DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and SLC26A3

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_000102.1	Gene:	SLC26A3 / 1811	HGNCID:	3018	Length:	764	Species:	Homo sapiens

Alignment Length:	754	Identity:	206/754 - (27%)
Similarity:	340/754 - (45%)	Gaps:	101/754 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSWNFFA--LFTGVIPILQWLPQYSPRR 94
            :|.||.:.....|    |:||  ...|:....|:.|.......|  :...:.||..|||.|..:.
Human    13 RPVYSTNAFEENH----KKTG--RHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKE 71

  Fly    95 DLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMM 159
            .|..||::|.:..|:.:..|:|:.:|..:....|||.:.||.:.|:|.|||:|||:|.|.:.|||
Human    72 WLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMM 136

  Fly   160 TAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNA 224
            .                      ||..:|..         |.|:.|..::|...|....||:|..
Human   137 V----------------------GLAVSGAV---------SKAVPDRNATTLGLPNNSNNSSLLD 170

  Fly   225 DPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVP 289
            |...::..|.|:.:..||:.|....||:|.:...|||.|::|||||||.||:.:|||.:..::||
Human   171 DERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVP 235

  Fly   290 RHK---GAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAELIM 351
            .|.   ..||::|:|...|:   :||:.:....:.|:..:.|..|| ..|...|...|:|.|.||
Human   236 SHTDPVSIFKVLYSVFSQIE---KTNIADLVTALIVLLVVSIVKEI-NQRFKDKLPVPIPIEFIM 296

  Fly   352 VIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTF 416
            .:....:|...:....:.|..||.:..|...|:.|.::.......|...||:|.:::..|:...:
Human   297 TVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVY 361

  Fly   417 AKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLM 481
            :.|:.|.:..||||.|:|:||:|.|.|.....:.:||||.:|:.|||.:|||.|:.|.:|::.::
Human   362 SLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVL 426

  Fly   482 WIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIG 546
            .||...:.|.:.|||.:.:..||.|.||..|:.:..::.|.:...||.||:..:::.:.:||...
Human   427 AIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAAS 491

  Fly   547 ICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRA 611
            :...||.:..:...|....|..:... .||.:...:.:..:...|:|||....:.||...||||.
Human   492 VAFQLLTIVFRTQFPKCSTLANIGRT-NIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRK 555

  Fly   612 LYEAVG-------------------LDKIPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAINGKL 657
            |.:|||                   |.|..|.:|:...........|.|...:..|..:.::..:
Human   556 LIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPI 620

  Fly   658 EETSGAFKV-------------------LVLDFSMLGHIDVAGCRTLTDLSKE-LKVRGARLLLA 702
            ..|...|.:                   |:||||.:..:||:..|.|..:.:| ::::....::.
Human   621 NTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVG 685

  Fly   703 SPVDRV--------YDTLVHSMALSEGPFEIFPTLHDCV 733
            :..|.:        :|..|.|..       .|.|:||.|
Human   686 TDDDFIEKLNRYEFFDGEVKSSI-------FFLTIHDAV 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	192/698 (28%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	39/194 (20%)
SLC26A3	NP_000102.1	Sulfate_transp	73..475	CDD:279284	137/436 (31%)
		AtpE	376..432	CDD:223709	23/55 (42%)
		STAS_SulP_like_sulfate_transporter	526..712	CDD:132913	38/192 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1619
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2201
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm40651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.970