DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and Slc26a2

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_031911.1	Gene:	Slc26a2 / 13521	MGIID:	892977	Length:	739	Species:	Mus musculus

Alignment Length:	694	Identity:	199/694 - (28%)
Similarity:	357/694 - (51%)	Gaps:	90/694 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SWNFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVF 134
            :::||       |:|:|||:|..::::.||:::|..|.|:.:|..:||.:|||.....|||.:.|
Mouse    89 AFDFF-------PVLRWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPIYGLYTSFF 146

  Fly   135 PVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLIN 199
            ..:.|...|||:|||:|.|.:..:|..:|||.     :.|:..|        :..||:|.:.:.:
Mouse   147 ASIIYFLFGTSRHISVGIFGILCLMIGEVVDR-----ELHKACP--------DTDATSSSIAVFS 198

  Fly   200 SSALADSVSSTTISPFQLLNSTLNA---DPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSE 261
            |..:             ::|.||:.   .....|::.:::....|:..:.|.|.::|.:|..||:
Mouse   199 SGCV-------------VVNHTLDGLCDKSCYAIKIGSTVTFMAGVYQVAMGFFQVGFVSVYLSD 250

  Fly   262 PLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTN---LVNFGFCMAVI 323
            .|::||.|.|:..::|:|.|.:||:|:||..|...:|.|.|.:.:.:..||   |:....|:.|:
Mouse   251 ALLSGFVTGASFTILTSQAKYLLGLSLPRSHGVGSVITTWIHIFRNIRNTNICDLITSLLCLLVL 315

  Fly   324 AFMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRL 388
            ......||..|.:|    :.|:|.|||:|:..||.|.:..|..:||.:..|.||:|...|..|..
Mouse   316 VPSKELNEHFKDKL----KAPIPVELIVVVAATLASHFGKLNGNYNSSIAGHIPTGFMPPKAPDW 376

  Fly   389 DLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLS 453
            .|:|.||||:|||:|:.::|.:|:...|||||||.|:.|||::|:|..|::...|.||..:.:|:
Mouse   377 SLIPNVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCITTSAALA 441

  Fly   454 RSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSK 518
            ::::::.||..:|::::|:|.::::.|:.|.|.|.||.:|||..:.||.|:...::.::|.|..:
Mouse   442 KTLVKESTGCQTQLSAIVTALVLLLVLLVIAPLFYSLQKCVLGVITIVNLRGALLKFRDLPKMWR 506

  Fly   519 QGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHR 583
            ..:::...|..|.|...::..:||||:|:|.|:..:.::..||.:.||| :.|....:..::.::
Mouse   507 LSRMDTVIWFVTMLSSALLSTEIGLLVGVCFSMFCVILRTQKPKNSLLG-LEEESETFESISTYK 570

  Fly   584 NAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLDKIPLTKVSSSNSNSPSKGSKSSYSPVSQN 648
            |......:::||:...|.:.....|:.|||                         |.:.:||...
Mouse   571 NLRSKSGIKVFRFIAPLYYINKECFKSALY-------------------------KKALNPVLVK 610

  Fly   649 GG--KAINGKLEETSGAFK------------------VLVLDFSMLGHIDVAGCRTLTDLSKELK 693
            ..  ||...||:|....|:                  .:|:|.|.:..:|.||..||.::.::.:
Mouse   611 AAWKKAAKRKLKEEMVTFRGDPDEVSMQLSHDPLEVHTIVIDCSAIQFLDTAGIHTLKEVRRDYE 675

  Fly   694 VRGARLLLASPVDRVYDTLVH-SMALSEGPFEIFPTLHDCVEYA 736
            ..|.::|||.....|.|:|.. .....|....:|.:|.:.|.:|
Mouse   676 AVGIQVLLAQCNPSVRDSLARGEYCKKEEETLLFYSLSEAVAFA 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	195/675 (29%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	34/168 (20%)
Slc26a2	NP_031911.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		sulP	94..715	CDD:273284	195/676 (29%)
		STAS	570..707	CDD:294402	33/161 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831445
Domainoid	1	1.000	279	1.000	Domainoid score	I1678
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm42724
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.810