DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and Slc26a10

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_006513627.1	Gene:	Slc26a10 / 216441	MGIID:	2143920	Length:	693	Species:	Mus musculus

Alignment Length:	724	Identity:	224/724 - (30%)
Similarity:	361/724 - (49%)	Gaps:	99/724 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PKYSIHRDVLTHEVVIKQTGYAARDKSIPSS--------LR----------NCWRSWNFFALFTG 79
            |..|..|:.|||....:..|.|..:..:|:.        ||          ..||      :...
Mouse    30 PLSSRFREPLTHARFQELFGGAEPEPELPAEPCLPCLCRLRRRRASACSGPGAWR------VLLA 88

  Fly    80 VIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGT 144
            .:|.|:|||||..|..|.||.:||.||.::::|.|||:.:|..|....|||.:.||||.|..|||
Mouse    89 RLPPLRWLPQYRWRAWLLGDAVAGVTVGVVHVPQGMAFALLTSVPPVFGLYTSFFPVLIYSLLGT 153

  Fly   145 SKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSS 209
            .:|:|.|||||.|:||..||:         :::|                      ..||.::|.
Mouse   154 GRHLSTGTFAVLSLMTGSVVE---------RVVP----------------------EPLAGNLSG 187

  Fly   210 TTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACH 274
              |...||        ...::..|.::|...|.:.|.|..|:||.||:.||||::...|:.||.|
Mouse   188 --IEREQL--------EARRVGAAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVIKALTSGAALH 242

  Fly   275 VVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSK 339
            |:.:||..:||:|:||..|.|.:..|:..|:..:.|::..........:..::...| |..|...
Mouse   243 VLVSQLPSLLGLSLPRQIGCFSLFKTLAAVLSALSQSSPAEVTISALSLVLLVPVKE-LNVRFRD 306

  Fly   340 KCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIV 404
            :...|:|.|::||:..|::....:|...|||..||.:|.|.|:|:||.||.:|::..||:.|::|
Mouse   307 RLLTPIPGEVVMVLLATVLCFTSSLDTRYNVQVVGPLPGGFPQPLLPTLDELPRILADSLPISLV 371

  Fly   405 TYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIAS 469
            |:::..|:...:|.|:.|.:.|||||.|.|:.|::...|||.|.:.:|:.:.:....||.:|:|.
Mouse   372 TFAVSTSLASIYADKYSYTIEPNQELLAHGVSNLISSLFSCFPNSATLATTSLLVDAGGNTQLAG 436

  Fly   470 LVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCV 534
            |.|.::|:..|:|:.|||..||:.|||.:.|.:::.||.|.:||.:......::...||.|::.|
Mouse   437 LFSCAVVLAALLWLRPFFYYLPKAVLACINISSMRQMFFQMQELPQLWHISHVDFAVWIVTWVAV 501

  Fly   535 VIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGS 599
            |.:::|:||.:|:.:|::.:..: .:...||...:.|...:|..:.:.|..:|||.:.|..|...
Mouse   502 VTLNVDLGLAVGVVVSMMTVVCR-TQRVQCLELGLAEGTELYRPIRESRKLLQVPGLCILSYPAP 565

  Fly   600 LNFATSLFFRRALYEAVGL-DKIPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAINGKLEETSGA 663
            |.|||...|.|.|...:|| ::|....|       |.||::    ||
Mouse   566 LYFATRGQFHRILEWHLGLGERIKPGSV-------PDKGAE----PV------------------ 601

  Fly   664 FKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLVHSMAL-SEGPFEIFP 727
             :|.:||||.:..:|.||.|.:..|::..:..|..||||.....|.:||..:..| |..|.::|.
Mouse   602 -RVAILDFSGITFVDAAGAREVVQLTRRCQDDGIYLLLAQCNALVLETLTRARLLDSVSPEQLFV 665

  Fly   728 TLHDCVEYA 736
            ::.|...:|
Mouse   666 SVQDAAAHA 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	209/650 (32%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	44/149 (30%)
Slc26a10	XP_006513627.1	sulP	91..670	CDD:273284	209/651 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980