   188 --IEREQL--------EARRVGAAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVIKALTSGAALH 242

  Fly   275 VVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSK 339
            |:.:||..:||:|:||..|.|.:..|:..|:..:.|::..........:..::...| |..|...
Mouse   243 VLVSQLPSLLGLSLPRQIGCFSLFKTLAAVLSALSQSSPAEVTISALSLVLLVPVKE-LNVRFRD 306

  Fly   340 KCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIV 404
            :...|:|.|::||:..|::....:|...|||..||.:|.|.|:|:||.||.:|::..||:.|::|
Mouse   307 RLLTPIPGEVVMVLLATVLCFTSSLDTRYNVQVVGPLPGGFPQPLLPTLDELPRILADSLPISLV 371

  Fly   405 TYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIAS 469
            |:::..|:...:|.|:.|.:.|||||.|.|:.|::...|||.|.:.:|:.:.:....||.:|:|.
Mouse   372 TFAVSTSLASIYADKYSYTIEPNQELLAHGVSNLISSLFSCFPNSATLATTSLLVDAGGNTQLAG 436

  Fly   470 LVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCV 534
            |.|.::|:..|:|:.|||..||:.|||.:.|.:::.||.|.:||.:......::...||.|::.|
Mouse   437 LFSCAVVLAALLWLRPFFYYLPKAVLACINISSMRQMFFQMQELPQLWHISHVDFAVWIVTWVAV 501

  Fly   535 VIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGS 599
            |.:::|:||.:|:.:|::.:..: .:...||...:.|...:|..:.:.|..:|||.:.|..|...
Mouse   502 VTLNVDLGLAVGVVVSMMTVVCR-TQRVQCLELGLAEGTELYRPIRESRKLLQVPGLCILSYPAP 565

  Fly   600 LNFATSLFFRRALYEAVGL-DKIPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAINGKLEETSGA 663
            |.|||...|.|.|...:|| ::|....|       |.||::    ||
Mouse   566 LYFATRGQFHRILEWHLGLGERIKPGSV-------PDKGAE----PV------------------ 601

  Fly   664 FKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLVHSMAL-SEGPFEIFP 727
             :|.:||||.:..:|.||.|.:..|::..:..|..||||.....|.:||..:..| |..|.::|.
Mouse   602 -RVAILDFSGITFVDAAGAREVVQLTRRCQDDGIYLLLAQCNALVLETLTRARLLDSVSPEQLFV 665

  Fly   728 TLHDCVEYA 736
            ::.|...:|
Mouse   666 SVQDAAAHA 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	209/650 (32%)
Slc26a10	XP_006513627.1	PRK11660	91..670	CDD:481320	209/651 (32%)