Protein Alignment Prestin and sulp-6

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_491138.3
• Gene: sulp-6 / 189085
• WormBaseID: WBGene00020914
• Length: 856
• Species: Caenorhabditis elegans
• Alignment Length: 702
• Identity: 190/702 - (27%)
• Similarity: 334/702 - (47%)
• Gaps: 73/702 - (10%)

  Fly    68 WRSWNFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMA 132
            |:...:.....|.|||..|||:|:.:.:...|.:.|..|:::::|..:|||:|.||....||...
 Worm   101 WKRKEWIQFARGRIPITMWLPRYTWKSNFLVDFLGGLMVSVLSVPQSLAYGMLVGVPPSYGLITG 165

  Fly   133 VFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLL 197
            :...:.|...|||||.|.|.||:.|:|...||:::.:|.             .:|||..::..||
 Worm   166 IIGPIIYALFGTSKHSSPGAFAIVSLMVGTVVESFGDVG-------------STNGTIDSNVDLL 217

  Fly   198 I---NSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLL 259
            .   |...::|.                     ..|.:|.|:.|.||:..:|...|..|.|:..|
 Worm   218 CCRENKPRVSDG---------------------DAIGIAASVTLLVGLFQILFGLLNAGLLAVWL 261

  Fly   260 SEPLVNGFTTAAACHVVTAQLKDVLGIS-VPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVI 323
            |:.||.|..:.||.||:|:|||.:..|| ||.....|:.:...:...|.:|..:..:....:..:
 Worm   262 SDQLVQGLISGAAVHVLTSQLKSMTRISNVPPTSEPFQNVVFYMCFFKQMPDVDYASIIISVICV 326

  Fly   324 AFMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWF-NLYVDYNVNPVGKIPSGLPEPVLPR 387
            ..::|...::.|.|.||.....|.||::|:..||...:. |...::.:..||::.||:|.||:|.
 Worm   327 VLLLISTLVIDPWLCKKVPVKFPMELVLVVSMTLTVHYTRNTAYEFQIPTVGQVTSGIPAPVIPP 391

  Fly   388 LDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSL 452
            :.....:...:::|||:::.|.:|:....:||..|.|..|||.||:|:.:.....|.|.....||
 Worm   392 MRNAFGMMGSAMSIAIISFVIHISLCKLISKKLQYVVNSNQEWFALGLMHTTSSFFGCFAGGSSL 456

  Fly   453 SRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPF--FSSLPRCVLAGVIIVALKPMFMQAKELKK 515
            .|:::|.:.|..||:::|:: |:|::..:..|..  ...||:.|||.:::||:|.:|:|......
 Worm   457 GRTMMQVKCGTKSQLSTLIT-SIVLIIFVCGGAVGCIQHLPKPVLASIVVVAMKDLFIQIFTCFA 520

  Fly   516 FSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLN 580
            ..|...::...:.:||:.|::::::.|||||:...||.:.::.....|.|||.: .....|..|.
 Worm   521 LRKLSFVDYLIFAATFISVIVLNVNFGLLIGVVFELLTVVLRSQWADSSLLGRI-TGTNHYRRLG 584

  Fly   581 QHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLDKIPLT---KVSSSNSNSPSKGSKSSY 642
            .:..|..:|.::|||:...:.|..|..|.|.:::|.||:  ||.   ::.:.|....::..|...
 Worm   585 LYETANDIPGIKIFRFDSPIYFGNSEMFVRKIHQACGLN--PLIVRGELETENKKKDARKEKEEE 647

  Fly   643 -SPVSQNGGKAINGKLEETSGAFKVL---------------------VLDFSMLGHIDVAGCRTL 685
             :.:.:...|  ..|||.|:...|||                     ::|.|.:.::|:.|...|
 Worm   648 DAEIPKETEK--ETKLEVTTHQAKVLDEKHAEPEPNPADQYERLTHIIIDCSTIIYVDLMGQGAL 710

  Fly   686 TDLSKELKVRGARLLLASPVDRVYDTLVHSMALSEGP-FEIFPTLHDCVEYA 736
            .|:..:.|..|..:|.|:..:.|......|....|.| ..:|.::.|.|:.|
 Worm   711 KDVYNDYKTIGISVLFANTNEHVRQNFETSQFFEEVPRGRMFVSVSDAVDQA 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	184/681 (27%)
sulp-6	NP_491138.3	PRK11660	115..758	CDD:481320	184/682 (27%)