Protein Alignment Prestin and sulp-4

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_505989.1
• Gene: sulp-4 / 179626
• WormBaseID: WBGene00010788
• Length: 749
• Species: Caenorhabditis elegans
• Alignment Length: 685
• Identity: 193/685 - (28%)
• Similarity: 342/685 - (49%)
• Gaps: 68/685 - (9%)

  Fly    72 NFFAL---FTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAV 133
            :||||   ...:||||:|.|:|..:.||..|||.|.||.:|.:|.|:||.:||...|.||||.::
 Worm    83 SFFALKLFIFDLIPILKWFPEYKWKTDLSLDIIGGITVGVMQVPQGIAYALLAKQPAINGLYTSL 147

  Fly   134 FPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLI 198
            ||.|.||..|||:|.|:|||||.|:||...|:..|...|:.
 Worm   148 FPPLIYMLFGTSRHASLGTFAVVSLMTGLSVEKLAAPTDYD------------------------ 188

  Fly   199 NSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPL 263
                 ..|.:.|.|...:|.:.|         ||:.::.:|:|::..:|..|||..|::.||:.:
 Worm   189 -----PSSFNETDIDLVKLPSPT---------EVSCAITITMGLILFVMGVLRLQFLTTYLSDQV 239

  Fly   264 VNGFTTAAACHVVTAQLKDVLGI-SVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMM 327
            :.|||..::.||:.:|||.:||| .:|||.|.|.:...:.|::..:.:.|.|:.|..:..|..:.
 Worm   240 IAGFTVGSSVHVLVSQLKTLLGIRGLPRHSGPFYLFRHLYDLVMSITRANPVSCGISIVSIIVLH 304

  Fly   328 ICNEILKPRLSKKCR--FPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDL 390
            ...|.:.|.:.:|.:  .|:|.||::||..|:......:..:..|..|.|||.|:|...||...|
 Worm   305 FGKEFINPFIKRKTKSNIPIPWELVIVILSTVFVAVTGVDTEAKVQVVNKIPVGVPNFSLPSFYL 369

  Fly   391 VPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRS 455
            :|:|..|:|:|.:|:.|:.:|:....||::.||:...|||||:...::.......||.:|||||:
 Worm   370 IPQVLPDAISITVVSISVWLSISKMLAKRYNYELDSGQELFALSFASISSSFIPSIPNSCSLSRT 434

  Fly   456 VIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQG 520
            ::....|..:|::...|:.:|...::::|....:||...|:.:|.|||:.||.:..:|....|..
 Worm   435 LVAVGAGCTTQLSIFFSSLIVFSVVIFLGTLLETLPMAALSAIICVALQGMFRKFADLIDLWKVS 499

  Fly   521 KLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNA 585
            |::...|:.:.:..:::|:..||:|.:|.:|....::...|...||..: :....:.|..::...
 Worm   500 KIDFTIWVVSCVSTILLDVSTGLIISVCFALFTTILREQYPKWHLLASV-KGTQDFRDAERYGET 563

  Fly   586 MQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLDKIPLTKVSSSNSNSPSKGSKSSYSPVSQNGG 650
            :....:.|||:...|.|.....|::::.:|       .|:...|:.....:..:.:......:|.
 Worm   564 VYFKGICIFRFDAPLLFHNVECFKKSIEKA-------YTEWQKSHEFYVLREERETILNTKLDGS 621

  Fly   651 -KAINGKLEETSGA----------FKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLA-- 702
             ::|:||:.:|:.:          .:..|:|.|....||:.|...|.::..:::.||..:..|
 Worm   622 DESIDGKMFQTAQSTLNTHSPDILSRHFVIDCSGFTFIDLMGVSALKEIFSDMRKRGILVYFANA 686

  Fly   703 -SPVDRVYDTLVHSMALSEGPFEIFPTLHDCVEYA 736
             :||..:::.......:|:..|  :||:.|....|
 Worm   687 KAPVREMFEKCHFFNFVSKENF--YPTMRDATSIA 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	186/665 (28%)
sulp-4	NP_505989.1	PRK11660	96..715	CDD:481320	186/666 (28%)