Protein Alignment Prestin and Slc26a7

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_006537785.1
• Gene: Slc26a7 / 208890
• MGIID: 2384791
• Length: 692
• Species: Mus musculus
• Alignment Length: 668
• Identity: 188/668 - (28%)
• Similarity: 317/668 - (47%)
• Gaps: 100/668 - (14%)

  Fly    81 IPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTS 145
            :|||:|.|||:.:.:|..|.::|..:|:..:..|:::.:|:.|....|||.::||.:.|...|..
Mouse    32 LPILEWAPQYNLKENLLPDTVSGIMLAVQQVAQGLSFAMLSSVHPVFGLYGSLFPAIIYAIFGMG 96

  Fly   146 KHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSST 210
            :|::.||||:.|:::|..|:         :::|      ||:...|...    |||.|.
Mouse    97 RHVATGTFALTSLISANAVE---------RLVP------QSSRNLTTQS----NSSVLG------ 136

  Fly   211 TISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHV 275
             :|.|:|          .:|.||.:::...|::.|:|..|:||:.:.||:||:::..||.||.||
Mouse   137 -LSEFEL----------QRIGVAAAVSFLGGVIQLVMFVLQLGSATFLLTEPVISAMTTGAATHV 190

  Fly   276 VTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKK 340
            ||:|:|.:|||.:|...|.....|....|.:.:....|....|.:..|..:::..| |..:..:|
Mouse   191 VTSQVKYLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLFSLLSIIVLVLVKE-LNEQFKRK 254

  Fly   341 CRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVT 405
            .:..||.:|:::|..:......|:...|.:..||.||:|:|.|..|.::::..|..::..:|:|.
Mouse   255 IKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPNGIPPPRAPPMNILSAVLTEAFGVALVG 319

  Fly   406 YSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASL 470
            |...:::....|||..|.|..|||..|.|:.|::.....|||.|.::.|:.....||..:|:|.|
Mouse   320 YVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACL 384

  Fly   471 VSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVV 535
            :|...|::.:..|||....||.||||.:|:|.||.|.:|.::|||:....|::...||||::..:
Mouse   385 ISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTI 449

  Fly   536 IIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGI------YMDL----NQHRNAMQVP- 589
            ....::|||.|:..::           :.:||..|.|..:      .|:|    ..|.:....|
Mouse   450 CFAANVGLLFGVICTI-----------AIVLGRFPRAKTLSITDMKEMELKVKTEMHDSTENWPP 503

  Fly   590 ----EVRIFRYSGSLNFATS-------------------------LFFRRALYEAVGLDKIPLTK 625
                .|::|  .|||...::                         |.|..|...:..|.||.|
Mouse   504 SKRTNVKVF--PGSLKTGSNIRSLSVTPRRMETSQQIKIISINNPLVFLNAKKFSADLMKIIL-- 564

  Fly   626 VSSSNSNSP----SKGSKSSYSPVSQNGGKAINGKLEETSGAFKV-LVLDFSMLGHIDVAGCRTL 685
             ..|:||.|    ||..:::......||.  .|.:..:...:.|. |||:.|.|...|..|..||
Mouse   565 -KESDSNQPLDDVSKCEQNTLLSSLSNGN--CNEEASQPCSSEKCSLVLNCSGLTFFDYTGVSTL 626

  Fly   686 TDLSKELKVRGARLLLAS 703
            .:|..:.|.|...:.||:
Mouse   627 VELYLDCKSRSVDVFLAN 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	188/667 (28%)
Slc26a7	XP_006537785.1	PRK11660	33..673	CDD:481320	188/667 (28%)