DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prestin and Slc26a6

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_036010526.1	Gene:	Slc26a6 / 171429	MGIID:	2159728	Length:	758	Species:	Mus musculus

Alignment Length:	808	Identity:	235/808 - (29%)
Similarity:	398/808 - (49%)	Gaps:	147/808 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDKESPETKPLNNNNTNGNGGSVPSKPKIQPK-YSIHRDVLTHEVVIKQTGYAARDKSIPSSLRN 66
            ||:.:.:|:.|.         |...:.::|.: |.:.|.:|..| .::..|:..     |::..:
Mouse     7 SDQGTHQTQALL---------SAAQEMELQRRDYHVERPLLNQE-QLEDLGHWG-----PAAKTH 56

  Fly    67 CWRSW------NFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSA 125
            .||:|      ...:|....:|:|.|||:|..|..|.||:::|.:||||.:|.|:||.:|||:..
Mouse    57 QWRTWFRCSRARAHSLLLQHVPVLGWLPRYPVREWLLGDLLSGLSVAIMQLPQGLAYALLAGLPP 121

  Fly   126 GNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTA 190
            ..|||.:.:||..|...|||:|||:|||||.|:|...|.:                       :.
Mouse   122 MFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTE-----------------------SL 163

  Fly   191 TASPLLLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTL 255
            ||....:...:|.||.                     .:::||.:|:..||:..:.:..:..|.:
Mouse   164 TADKAFVQGLNATADD---------------------ARVQVAYTLSFLVGLFQVGLGLVHFGFV 207

  Fly   256 SSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCM 320
            .:.||||||..:||||:..|:.:|||.|.||.:..|.|...:||||::|...:|:|  |......
Mouse   208 VTYLSEPLVRSYTTAASVQVLVSQLKYVFGIKLSSHSGPLSVIYTVLEVCAQLPET--VPGTVVT 270

  Fly   321 AVIA-FMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPV 384
            |::| ..::..::|..:|.::...|:|.||:.:||.|.||....|...:.|:.||.|.:||..||
Mouse   271 AIVAGVALVLVKLLNEKLHRRLPLPIPGELLTLIGATGISYGVKLNDRFKVDVVGNITTGLIPPV 335

  Fly   385 LPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMA 449
            .|:.:|...:..::.|||:|.::|.:|:|..||.:|||.|..||||.|:|:.|::||.|.|.|::
Mouse   336 APKTELFATLVGNAFAIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGFFQCFPVS 400

  Fly   450 CSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELK 514
            ||:|||::|:.|||.:|:|..||:..:::.::.:|..|..||:.|||.||||.||.|..|..::.
Mouse   401 CSMSRSLVQESTGGNTQVAGAVSSLFILLIIVKLGELFRDLPKAVLAAVIIVNLKGMMKQFSDIC 465

  Fly   515 KFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDL 579
            ...|..::::..|:.||:..:::::||||.:.|..|||.:.::...|:..:||.:|:. .||.|:
Mouse   466 SLWKANRVDLLIWLVTFVATILLNLDIGLAVSIVFSLLLVVVRMQLPHYSVLGQVPDT-DIYRDV 529

  Fly   580 NQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLD---------------KIPLTKVSSS 629
            .::..|.:||.|::||.|.:|.||.:..:..:|.|..|:|               ::.|.::..:
Mouse   530 AEYSGAKEVPGVKVFRSSATLYFANAELYSDSLKEKCGVDVDRLITQKKKRIKKQEMKLKRMKKA 594

  Fly   630 NSNSPSKGSKSSYSPVSQNGGKAINGKLEETSG-------------------------------- 662
             ..|..:.:.|..|.||.|    :|..||:...
Mouse   595 -KKSQKQDASSKISSVSVN----VNTNLEDVKSNDVEGSEAKVHQGEELQDVVSSNQEDAKAPTM 654

  Fly   663 -----------AFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLVHSM 716
                       .|..|:||.|.|..:|....::|.::.::.:.....:.:|:    .|..:|  .
Mouse   655 TSLKSLGLPQPGFHSLILDLSTLSFVDTVCIKSLKNIFRDFREIEVEVYIAA----CYSPVV--A 713

  Fly   717 ALSEGPF--------EIFPTLHDCVEYA 736
            .|..|.|        .:|.::||.|.:|
Mouse   714 QLEAGHFFDESITKQHVFASVHDAVTFA 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	215/715 (30%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	39/213 (18%)
Slc26a6	XP_036010526.1	sulP	78..737	CDD:273284	216/716 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	279	1.000	Domainoid score	I1678
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2253
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm42724
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970